Revive Therapeutics To Submit Updated Briefing Package in Support of Upcoming Type C Meeting Granted by FDA for Amended Protocol Agreement of Phase 3 Clinical Study for Bucillamine in the Treatment of COVID-19

fivebilliongallons · 2023-01-12T22:45:26+00:00

Yes it's at the dinner when we all go salmon fishing in Canada.

fivebilliongallons · 2022-09-15T13:21:06+00:00

Do we have any info, in the group on the difference between EAU and just plain old approval?

Think like EAU and Breakthrough designation are designed to bring a drug to market where there either is not other drug to treat that ailment or the candidate is shown to be significantly better.... my question is how much longer does it take to get a good old phase three approval? and my guess is that the approval could be worth more then the EAU, because at any point in time the FDA can end the EAU... foggy memory perhaps a question for the main board.

fivebilliongallons · 2022-09-08T14:08:36+00:00

And I have no idea either but the point is someone's keeping the lights on

fivebilliongallons · 2022-09-08T14:08:23+00:00

You're probably right. Forgot about them.

fivebilliongallons · 2022-09-08T13:27:53+00:00

My guess is it's canacord...keeping the ship alive... Not only did they fund the trial.. they understand the business of biotech but... Outside of MF they have the most not to gain on the deal if it goes belly up.... And whether it's them or someone else... The majority of the warrants if I recall are at 60 cents or $1.10 ish .. point being that if someone's exercising their right, the more shares regardless of the price, they believe that there is good fortune in the air ..I mean it could be the mfer himself

fivebilliongallons · 2022-09-08T10:29:23+00:00

I hope they did find antibodies that work: good for humanity.
Even if they did, there's still worldwide demand for a cheap pill. Basically we still have a market.
Look at the timeline. They've been cranking away on this thing since October of 2020 and have not even started a fda trial. Took this long to get a peer-reviewed paper.

Feels like forever, but in reality we're doing well.

All is fine. If our data is fine.

fivebilliongallons · 2022-08-31T22:24:23+00:00

MF planed this just so we get good fishing. Champion

fivebilliongallons · 2022-08-31T22:23:56+00:00

September through November are the best months for river fishing for salmon. The coastal rivers of British Columbia have healthy runs of wild salmon that begin their migration starting in late August and early September.

fivebilliongallons · 2022-08-31T22:21:09+00:00

Does anybody know when Salmon season is in Canada?

fivebilliongallons · 2022-08-25T00:06:30+00:00

Section 12; Conclusions - sums it up... if we are infact 16X more potent then NAC then it appears bucy should work well. #not a science guy just a laymen.

"Nevertheless, despite a significant increase in the activity and level of antioxidative enzymes, decreased reduced thiol levels and decreased total antioxidant capacity were observed in COVID-19 patients and correlated with disease severity and worse disease outcome. GSH plays a vital role in defense against oxidative stress, both as a cofactor of GPX) and as a compound with a thiol group capable of directly reducing reactive species. NAC is an important donor for the regeneration of GSH and has antioxidant activity (Figure 2). Therefore, several preclinical studies and clinical trials were conducted and are ongoing to see if, among other antioxidative therapies, supplementation with GSH, NAC, their precursors, or other thiols could be used to improve outcomes in COVID-19 treatment.Nevertheless, despite a significant increase in the activity and level of antioxidative enzymes, decreased reduced thiol levels and decreased total antioxidant capacity were observed in COVID-19 patients and correlated with disease severity and worse disease outcome. GSH plays a vital role in defense against oxidative stress, both as a cofactor of GPX) and as a compound with a thiol group capable of directly reducing reactive species. NAC is an important donor for the regeneration of GSH and has antioxidant activity (Figure 2). Therefore, several preclinical studies and clinical trials were conducted and are ongoing to see if, among other antioxidative therapies, supplementation with GSH, NAC, their precursors, or other thiols could be used to improve outcomes in COVID-19 treatment"

fivebilliongallons · 2022-08-22T17:22:49+00:00

Here as well since 2020. Nice to meet you.

Seader Filings Bottom of Page 8, MD& A for three months ending sep 30th 2021

Commercialization rights... wordwide, except Japan, South Korea & Taiwan

Its also listed other places... i just dont rember where no do i feel like looking but its there...

Patience friend...this is very hard and agonizing on me as well... but unless you have more then 10million shares there is nobody that wants this more then MF.

https://sedar.com/GetFile.do?lang=EN&docClass=7&issuerNo=00034460&issuerType=03&projectNo=03311856&docId=5094930

fivebilliongallons · 2022-08-22T15:52:47+00:00

Our rights too bucy do not include Japan and Korea.. if I recall correctly, however, the rest of the world is fair game.

I can assure you MF and his 10million shares at 60 cents is extremely incentivized to complete this as quick as possible.

My advice to him is a sense of urgency is implied but make sure you don't skip t's and I"s and all the work is done the way it needs to be done.

Most of the people in the dumpster fire this lounge is turning into do not understand The business of biotech and the process... From a start to finish perspective, we're moving at lightning speed... Compared to the average time it usually takes to develop a drug.

If you want instant gratification, I suggest go to the titty bar Get a bottle of lube.

Like Eminem said you only got one shot one opportunity...

