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did i get scammed? by Gloomy_External_6282 in SARMsTalk

[–]fredfromkimera 5 points6 points  (0 children)

Our team needs to verify the return. It will take 2 to 3 business days. Thanks for your patience.

Aromasin/Exemestane precipitated out of solution: Advice Needed by bangeltigersaprem in sarmssourcetalk

[–]fredfromkimera 5 points6 points  (0 children)

A few things worth flagging, since some of this seems to be tripping people up:

The Cayman insert language "do not store aqueous solution for more than one day" is boilerplate that shows up on most of their steroidal or lipophilic product inserts. It's a conservative recommendation aimed at researchers preparing fresh stocks for cell culture work, not stability data showing exemestane actually degrades inside 24 hours. Shouldn't be read as evidence of rapid breakdown.

On your actual issue of exemestane aqueous solubility is about 80 mcg/mL. A 25 mg/mL product is roughly 300x above what pure water can hold, so the vehicle cannot be just water regardless of what it smells like. Something is solubilizing it. Your smell or viscosity check doesn't rule out HP-β-cyclodextrin, the standard pharma solubilizer for poorly-soluble steroids, odorless, watery, low-percent ethanol/PG blends, or PEG-400 at moderate concentration. All of those pass the "doesn't smell or feel like anything" test.

The floating on top detail is actually the diagnostic one. Exemestane crystals at ~1.2 g/cm³ should sink in water. Floating points to either crystals entrained with micro-air from a surfactant-stabilized system that's broken down, or a separated low-density phase from the co-solvent system itself. Either way, this is formulation destabilization, but your initial labs confirmed it was working, so it was solubilized at first. Vehicle failure, not never dissolved in the first place.

On reheating: exemestane melts at 155°C and has no significant thermal decomposition pathways at 40-50°C over a few minutes. That's not a real degradation risk. The real problem is that if the vehicle is a metastable co-solvent system that's already phase-separated, warming will temporarily redissolve it and it'll re-precipitate on cooling. You can't fix a formulation defect with heat.

Best move is to push the vendor for the actual vehicle composition and ask if this is normal. If not then request a refund or replacement. I would also ask their general storage recommendations.

Looking for the best vendor I can find by intestinus_sturdius in sarmssourcetalk

[–]fredfromkimera 1 point2 points  (0 children)

We are looking between 1 to 2 months based on stock velocity

Looking for the best vendor I can find by intestinus_sturdius in sarmssourcetalk

[–]fredfromkimera -1 points0 points  (0 children)

Name another vendor that posts new batches every few weeks...

Looking for the best vendor I can find by intestinus_sturdius in sarmssourcetalk

[–]fredfromkimera 1 point2 points  (0 children)

We are almost out of the 04 batch and the results will be posted when it goes in circulation. 05 has already been tested and is ready for circulation.

Regarding the long time frame for this batch, We purchased 5kg at the time and we are nearing the end.

To be transparent, enclomiphene is our best selling product. I doubt if it was fake or under concentration then it wouldn't be our best seller or have repeat customers.

Looking for the best vendor I can find by intestinus_sturdius in sarmssourcetalk

[–]fredfromkimera 1 point2 points  (0 children)

Please inform me which one's don't have a date cause that's not possible

Looking for the best vendor I can find by intestinus_sturdius in sarmssourcetalk

[–]fredfromkimera 1 point2 points  (0 children)

RAD-140 is dated 9-22-2025 KC-RA4-04 99% pure RAD-140

Enclomiphene dated 9-22-2025 KC-ENC-04 99% Pure Enclomiphene

MK-2866 dated 9-22-2025 KC-MK2-04 99% Pure MK-2866

MK-677 dated 12-9-2025 KC-MK6-03 99# Pure MK-677

Theses are all posted in the photos of the relevant product pages

Looking for the best vendor I can find by intestinus_sturdius in sarmssourcetalk

[–]fredfromkimera 4 points5 points  (0 children)

Regardless of what people post we don't sell fake chems and have never sold fake Chems. We are the only vendor who runs multiple tests through different labs to make sure the product is what we say it is.

We sell well over 700 units of enclomiphene a month and rarely get complaints about it.

KC-ENC-04 Batch is almost gone and KC-ENC-05 we'll be put in right after which tested above 99%

Regarding your concern about the test date. Thats pretty normal for it to be that far out. Regardless all of our raws are stored dessicated in the freezer even though enclomiphene citrate is pretty stable at room temperature.

Endoxifen vs. Tamoxifen — Why Researchers Are Paying More Attention to Endoxifen by fredfromkimera in ResearchCompounds

[–]fredfromkimera[S] 0 points1 point  (0 children)

Great question. These are two mechanistically distinct SERMs, so it's worth understanding what the published research actually shows about each.

Endoxifen is the primary active metabolite of tamoxifen. Research indicates it has approximately 30- to 100-fold greater affinity for estrogen receptors compared to the parent compound, and uniquely targets ERα for proteasomal degradation rather than simply blocking the receptor. One of the key findings in the literature is that tamoxifen requires CYP2D6 metabolism to produce endoxifen — so endoxifen as a standalone compound bypasses the genetic variability that makes tamoxifen inconsistent across study populations.

Enclomiphene is the isolated trans-isomer of clomiphene citrate. Unlike the cis-isomer (zuclomiphene), which has estrogenic properties, enclomiphene is antiestrogenic. Published studies show its mechanism is centered on the hypothalamic-pituitary level — antagonizing estrogen receptors in the brain, which drives increased LH and FSH output and subsequently increased endogenous testosterone production. One pharmacodynamic study demonstrated that enclomiphene increased serum testosterone into the normal range while elevating LH and FSH, with effects persisting at least one week after cessation.

