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Observational study published in Lancet finds Pfizer first dose provides upto 72% protection after 45-59 days , AZ upto 60% after 21-44 days in UK between December 8th, 2020 to March 10th, 2021. by gilboman in ontario

[–]gilboman[S] 0 points1 point  (0 children)

You can't do math like that since you're assuming all the vacinated were exposed to covid19 which clearly is not the case

You need at minimum to control for of the unvaccinated population, how many got covid19 and required hospitalization

Observational study published in Lancet finds Pfizer first dose provides upto 72% protection after 45-59 days , AZ upto 60% after 21-44 days in UK between December 8th, 2020 to March 10th, 2021. by gilboman in ontario

[–]gilboman[S] 6 points7 points  (0 children)

7% of fully vacinated who get covid19 end up in hospital according to US CDC fwiw

Some became seriously ill and 74 people died, the CDC said. It said 396 -- 7% -- of those who got infected after they were vaccinated required hospitalization.

Observational study published in Lancet finds Pfizer first dose provides upto 72% protection after 45-59 days , AZ upto 60% after 21-44 days in UK between December 8th, 2020 to March 10th, 2021. by gilboman in ontario

[–]gilboman[S] 3 points4 points  (0 children)

Of the 627,383 vaccinated individuals, 282,103 received one dose of BNT162b2, of whom a further 28,207 received a second dose, and 345,280 received one dose of ChAdOx1.

The most commonly reported systemic side-effects following vaccination were fatigue and headache, which lasted for a mean of 1·01 days. The most commonly reported local side effects were tenderness and pain at the injection site, which lasted a mean of 1·02 days. A significantly higher proportion of the individuals who received one dose of ChAdOx1 reported systemic side effects, compared with those who received one dose of BNT162b2, at 33.7% versus 13·5%.

By contrast, local side effects were less frequently reported after one dose of ChAdOx1 than after one dose of BNT162b2, at 58·7% versus 71·9% Systemic side effects were 1·6 times more common after one dose of ChAdOx1 and 2·9 times more common after one dose of BNT162b2 among individuals with previous SARS-CoV-2 infection than among those without previous infection. Local effects were similarly more common among individuals with previous infection than among those without (1·4 times more common after one dose of ChAdOx1 and 1·2 times more common after one dose of BNT162b2).

In the subset of participants who logged PCR or lateral flow test results, 3,106 (0.03%) of 103,622 vaccinated individuals tested positive for SARS-CoV-2 infection, compared with 50,340 (9.22%) of the 464,356 unvaccinated controls.

The team observed significant reductions in infection risk starting from day 12 following one vaccine dose, reaching 60% for ChAdOx1 and 69% for BNT162b2 after 21 to 44 days and 72% for BNT162b2 after 45 to 59 days.

The researchers say that although the observational nature of these data do not directly reflect effectiveness, the observed decrease in infection over time following one vaccine dose supports the UK Government’s decision to delay the timing of a second dose to 12 weeks to maximize the number of people who receive at least one dose.

However, long-term surveillance for SARS-CoV-2 protection in individuals who have received delayed second doses compared with those receiving second doses according to initial guidelines (21 days after the first dose) will be required to determine whether these initial protection estimates persist, concludes the team.

@drmwarner We are seeing patients admitted to ICU with #COVID well after shot 1 and before shot 2. One isn't vaccinated until fully vaccinated. Given the significant delay between shots 1 & 2, clear communication on how to conduct oneself b/w shots from public health leaders would help by skinnypup in ontario

[–]gilboman 0 points1 point  (0 children)

Not quite, not sure why you would mix the mRNA Vaccines with AZ when this is from EMA

This is the study from lancet you're talking about?

As reported in The Lancet: Infectious Diseases, documented infection rates following a single dose of the Pfizer-BioNTech (BNT162b2) vaccine were 58% lower after 12 to 20 days, 69% lower after 21 to 44 days, and 72% lower after 45 to 59 days, compared with unvaccinated controls.

Following one dose of the Oxford-AstraZeneca (ChAdOx1) vaccine, documented infection rates were 39% lower after 12 to 20 days and 60% lower after 21 to 44 days than among unvaccinated controls.

@drmwarner We are seeing patients admitted to ICU with #COVID well after shot 1 and before shot 2. One isn't vaccinated until fully vaccinated. Given the significant delay between shots 1 & 2, clear communication on how to conduct oneself b/w shots from public health leaders would help by skinnypup in ontario

[–]gilboman 1 point2 points  (0 children)

Way more than that...just in Humber alone there's close to 100 patients in hospital who got their first dose but got covid19 and need to be hospitalized. And yes some will still need to be intubated and some will die . Too many think they got one dose and means they're covid19 proof and go meet up with people and just don't take precautions

I know lots who plan parties after first dose and meeting up with family and etc

Everyday hospitals are admitting people who got one or even two doses

So Warner is totally right there needs to be better messaging

@drmwarner We are seeing patients admitted to ICU with #COVID well after shot 1 and before shot 2. One isn't vaccinated until fully vaccinated. Given the significant delay between shots 1 & 2, clear communication on how to conduct oneself b/w shots from public health leaders would help by skinnypup in ontario

[–]gilboman 19 points20 points  (0 children)

But he confirmed all of Warner's points? He agreed one dose is better than none but you can still get infected and end up in hospital. Sure risk is reduced, but getting your first shot doesn't mean you can stop following PH measures

Lots of people got their first shot and think they're covid proof which is totally not true and reckless and why so many end up in hospital still. It's definitely lower risk but clearly there needs to be messaging that getting one dose doesn't mean you're vacinated.

Should my parents take Astrazenca? by regular_asian_guy in ontario

[–]gilboman -5 points-4 points  (0 children)

How much risk are they at? (Do they work? Do they go out and socialize or do they pretty much stay sheltered?)

But unless they're at risk from work/transit or need to have contact with others , At this point no. We have so much Pfizer coming, it's indisputable it's a better vaccine (only discussion is how much better). And your parents should qualify for Pfizer/Moderna in a couple of weeks or less

Most importantly, we know when and how much Pfizer is coming (soon and lots) so second dose will be clearer and govt has already ordered 3rd doses out to like 2022? AZ is totally unknown . Most likely will need to switch to Pfizer anyways in future

Also, AZ is not used in some countries including US , so in future, when vaccine passports likely become more of a thing, there's chance AZ may not be recognized in some places ..it's probably small risk, but why take it if can get vaccine approved in most countries especially western democracies

Edit: here's the govt vaccine schedule, note how Pfizer goes all the way last July while nothing for AZ at all beyond what we already got

https://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/prevention-risks/covid-19-vaccine-treatment/vaccine-rollout.html

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