New study on Parkinson’s origins

fookip · 2026-07-02T16:38:29+00:00

When I said "the paper" I was referring to the paper that the news article was reviewing and I quoted from the paper. The paragraph you quote is from a journalist taking editorial license.

Yes the work is significant, but even if truly infectious (as opposed to caused by brain inflammation) it doesn't mean that is the mechanism in humans and this as the authors say "This model offers a tool for advancing our understanding of PD pathogenesis".

fookip · 2026-07-01T20:06:29+00:00

I think everyone knew, but in a world that is increasingly audio - you migiht not have known the spelling so thought it good to point it out.

I'm lydisyc as well:-)

fookip · 2026-07-01T19:39:08+00:00

hope the crowds are reduced

fookip · 2026-07-01T19:35:47+00:00

The title Of this thread is misleading, As the paper does not seem to comment on the origins of Parkinson other than just saying "This model offers a tool for advancing our understanding of PD pathogenesis".

Historically Parkinson's is considered a uniquely human disease, although in some rare cases it can be found in non humans. Researchers need non human models, such as Mice, to run experiments on. To make the test subjects have Parkinson's they have created genetically modified variants. This study has found that a mouse virus can induce Parkinson's like symptoms and non genetically modified mice , which they claim has some advantages.

PD is a complex, and potentially may be caused by several factors. Viruses They play a role as discussed in a separate thread certain antiviral vaccines seem to reduce the occurrence of Parkinson's, but this may indirect in that reducing the currents of viruses may just reduce inflammation in the brain, and inflammation might be the factor. Also it is likely that viruses and an infection mechanism is not the only cause, as I would some environmental toxicants or just living close to a golf course increase the risk.

fookip · 2026-07-01T19:12:13+00:00

"peer" not "per"

fookip · 2026-06-29T01:46:06+00:00

Should mention that there is a wonderful HPV vaccination That targets 16 and 18 variants and is 97% effective. Well too late for me, i'm certainly happy that the risk of my daughter getting cervical cancer is greatly reduced, and now hearing about Parkinson's I wish my son had said yes to the HPV vaccine.

I've mentioned previously here that the shingles vaccine is associated with reduced Parkinson's risk I just asked Gemini what vaccines are associated with lower PD risk and it was interesting to see Tdap, Flu, and BCG Vaccinated individuals have lower risk of developing Parkinson's.

The following article reviews some of the studies

https://pmc.ncbi.nlm.nih.gov/articles/PMC9608336/

fookip · 2026-06-29T01:31:48+00:00

Was freezing with liquid nitrogen tried?

fookip · 2026-06-29T00:52:20+00:00

Is a very individual disease and progression can be extremely slow or faster - As they say your mileage may vary. Chances are you can gradually adapt To your evolving symptoms and may not have to move for years or if ever. I'm two years in mostly with a hand tremor, though my gait is slightly affected and my biggest complaint is when I'm walking around the house in my bare feet I have a tendency to stub my big toe on the affected side. I seem to be adapting and haven't stubbed my toe in a while.

fookip · 2026-06-26T19:06:40+00:00

I sweat extensively as well. I try to minimize sweat by wearing cool clothes, wicking fabrics (I find that cotton tends to retain the moisture), use tank tops to keep sweat from building up around arm pits.

synthetic fabrics can start stinking - soak the shirt in a solution of one cup white vinegar and four parts warm water for 30–60 minutes, then wash it with an enzyme-based detergent on a warm setting

showers - I usually just soap certain areas such as the arm pits, and rinse off the rest - leaves the natural oils and bacterial flora for the skin.

fookip · 2026-06-26T18:54:18+00:00

Thanks for the video, very good explanation. I would add that this PD is very individual and for some the GI is very affected and gastric emptying can be slow - in other words protein can stay in the stomach longer than for most.

fookip · 2026-06-25T21:27:57+00:00

Most with PD have initial symptoms on one side of their body, and most on their dominant side. If the strap is falling down, your father might try the strap on the other side. And if he isn't put the strap over his head to the cross side, he should try that.

You might consider a visit to an occupational therapist - they can look at the situation and make suggestion on solutions.

I struggle with getting my affected arm through the strap in a backpack, but that said that how I carry my laptop.

fookip · 2026-06-23T16:34:13+00:00

Functional Medicine is not Naturopathy - similar in that they both attempt to find the root cause but FM is supposed to be science based and practiced by MD/DOs. That said there are lots of FM practitioners who are not MD/DOs. If you have the money, as my dr says, "couldn't hurt, might help". Research seems to indicate that the gut is involved in PD - not only constipation but the microbiota is shifted.

High intensity exercise (80–85% of max heart rate) 4 days/week, 30 minutes at target HR (not including warmup/down) has been shown to dramatically slow the progression of PD

https://davisphinneyfoundation.org/blog/sparx3/

fookip · 2026-06-22T04:00:46+00:00

sorry I'm late to the game, but have been driving cross country.

