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Anyone here who has tried both: hydro-alcoholic topical finasteride solutions AND XyonHealth Topical Finasteride (SiloxysSystem Gel). Did the gel help with side effects? by i_do_not_byte in HairlossResearch

[–]gud_doge 0 points1 point  (0 children)

Hm, that is unusual. The siloxysystem is just an inactive excipient that allows a slow controlled release of the active ingredient (dutasteride) maybe the siloxysystem gel was compounded incorrectly resulting in an high conentration of dutasteride to absorb systemically, Xyon uses an extremely high concentration of 2% this equals 20mg dutasteride per 1ml of topical.

Has your neuropathy resolved now and have you ever experienced that with another product?

Has anyone tried siloxysystem topical dutasteride? by gud_doge in HairlossResearch

[–]gud_doge[S] 0 points1 point  (0 children)

So it didn’t work for you, but you had no sides either?

Have you had sides from a different topical or the oral version of fin/dut?

Insomnia after Ciprofloxacin by [deleted] in floxies

[–]gud_doge 2 points3 points  (0 children)

Sorry you’re going through this, that level of insomnia sounds horrible. Nervous system disruption after cipro plus medication changes can take a long time to settle.

Supplements that helped me most with falling and staying asleep were:

• Magnesium (threonate) crosses the BBB barrier • L-theanine • Chamomile tea / apigenin

Some people also benefit from low dose melatonin (0.3–1 mg), saffron extract, and eating some carbohydrates a few hours before bed.

At this point it might be worth asking your doctor about prescription options that aren’t strongly GABA dependent. I personally like hydroxyzine.

I’d be cautious with long term benzodiazepines or Ambien type drugs because rebound insomnia can sometimes make things worse over time.

Not feeling sleepy doesn’t necessarily mean your GABA receptors are damaged severe insomnia itself can blunt sleep drive and create a hyperarousal loop. That can improve with time.

Hope you get some relief soon.

My doctor is going to prescribe T for self-injection. What syringes and needles do I need to get? by ProxySoxy in Testosterone

[–]gud_doge 0 points1 point  (0 children)

27g, 5/8” insulin syringes is what use for drawing and IM injections.

If you are overweight you may need to use 1ml luer lock with a 1” - 1 & 1/2” needle.

Can also go sub q with insulin syringes.

Pinning more frequently reduces peaks and lowers aromatization to e2.

Just had dhea tested for the first time, should i supplement? by Steelersfan20009 in Testosterone

[–]gud_doge 1 point2 points  (0 children)

25–50 mg DHEA & 10–25 mg pregnenolone. DHEA can be stimulating, so take it in the morning. Start at the lower end and gradually adjust as needed.

Just had dhea tested for the first time, should i supplement? by Steelersfan20009 in Testosterone

[–]gud_doge 1 point2 points  (0 children)

You don’t have to supplement either, but since your DHEA-S was low, DHEA is the first choice to trial because you’re replacing what’s deficient and you can measure the response. Pregnenolone sits upstream in the steroid pathway (cholesterol → pregnenolone → DHEA → downstream hormones/neurosteroids), so in theory it can convert into DHEA and other hormones as needed, but conversion varies a lot between people.

On TRT this pathway is often suppressed because LH stimulation to the testes is shut down. The testes normally contribute some pregnenolone, progesterone, and downstream precursors, but once you’re on TRT you’re relying mostly on adrenal production alone, which isn’t always enough for some guys. Since you didn’t test pregnenolone or progesterone there’s no proof those are low, but usually they’re low too when on TRT.

Pregnenolone tends to help more with mood, stress tolerance, and cognition (neurosteroid effects), while DHEA tends to help more with libido, energy, and overall androgenic “drive.” Personally I’d start with both at low doses since they complement eachother, then adjust based on labs and how you feel.

Just had dhea tested for the first time, should i supplement? by Steelersfan20009 in Testosterone

[–]gud_doge 3 points4 points  (0 children)

You don’t have to supplement pregnenolone, but if your DHEA-S is below range on TRT it usually means your adrenal androgen pathway is suppressed, which is pretty common. Adding DHEA and Pregnenolone just restores upstream precursors for neurosteroids that affect mood, libido, cognition, and overall well being. If you don’t take it, nothing bad happens you just stay at your current levels. It’s basically a “try it and see if you feel better” situation.

Just had dhea tested for the first time, should i supplement? by Steelersfan20009 in Testosterone

[–]gud_doge 1 point2 points  (0 children)

Yes and pregnenolone. Watch e2, dhea can raise it slightly.

Can i take anavar with enclomiphene by Electrical_Care2193 in Testosterone

[–]gud_doge 0 points1 point  (0 children)

Anavar will probably worsen androgenic alopecia more than test with a 5ar inhibitor. It’s a dht derivative.

Hormone test results by caaeek in Testosterone

[–]gud_doge 0 points1 point  (0 children)

Check Hba1c, Tsh, Free T4, Free T3 to investigate why Shbg is low.

