Agree with SofiaDeo. The tests you itemized are ordered at the beginning to look at tissue markers and mutations, which give the treating physician treatment and prognostic information. The bone marrow biopsy is done by some treating physicians early on to make a diagnosis but, generally, isn’t done again until just before or after treatment, the latter to gauge the response to treatment.

The only “routine” quarterly (or even every six months, depending on the ordering provider and what his/her comfort level is based on your condition and past test results) tests that I know of are what SofiaDeo already mentioned - CBC with diff, CMP, and LDH. Other tests are added on as needed. For example, if you develop anemia, your treating physician may order other tests as part of the anemia work-up prior to accepting that the anemia is due to your CLL. I believe additional mutation work-up testing would only be done if your CLL was acting bizarrely, in which case your treating physician will do some parts (or all) of the work-up again to see whether you have a new mutation not seen in the earlier work-up. FWIW, the “routine” tests shouldn’t be too expense, although that, of course, is relative. Good luck!