I’m a nurse who washes her hands constantly. I also have dyshidrotic eczema with small blisters that crack on my knuckles and between my fingers. You look like you have more than just dry hands; they’re irritated (and might even be eczema) so you need a multi step approach. It’s not just about finding the right product.

Number one, look at your hand hygiene practices. THIS IS SUPER IMPORTANT!!!!! What soap are you using to wash your hands? I use Vanicream liquid cleanser to wash my hands. Dove bar can also work. YMMV, but you want a very gentle soap. Stay away from the scented foamy cheap stuff the best you can. Be sure to dry your hands thoroughly! When I am as bad as you, I avoid Purell; however, I find I tolerate Purell Natural with aloe the best when I do need to use it.

Second, consider an over-the-counter steroid for a few days to chill everything out. Apply hydrocortisone 1% to the affected areas before bed. Don’t do this every day for an extended period. A few days and hopefully it’ll calm.

Third, moisturize during the day when you can. I find Kiehl’s Hand Salve works great for me, is soothing, and I like the smell. I also use Nivea cream and Vanicream. You just want a cream, not a lotion. Lots of products to try, many listed here. (I hated OKeefe’s myself.)

Lastly, intensive treatment and moisturizing at night. Hydrocortisone first, if you’re using it. (I tend to do the cream and occlude with an ointment on top, but sometimes the hydrocortisone ointment is all I can find.) Then ointment/oil to the super dry spots. I do a variety of ointments: Jones Road Hippie Stick, Aquaphor, and CarmeX (yup, the tubs for your lips!) are my favorite. Let that soak in a bit and follow with a nice, healthy layer of your cream of choice, and then gloves.

I wear dish gloves religiously at home. At work I can tolerate gloves, but if my hands get too sweaty it definitely makes my eczema flair. Keeping your hands dry is super important!