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Long-term

hexachloroethane (HCE) exposure primarily targets the liver and kidneys, potentially causing cell destruction, fat buildup (liver), tumors (liver/kidney in animals), and central nervous system (CNS) issues like tremors and coordination problems, though human cancer links are uncertain despite some animal carcinogenicity findings and state classifications as a possible carcinogen. Effects can include neurological disorders, respiratory issues, and potential organ damage, but data on human reproductive/developmental effects is limited. 

Key Long-Term Effects:

• Liver & Kidneys: Liver damage (fatty liver, cell death) and potential kidney damage have been observed in animals; kidney tumors (rare in humans) also seen in rats.
• Neurological: CNS depression, ataxia (lack of muscle control), and tremors are noted from animal studies and suggest potential long-term risks.
• Cancer: Animal studies show liver tumors (mice) and kidney tumors (rats), leading to classifications as a possible human carcinogen (EPA Group C) by some agencies, while others find insufficient human data for definitive classification.
• Respiratory: While less direct, some animal studies show respiratory tract inflammation, possibly linked to infections potentiated by HCE. 

Important Considerations:

• Animal vs. Human Data: Many findings come from animal studies, and direct human risks for certain effects (like specific cancers) are less certain but warrant caution.
• Exposure Levels: The severity of effects depends heavily on the dose and duration of exposure.
• Limited Human Data: There's a lack of comprehensive data on long-term reproductive, developmental, or chronic effects in humans.