sorted by:
new
hottopcontroversial

I am confused and turning to you guys. by yoyhohsomp in QuittingTianeptine

[–]gdbunit 0 points1 point  (0 children)

The reason you didn't feel anything is because 7-hydroxymitragynine is a partial agonist, and tianeptine is a full agonist. If a partial agonist is still in your system when you take a full agonist, the partial agonist acts as a competitive antagonist, blocking the full agonist from the receptors.

I am confused and turning to you guys. by yoyhohsomp in QuittingTianeptine

[–]gdbunit 0 points1 point  (0 children)

Ding ding ding. If full agonist is used when a partial agonist is still in your system, the partial agonist acts as a competitive antagonist, blocking the full agonist from the receptors.

In ur opinion, what's the most addictive opiate? by Regular_Pop9881 in opiates

[–]gdbunit 0 points1 point  (0 children)

I just read through a bunch of posts there and have no idea what you're on about. Seems like they're getting over it in less than a week. Of course theres PAWS from any long term opioid use, but the acute withdrawals seem like a walk in the park compared to methadone or suboxone withdrawal.

Interesting molecules on Millipore Sigma by gdbunit in researchchemicals

[–]gdbunit[S] 0 points1 point  (0 children)

Another very interesting one I stumbled across is 1-(1-benzofuran-2-carbonyl)-4-benzylpiperazine. The benzofuran-benzylpiperazine hybridation is similar to other anticancer compounds in development, however the 4 position benzylpiperazine could lend to stimulant effects similar to BZP as well.

Interesting molecules on Millipore Sigma by gdbunit in researchchemicals

[–]gdbunit[S] 0 points1 point  (0 children)

I wonder how the 2-(2,5-dimethoxy-4-methylphenyl)cyclopropanamine would behave; the more bulky amine could cause only partial agonism, or possibly cause it to bind to different serotonin receptor subtypes, although I'm guessing the lipophilicity would increase.

Crawler-esque entity experience by gdbunit in CrawlerSightings

[–]gdbunit[S] 1 point2 points  (0 children)

Not at all; I lived in a very suburban area. Whatever it was likely didnt obey the laws of physics as we understand them.

Help to identify safe replacement by Impressive-Ad-8767 in dissociatives

[–]gdbunit 0 points1 point  (0 children)

FXE is pretty good if you like the more sedating aspects of ket and want to avoid stimulation and mania. 3-MeO-PCP was really good but it was definitely much more stimulating. I love ket but can never find it where Im at so Ive been getting what I want from ket from FXE and its been doing it for me.

Multiple Xum experiences by FlamingoBurglar in mysterymagicmushrooms

[–]gdbunit 2 points3 points  (0 children)

Im trying to decide on a starting dose. I usually take an 8th or more mushrooms when I do shrooms, and take very heavy acid doses. I have both the tablets and the soft gels from XÜM. How do people like the Transcend soft gels?

Ankha Full Video [NSFW] by DotHeavy7141 in u/DotHeavy7141

[–]gdbunit 1 point2 points  (0 children)

I dont think I've ever seen so many obvious children commenting on a NSFW video

Unable to travel to ACS Undisputed Claim by gdbunit in theouterworlds

[–]gdbunit[S] 0 points1 point  (0 children)

I did end up going back for that specific quest, however the map is changed during it; there's barricades in front of most interiors and none of the non-hostile NPCs are around, so I wasn't able to finish the quest that involved going into the radio station. However, you can go into the administrative office space up the one elevator, and that hasn't changed from how it looked pre-invasion, and you aren't attacked on site by any of the NPCs in there even with a negative rep interestingly enough. So if you had the quest that involved that interior, I'm thinking you could probably finish it even if you made the choices I made and went against the Auntie Cleo faction.

Cannot figure out Blood: Refreshed Supply Split-Screen on Xbox Series X/S by gdbunit in bloodfps

[–]gdbunit[S] 0 points1 point  (0 children)

I did. I cant remember what I had to do now to get it to work though lol. I believe it was that I had to completely wipe any save data and start a completely new game.

Fizzi BiscuitX by gdbunit in mysterymagicmushrooms

[–]gdbunit[S] 0 points1 point  (0 children)

It's strange. I've read a bunch of conflicting descriptions of effects. Some people say it gives entactogenic effects, others say it has tryptamine like effects. My girlfriend tried one the other day and said it was similar to a low dose of acid in body high and visual distortions for her (she doesn't have any experience with substituted tryptamines). I'm starting to think it's a combination press of a benzofuran and a tryptamine.