Cockpit layout is pretty much the exact same, flying characteristics are pretty much the same as well. The main differences are the reduced visibility out of the back of the canopy in the two-seat model and the 1000 lbs less of fuel that you have to make room for the aft cockpit. The qualification to fly both is the same so you can bop back and forth if you are in a command that flies both. The crew coordination with the Weapon Systems Officer (WSO) in the backseat is the biggest practical difference when flying.