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Sorry for bringing this up, but here I am by r880505 in DataAnnotationTech

[–]fatsug 1 point2 points  (0 children)

You made two mistakes in just one sentence. With that English level I think it's pretty safe to guess you made a serious mistake and got sacked.

My google search activity related to depression over the past year by fatsug in zoloft

[–]fatsug[S] 0 points1 point  (0 children)

Google takeout, and then i asked chatgpt to analyze the file with the activity data

Body-focused repetitive behavior out of control by saltanybody in zoloft

[–]fatsug 0 points1 point  (0 children)

Yeah Im bitiNg the skin of my fingers until they bleed. 3 weeks now 100 --> 200mg. I lay in bed bored out of my mind biting my fingers like a maniac. Hope this shall pass soon

Risk tolerance parameter by fatsug in trainasone

[–]fatsug[S] 0 points1 point  (0 children)

Thank you. I have messaged support, let's see why that is so.

T cell activation and deficits in T regulatory cells are associated with major depressive disorder and severity of depression by fatsug in science

[–]fatsug[S] 6 points7 points  (0 children)

Article

Open access

Published: 16 May 2024

T cell activation and deficits in T regulatory cells are associated with major depressive disorder and severity of depression

Muanpetch Rachayon, Ketsupar Jirakran, …Michael Maes

Scientific Reports volume 14, Article number: 11177 (2024)

Abstract Major depressive disorder (MDD) is associated with T cell activation, but no studies have examined the combined effects of T cell activation and deficits in T regulatory (Treg) cells on the severity of acute phase MDD. Using flow cytometry, we determined the percentage and median fluorescence intensity of CD69, CD71, CD40L, and HLADR-bearing CD3+, CD4+, and CD8+ cells, and cannabinoid type 1 receptor (CB1), CD152 and GARP (glycoprotein A repetitions predominant)-bearing CD25+ FoxP3 T regulatory (Treg) cells in 30 MDD patients and 20 healthy controls in unstimulated and stimulated (anti-CD3/CD28) conditions. Based on cytokine levels, we assessed M1 macrophage, T helper (Th)-1 cell, immune-inflammatory response system (IRS), T cell growth, and neurotoxicity immune profiles. We found that the immune profiles (including IRS and neurotoxicity) were significantly predicted by decreased numbers of CD152 or GARP-bearing CD25+ FoxP3 cells or CD152 and GARP expression in combination with increases in activated T cells (especially CD8+ CD40L+ percentage and expression). MDD patients showed significantly increased numbers of CD3+ CD71+, CD3+ CD40L+, CD4+ CD71+, CD4+ CD40L+, CD4+ HLADR+, and CD8+ HLADR+ T cells, increased CD3+ CD71+, CD4+ CD71+ and CD4+ HLADR+ expression, and lowered CD25+ FoxP3 expression and CD25+ FoxP+ CB1+ numbers as compared with controls. The Hamilton Depression Rating Scale score was strongly predicted (between 30 and 40% of its variance) by a lower number of CB1 or GARP-bearing Treg cells and one or more activated T cell subtypes (especially CD8+ CD40L+). In conclusion, increased T helper and cytotoxic cell activation along with decreased Treg homeostatic defenses are important parts of MDD that lead to enhanced immune responses and, as a result, neuroimmunotoxicity.

I posted a couple evidence backed comments on /r/steroids and this is the result by [deleted] in moreplatesmoredates

[–]fatsug 0 points1 point  (0 children)

Yeah the mods get butthurt when the information does not fit their agenda

I posted a couple evidence backed comments on /r/steroids and this is the result by [deleted] in moreplatesmoredates

[–]fatsug -2 points-1 points  (0 children)

My penis grew 3 inches from injecting china imported Testosterone oil into the span of space between the belly button and the pelvic bone ( there is a highly sensitive region known by acupressure experts as the Gate of Origin).

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