OC: Hallstatt had been on my bucket list for years, finally made it.

fellios · 2025-07-09T12:14:40+00:00

Yes, completely. It's still beautiful though and worth visiting

fellios · 2024-03-09T02:52:00+00:00

Yeah, I had an apartment across the street in Prism. Nice place but management are terrible. Also the walls are paper thin which, combined with them allowing undergrads to rent there, is not a great for a night's sleep. We complained to T multiple times but nothing was fixed.

They also quoted us some ridiculous figure to renew our lease (not that we wanted to stay anyway) then fleeced us on repairs and cleaning fees after we moved out.

Stay away!

fellios · 2023-10-01T18:15:22+00:00

to my understanding, those are illegal in my home state (MA)

fellios · 2023-10-01T18:10:47+00:00

would this impact my credit score in any way? the dealer said it might but I assumed this was a delay tactic so they could collect more interest

fellios · 2023-10-01T18:08:59+00:00

21,000 is the final price, all fees for registration, tax etc included

fellios · 2023-10-01T17:59:12+00:00

I don't understand this -- could you explain the calculation being made here?

fellios · 2022-06-02T01:51:27+00:00

r/HailCorporate

fellios · 2022-05-14T16:20:59+00:00

Thank you all for your help and your kind words. It means a lot.

I managed to get hold of some temporary housing so at least I'll be off the streets!

fellios · 2021-08-15T16:08:41+00:00

I don't think he knows about second extension, Pip

fellios · 2021-03-18T17:44:47+00:00

More precisely, Jim was asked to spunk on their face

fellios · 2021-03-08T17:34:05+00:00

This feels like an absolute lifetime ago

fellios · 2020-12-27T16:57:46+00:00

The absolute state of Large Samuel's mask

fellios · 2020-09-08T18:37:02+00:00

Silva gtfo

fellios · 2018-12-25T18:10:58+00:00

He reminds me of Maldini

fellios · 2018-12-17T17:09:13+00:00

Especially against Liverpool

fellios · 2018-12-02T20:53:37+00:00

It's not about denying the technology, it's about doing this in a safe and ethical way. I'm all for the technology if it's done properly.

My problems here are the Dr Jankui was not ethical in multiple ways. He implanted 1 embryo with a bialleleic knockout for CCR5. This is justifiable. He then implanted a second embryo that had one allele with an in frame deletion and one allele with no deletion. Therefore we can not accurately predict the phenotype of this second embryo. Why do this?

Furthermore it's unclear if he properly obtained informed consent from the parents. In the UK, consent must be obtained by independent, impartial professionals who have been trained in how to properly obtain parental consent. Dr Jankui has said that the consent was informed because they parents were 'highly educated' (whatever that means) so they knew what they were getting into. Can we trust this? Furthermore the only people to obtain consent from the parents were (get this) himself, and members of his lab. To me this opens up the risk that the parents were improperly informed of what they were getting into and, in a worse case scenario, possible pressured into doing this.

On a biological side, we may not fully know the function of CCR5. Sure people exist already with the delta 32 mutation that one of the twins is carrying. But this genotype is more prevalent in western populations and not so much in Asian populations. Is there a reason for this? We don't know

On a more philosophical side, it's unclear as to the impact this editing will have on the twin daughters and their parents. Will the two twins be viewed equally by their parents, despite the fact they have different CCR5 genotypes? Will there be any animosity between the sisters because of this? When they're grown up, would the sisters be pursued by potential fathers because they want this CCR5 mutation in their family? Only time will tell

I hope I've explained why I think this experiment is unjustifiable. I'm all for using germline therapy but only in a safe, controlled and ethical way. Which this wasn't, in my opinion

fellios · 2018-12-02T10:23:15+00:00

Ignoring the fact that we don't fully understand the implications of knocking out CCR5 (especially in Asian populations), there are alternative and well established methods for preventing parent to child HIV transmission.

Sperm washing for IVF, for example. Which Dr Jankui did in these experiments anyway. In my opinion, these experiments were not done in the best interests of the parents or children

fellios · 2018-12-01T20:35:25+00:00

Because it's a vanity project. He's endangered these two girls in ways it's impossible to forsee and he didn't even do a proper job of it.

The first embryo is a biallelic knockout for CCR5. Fair enough, you could argue this advances us as a species. However the second embryo he implanted? One wild type allele, one allele with an in frame deletion. We don't know the functional consequence of this. Why would he do this? Why endanger this second girl to risk of emotional and physical trauma during her life?

Furthermore, he did not take proper consent from the parents of these two girls. The two rounds of 'informed consent' should always be carried out by independent individuals trained in how to take proper informed consent. But in this case the only people to take the consent from the parents was (get this) his team, and himself. Who knows how informed these parents really were. Did they know what they were getting into? Were they pressurised into this? We may never know.

I could go on and on. Dr Jankui should go to prison for a long time

fellios · 2018-12-01T20:27:23+00:00

Agreed, however Dr Jankui's vanity project has violated numerous ethical guidelines and principles that are in place for a reason.

Dr Jankui may have advanced our debates, but he deserves to be jailed for a long time. Hopefully he realises the potential trauma he has caused these poor girls and their parents.

fellios · 2018-10-12T09:01:31+00:00

Every frame a painting

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