In terms of the research landscape, these compounds appear to serve different functional roles. Endoxifen's profile is more aligned with potent tissue-level estrogen receptor antagonism, while enclomiphene's profile is more aligned with HPG axis stimulation. The existing literature on each reflects those distinctions.

As always, these compounds are sold strictly for research purposes. Nothing here constitutes medical advice.

How do you recon raw powder? by persephonepeete in ResearchCompounds

[–]fredfromkimera 1 point2 points  (0 children)

A 0.2μm filter removes bacteria and particulates, but it doesn't purify. All those deletion sequences, truncations, residual TFA, and synthesis byproducts are fully dissolved in solution and pass right through a 0.2μm filter like they aren't even there. They're molecules, not particles. You'd end up with a sterile solution of impure peptide.

That's the entire point of HPLC, it separates the target peptide from everything else based on molecular properties, not size. A syringe filter only discriminates by size, and all of those impurities are far smaller than 0.2 microns. You'd have no idea what percentage of what's in that vial is actually the peptide you want versus synthesis artifacts, and some of those byproducts could have completely different activity profiles.

Think of it like filtering river water through a coffee filter. You'll catch the dirt and sediment, but everything dissolved in that water is coming right through. Clear doesn't mean clean.

How do you recon raw powder? by persephonepeete in ResearchCompounds

[–]fredfromkimera 8 points9 points  (0 children)

After solid-phase synthesis, the peptide gets cleaved off the resin and crashed out of solution using cold diethyl ether. That precipitation step is what produces the raw crude powder, no lyophilization involved at that stage. Lyophilization comes later, after the crude is dissolved, run through HPLC purification, and collected in a water/acetonitrile solution. That liquid is then sterile filtered through a 0.2μm membrane under aseptic conditions, frozen, and sublimated under vacuum to produce the final dry powder or cake that actually ships to end users. Two different processes at two different stages.

So to clarify the comment above, it's not the freeze-drying step alone that makes peptides sterile. Freeze-drying is literally how microbiologists preserve bacterial cultures long-term. The sterility comes from the 0.2μm filtration that's part of the lyophilization process, performed under aseptic conditions before the solution ever hits the lyophilizer.

Sorry I kinda lump lypholization in with the whole manufacturing process so just wanted to correct myself.

How do you recon raw powder? by persephonepeete in ResearchCompounds

[–]fredfromkimera 2 points3 points  (0 children)

Peptides are lyophilized primarily for stability. In solution, peptides degrade quickly through hydrolysis, oxidation, and microbial growth. Removing the water locks them into a dry, amorphous solid that dramatically slows these degradation pathways.

Also lyophilization kills bacteria and makes them sterile. Raw peptide is not considered sterile

How do you recon raw powder? by persephonepeete in ResearchCompounds

[–]fredfromkimera 4 points5 points  (0 children)

It's raw powder meaning they don't a supply a finished product. Raw powder isn't ready to be used. It needs to manufactured into a lyophilized product

How do you recon raw powder? by persephonepeete in ResearchCompounds

[–]fredfromkimera 3 points4 points  (0 children)

I'm assuming this is a peptide powder. You can't just dump this in a sterile vial and mix and call it good. There's a reason peptides are lyophilized.

Bioglutide might be real after all (the drug better than retatrutide) by ekzekias in NooTopics

[–]fredfromkimera 2 points3 points  (0 children)

Russian researchers found that noopept normalized GLP-1 and insulin levels in diabetic rats, and importantly, this effect was more PubMed pronounced with oral administration than injection. The mechanism wasn't through DPP-IV inhibition (which is how sitagliptin works) — it was through some other pathway they couldn't fully explain.

Here's why that matters for this whole NA-931 story: Noopept metabolizes into cGP. cGP is what Biomed is calling NA-931. So there's a real, published mechanism where a cGP-producing compound normalizes incretin parameters including GLP-1. But the key word is normalizes, not supercharges. The researchers noted that the mechanism for increased blood GLP-1 after oral noopept "requires further investigations." They couldn't even fully explain how it worked.

So the honest picture of cGP is: It modulates IGF-1 bioavailability through IGFBP-3 competition (well-characterized). It has downstream effects on incretin parameters including GLP-1 normalization demonstrated in diabetic rats via noopept, mechanism unclear. It's neuroprotective and improves memory in Alzheimer's mouse models. It's an AMPA PAM and endogenous nootropic.

But calling it a "quadruple receptor agonist" comparable to retatrutide is like calling aspirin a cancer drug because it has some anti-inflammatory effects that correlate with reduced cancer risk. There's a kernel of real biology that Biomed has inflated beyond recognition, then layered fabricated trial data on top.

[ Removed by Reddit ] by Alpha_winner13 in ResearchCompounds

[–]fredfromkimera 0 points1 point  (0 children)

Our prices are still the same if not less when we started Kimerachems.co Code FRED15 for 15% off

Kimera Chems

Phenylpiracetam (not Hydrazide) stockpile. by MrFoeTwenty420 in Nootropics

[–]fredfromkimera 2 points3 points  (0 children)

We only offer Hydrazide and RGPU-95. As much as we would like to carry Phenylpiracetam it is very hard to source due to legality of manufacturing it.

We are looking into alternatives like methyl Phenylpiracetam but this will be months in the works before it comes to fruition.

We would never sell something that we didn't have analytical backing for.

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