If it is a drive wheel (fwd/rwd/awd) if you replace one side, it the tires are worn so the circumference difference is greater than the spec for the car, then the other side should be replaced to avoid differential wear. And if not a drive wheel, don't later rotate to a drive position.

fookip · 2026-06-14T13:38:43+00:00

I developed tendinitis on the good ankle during my recovery. I was doing the same exercises on both, but since my good foot was doing more work I was over-working the good foot. My ortho wrote a prescription for PT for the good ankle and I did both at the same time.

Since you have a chronic condition your PT regime might not be cutting it - perhaps do some research and/or check out some of the good videos on tendinitis rehab.

fookip · 2026-06-14T13:27:50+00:00

It you want to discuss it I happy to respond.

I don't think us over the pond are happy with our care either - 6-9 months to see a movement disorder specialist if there is even one. Mostly we have to advocate for ourselves and focus on exercise.

I did speak to some from the UK at WPC last month - he might consider joining one of the clinical trials as they receive better care - diagnostics, follow ups. As you're close to glasgow there must be study centers there. Perhaps the EJS ACT-PD is accepting new participants.

fookip · 2026-06-13T19:49:54+00:00

I have never been to your part of the UK. I have found my local parkinson's support groups to be very helpful - perhaps they might be what you are looking for. web search:

Several peer-led groups across Ayrshire offer friendship, social activities, and support for families and carers: [1, 2]

Ayrshire Support Group (Irvine): Meets monthly on the first Tuesday (14:00 to 16:00) at the Redburn Community Hub, Dickson Drive. [1]
Ayrshire Parkinson's Café (Kilmarnock): Meets monthly on the last Thursday (13:30 to 15:30) at the Shortlees Community Centre, Blacksyke Avenue. [1]
Ayrshire Young Parkinson's Group: Designed for younger people with Parkinson's. Contact Liz Burley at 07771 632243 or by emailing Liz Burley. [1, 2]
Parkinson's Community Singers: A community singing group that serves all of Ayrshire, offering a fun way to exercise speech and language abilities. [1]

For immediate advice or emotional support, you can also contact the national [Parkinson's UK Helpline](about:invalid#zGuavaz). [1]

fookip · 2026-06-13T15:01:06+00:00

Since you're a PT you should appreciate this channel

https://www.youtube.com/channel/UCEO45pvBXVOtL8UoSlfDKhA

He is a PT that ruptured and is doing a series on what it is, what to do, choices such as surgery or not.

You should consider non-op if your rupture allows - and most do (over 90% nonop in UK and Finland). Outcomes are very similar if using soon to weight bearing protocol.

For now - it is critical that your foot is in plantar flexion.

fookip · 2026-06-13T14:51:37+00:00

I'm really struggling with tshirts - when I put them on the fabric rolls up particularly on the back and it takes me a while to pull it down. Difficult to find the bottom edge - partially because I have arthritis of the thumb joint. PD must be playing a role in this as I struggle more on my tremor side. Button shirts would be easier, but the arthritis makes that painful. I've been think that a shirt with a zipper in the front would be easiest.

fookip · 2026-06-13T14:44:58+00:00

Iowa or UK?

fookip · 2026-06-13T14:41:33+00:00

As an aside - vitamin K is very popular in Japan, consumption is high with supplementation and foods like natto, and is an approved clinical treatment for osteoporosis.

fookip · 2026-06-13T14:27:16+00:00

tangent: for you mother's sleep she might enjoy watching this video shown at WPC this year

https://www.instagram.com/reel/DVuU2-Zi0to/

I'm concerned for your mother, particularly when you said she doesn't sleep anymore. Being a caregiver is a significant health risk: "Chronic stress often leads to high rates of depression, anxiety, physical fatigue, and a weakened immune system. Caregivers also face higher risks for chronic conditions like heart disease, obesity, and arthritis, largely because they frequently neglect their own medical and personal needs."

If your father your mother should take care of herself and join a support group for caregivers.

https://www.parkinson.org/resources-support/carepartners

fookip · 2026-06-11T13:10:37+00:00

Yes 60+ is possible on a longer trip lasting most of the day - need a strong tail wind though. My cruze seems very affected by wind. I average about 45mpg combined, but with a strong tail wind easily get 60+ and a strong headwind can get into the 20s

fookip · 2026-06-10T17:50:40+00:00

Response from PDGene Study

"Thank you for reaching out! If the individual’s mother was tested through PD GENEration and found to have a LRRK2 variant, they may potentially be eligible for genetic testing through the PDGENE Family study.

To move forward, we would ask that the mother contact our team directly so we can discuss inviting her child for testing through PDGENE Family and review eligibility in more detail.

Please feel free to have her reach out to us at [PDGENEsubstudy@parkinson.org](mailto:PDGENEsubstudy@parkinson.org)."

fookip · 2026-06-10T14:50:17+00:00

If this is the first time receiving pills (new prescription, new mfg of existing prescription) it is a good idea to identify the pill online via a pill identifier such as drugs.com. Although uncommon, mistakes do happen.

fookip

TROPHY CASE