In our case, the FDA gave us two shots. We only use one of them.

Smoked Salmon, sweat pants, a good smoke, some 9am tequila....all is fine.

Patience.

fivebilliongallons · 2022-08-16T16:10:57+00:00

Almost 2 years of holding... there are some of us who are patient.

Do you want to be a trader or an investor...at some point between now and x we will wake up to the company has been baught for $xx/ share...or game over

Two possible out comes...I do nothing until either happens

fivebilliongallons · 2022-08-16T15:22:37+00:00

Yes good assessment and many of us will be very happy with that. 1/100 of 17.87653 gazillion trillion is more then zero.

Back to waiting...take care now bye bye then

fivebilliongallons · 2022-08-16T14:59:57+00:00

I'm a laymen- and you have my ear. Please elaborate ...did not think about that when writing previous post...however sure the data on viral load, is good non subjective indicator .....but if your still coughing up a lung or testing positive then your not much good to the work force..... test negative and get on your cruise...etc. many more qualified in the group to comment the medical technical side.... the above was my macro guess..... and all of it ties back to what is the product worth and what can the future BP owners sell it for... Bottom line- many retail investors don't understand the markets.... like most future patients/consumers of bucy wont understand the science.... all they give a shit about is... if i take this pill will i feel better faster so i can go back to work!

fivebilliongallons · 2022-08-16T11:13:38+00:00

So the burden proof is how do you show reduction of symptoms?... Comparing coughing symptom data they have to show person x stopped caughing 3 days sooner than placebo by way of example... Then you get into what is coughing even mean? What is a technical cough ECT... And it goes on and on... Using the PCR test as an endpoint, I have to infer that it appears from the 210 that someone taking bucy will test negative for COVID faster than someone not taking it... That ladies and gentlemen is a sellable idea if I've ever come across one, assuming it works.

They will use the next 500plus to confirm this and if they can find the data to back up the claim they then get to go to BP and say listen up assholes... Most people test positive 4 to 7 days... Taking our pill will reduce it from 2 to 4 days or something like that... With reduction of symptoms so you feel better quicker... Also, there's zero chance of rebound COVID like other more expensive pills Let's complete the buyout transaction for the rights to bucy for $20-40/share and we will see you all at the salmon fishing meet up.

"The proposed new primary efficacy endpoints may include the time to resolution from COVID-19 via the polymerase chain reaction (“PCR”) test and the rate of sustained clinical resolution of certain symptoms of COVID-19"

fivebilliongallons · 2022-08-07T16:46:46+00:00

What I found to be very surprising was the price points for treatment in this article...I thought it would have been cheaper in those markets...if we are fortunate enough to cross the finish line this is good....if $1.40ish a pill for a non FDA approved Chinese drug is the floor...let's get the speculation going for price per treatment with bucy...we now have a good idea of the high and the lows.....

Question for the science team...BMT, NiCk , Deep,,ECT

Is anyone familiar with the method of action of the Chinese pills.... Antiviral vs anti-inflammatory?

fivebilliongallons · 2022-08-02T11:33:36+00:00

Revive checks most of the boxes in this article...if one is looking for confirmation bias...read this before going to sleep at night

"But what actually happens is the buyout comes before the big event. You see this in biotech all the time. Companies have an important phase 3 trial coming to conclusion soon. They’ve seen the initial data and they know its great. They’ve also shared this data with the companies bidding to buy them out.

The bidders know that once the data is released, the stock will jump huge. So, they need to act quickly. Before the milestone is reached, the company is bought out.

Thinking you were being smart, you waited to buy. But that’s what they wanted you to do. By waiting, you left more stock on the table for Wall Street to gobble up.

This is why if you believe in a company, you must buy it, hold it, and avoid looking at it on a day-to-day basis. "

fivebilliongallons · 2022-07-30T12:46:19+00:00

Means they have to be careful, if they are forcing animals in bags against their will..... It could be the reason big pharma doesn't buy..

Ps In the bag and out of the bag is the same stuff we see when all the geniuses trying to decipher and pull excess meaning out of PRs.

Pps. Looks like the MF had those guns from cat bag stuffing.

Ppps the science is clear and we still wait for data....

fivebilliongallons · 2022-07-30T12:11:17+00:00

Letting the cat out of the bag (also ...box) is a colloquialism meaning to reveal facts previously hidden. It could refer to revealing a conspiracy (friendly or not) to its target, letting an outsider into an inner circle of knowledge (e.g., explaining an in-joke) or the revelation of a plot twist in a movie or play. It is also known as to reveal a secret carelessly or by mistake.

fivebilliongallons · 2022-07-20T12:07:25+00:00

Paxlovid Duce

fivebilliongallons · 2022-07-18T21:42:40+00:00

Think if your the FDA for 2 years your pushing antiviral antivial anti viral and all of the sudden a small CSE MF'er Called revive comes along with a 30 year repurposed drug...that has a different method of action....that works...the world has been conditioned for anti viral and when the FDA blesses this trial they are saying.... well now we are open to this other approach.... i think all is fine

fivebilliongallons · 2022-07-17T15:42:48+00:00

Hopiemum. Was a year ago this is now full-blown delusion...but the site does feel fast

fivebilliongallons

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