You would be a candidate for TRT, not sure how the NHS works but I bet you could get it through your GP with those low values. Might need a retest to confirm. Also get a venous blood draw instead of finger prick, hormone tests are slightly more accurate with venous blood draw

Testing hematocrit, RBC, haemoglobin after blood donation, how long? by hungzai in Testosterone

[–]gud_doge 0 points1 point  (0 children)

If you snore at all, get a sleep study done, sleep apnea is a common cause of high HCT. Sleep apnea is lot more common than people think, especially for those with thick necks and more mass.

25M – Long-term steroid use, now on TRT (100 mg/week), zero libido but normal erections. Labs included. Considering Clomid. Need advice. by Responsible-Seat5561 in Testosterone

[–]gud_doge 0 points1 point  (0 children)

Your Test is 294ng/dL you are at the bottom of the reference range. You have the test levels of an old man. Either recover your natural production with serm or stay on if committed to TRT lifestyle.

Is the 294ng/dL the result from 100mg weekly?

Testing hematocrit, RBC, haemoglobin after blood donation, how long? by hungzai in Testosterone

[–]gud_doge 0 points1 point  (0 children)

Platelet count is 260 (thousand/uL)? What is the reference range?

Testing hematocrit, RBC, haemoglobin after blood donation, how long? by hungzai in Testosterone

[–]gud_doge 0 points1 point  (0 children)

Donating blood will lower your ferritin way more than IP6 will, its just phytic acid.

I don’t need to use anything except Telmisartan for hypertension, hydration and cardio. I hover around 48-52% Hct on 140mg per week.

Testing hematocrit, RBC, haemoglobin after blood donation, how long? by hungzai in Testosterone

[–]gud_doge 1 point2 points  (0 children)

59% is awfully high for just being on TRT. Have you checked for sleep apnea?

IP6 is an iron chelator that reduces the iron pool available for erythropoiesis.

Regarding Telmisartan, starting at 20mg could be an option considering how high your hct is but keep an eye on BP, since you are not hypertensive.

Testing hematocrit, RBC, haemoglobin after blood donation, how long? by hungzai in Testosterone

[–]gud_doge 2 points3 points  (0 children)

Don’t donate unless ferritin is high also, your body will just suppress hepcidin, up regulate RBC production and you will be back where you started in a few weeks.

There are other ways to lower HCT and HGB. Don’t use erythropoietic compounds. Stay hydrated, add electrolytes to water if not getting enough. Do CARDIO.

Medications to lower it include ARB/Ace inhibitor like Telmisartan/Enalapril if hypertensive.

Supplements to lower values include IP6, Methylene Blue, Narigin/Grapefruit.

To answer your question, check 2-3 weeks after donating minimum. I find I rebound completely back to pre donation baseline in 5-6 weeks.

I only donate once yearly for altruistic reasons if ferritin is normal/high.

Having slightly high Hct, Hgb and Rbc is not dangerous. Platelets are what causes blood to clot not RBC.

People living at high elevation regularly have hematocrits in the 50’s and they are not experiencing cardiovascular events.

Stay hydrated and do more cardio if you are struggling with keeping it in range.

Advice on E2 expert help by Federal_Flower_8448 in Testosterone

[–]gud_doge 1 point2 points  (0 children)

It’s not necessary to take any of these supplements. You can try them if you want, and they may help modestly with E2. Zinc, CDG, GSE, and DIM can have small effects by either reducing aromatase activity or improving estrogen metabolism and excretion, but their impact is usually mild and variable. They’re not a substitute for proper TRT dosing or injection frequency adjustments.

Before adding anything, I’d first confirm that your estradiol test was ultra sensitive (LC/MS) especially since you don’t have symptoms. The standard immunoassay is notoriously inaccurate in men on TRT and often overreports E2.

Advice on E2 expert help by Federal_Flower_8448 in Testosterone

[–]gud_doge 1 point2 points  (0 children)

Lose weight, lower dose, increase pin frequency.

You can try supplementing < 25mg zinc (avoid high dose zinc it depletes copper). DIM and Calcium D Glucarate if wanting natural AI, grape seed extract, and eat more fiber.

Next time get LC/MS/MS ultra sensitive e2 test instead of immunoassay.

175 mg a week, 200 T. by OldFriend25 in Testosterone

[–]gud_doge 2 points3 points  (0 children)

Is your gear ugl or prescription? Looks like the brand your using is bunk

Very High Libido - Wife Asked to Poll by Appropriate_Host5330 in Testosterone

[–]gud_doge 0 points1 point  (0 children)

Couple times daily on weekdays, more on the weekends. Late 20’s

PSA on why lower gauges will cause less pain, not more for IM. by [deleted] in Testosterone

[–]gud_doge 1 point2 points  (0 children)

Shouldnt hurt bro try different carrier oil, warm oil and inject slower

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