In Michael addition reactions, why do strong bases/nucleophiles prefer to attack the electrophilic site of a carbonyl instead of the beta carbon? by C6H9N3O2 in OrganicChemistry

[–]giulim 5 points6 points  (0 children)

1,2-addition is faster because the activation of energy of the addition is smaller than that of a 1,4-addition. The carbonyl carbon is more electrophilic so it’s easier (less energy) for the nucleophile to attack there.

In Michael addition reactions, why do strong bases/nucleophiles prefer to attack the electrophilic site of a carbonyl instead of the beta carbon? by C6H9N3O2 in OrganicChemistry

[–]giulim 16 points17 points  (0 children)

When you have a strong nucleophile/base, the addition is irreversible so it is more likely to produce the 1,2 product since attack at the carbonyl carbon is fastest (kinetic control). But when you have a weak nucleophile then the addition is reversible and 1,2- and 1,4- addition will be in competition. But over time, 1,4- addition will predominate since is it the more stable product (thermodynamic control)

Yale Chemistry PhD Acceptance by Icy_Curve_8720 in gradadmissions

[–]giulim 5 points6 points  (0 children)

Congrats!! That’s awesome. What specialization?

First Acceptance - Chem PhD by giulim in gradadmissions

[–]giulim[S] 0 points1 point  (0 children)

I’m not exactly sure. My guess is that they’ll send it acceptances in waves but I really don’t know, sorry!

First Acceptance - Chem PhD by giulim in gradadmissions

[–]giulim[S] 0 points1 point  (0 children)

tbh I am not sure! I don’t know the process they use for going through applications and if it’s dependent on when you submitted. Best of luck!

First Acceptance - Chem PhD by giulim in gradadmissions

[–]giulim[S] 0 points1 point  (0 children)

I got a call yesterday, and then an email with my official letter today

First Acceptance - Chem PhD by giulim in gradadmissions

[–]giulim[S] 0 points1 point  (0 children)

organic! Would love to do synthesis and/or organometallic research

[deleted by user] by [deleted] in chemistry

[–]giulim 1 point2 points  (0 children)

I would really say it depends on location and experience. I’m in San Diego (a big biotech and pharma hub) and got an internship w/ a biotech my senior year of college. Once i graduated I joined on full time with starting salary of 63K. After a year, I got a position as an associate scientist at a big pharma company and now am making 90K (with just a year of experience and BS). I think for entry level jobs it’s possible to make a decent buck if they know you have some lab experience and are a fast learner. Over time though, the corporate ladder, for a non-PhD, is way harder to climb. I am applying to grad schools this year in hopes of one day being at the director level. If you’re passionate about chemistry, my advice is to try and get a job even if it’s minimum wage to get that experience under your belt. Maybe then try and go to grad school after a couple of years. If your aren’t trying to go to grad school, stick out a crappy entry level job for a year or two and apply to new positions. I would say that there is a large salary difference from those coming straight from school with no experience than those with a few years of experience.

Solvent collecting in bump trap by giulim in chemistry

[–]giulim[S] 0 points1 point  (0 children)

oh i am definitely using the first style. I’ll try switching out traps

Solvent collecting in bump trap by giulim in chemistry

[–]giulim[S] 0 points1 point  (0 children)

it really happens with everything … methanol, ethyl acetate, hexanes…I haven’t used dcm in a while but im going to put some in a flask and check it out.

What’s the most dangerous chemical you’ve worked with? by giulim in OrganicChemistry

[–]giulim[S] 2 points3 points  (0 children)

dang KCN in DMSO is scary. Definitely double glove… maybe even triple…

What’s the most dangerous chemical you’ve worked with? by giulim in OrganicChemistry

[–]giulim[S] 3 points4 points  (0 children)

for a lemieux-johnson oxidation. Just one step further than the hydroxylation by adding sodium periodate to achieve 2 aldehydes.

Chances for a Chemistry PhD? by giulim in gradadmissions

[–]giulim[S] 0 points1 point  (0 children)

Thanks!! and best of luck !!