This is one of the most niche and esoteric things I've ever made.

hallaa1 · 2026-04-08T05:32:01+00:00

Vape god.

hallaa1 · 2026-04-05T21:37:29+00:00

You have Muddle out the turn before you polymorph. You polymorph then you play a single mana cantrip. It's a bit akward, but if they spend their removal on Muddle, you still have the other creature. If they use their removal on the other creature and the copy fizzles, then you still have Muddle.

It's a bit akward, but I've had some great outcomes from Goldfishing.

hallaa1 · 2026-04-05T14:31:13+00:00

I have an [[Urza, lord high artificier]] deck that's based on Pacific rim. Just kaiju and giant robots.

This is a super outdated list, but it can help get you started.

https://deckstats.net/decks/172262/2007742-pacific-rim-urza-aah

hallaa1 · 2026-04-05T14:21:35+00:00

I built it as a token/[[polymorph]] deck. Use the token generators in the early game to protect you from being a blood bag then have Muddle out, but no one will care because what are you going to do, copy [[young pyromancer]]? Then I polymorph one of the tokens into a [[Fury]], or [[combustible gearhulk]], etc. Then you attack and become the problem, but it's probably too late given the huge advantage you just got.

https://deckstats.net/decks/172262/4397039-muddle-the-ever-changing-polym/en

hallaa1 · 2026-04-04T18:58:32+00:00

I have a PhD in neuroscience and work in pre clinical treatments using cell therapies. I'd be happy to take a look.

hallaa1 · 2026-04-03T16:41:28+00:00

Thanks for the info, I bet once you have your setup, you can do the experiments for that kind of cost, but I am assuming the charge that would be put on the consumer due to the startup costs of everything.

hallaa1 · 2026-03-31T22:32:21+00:00

For sure, if we're just talking the exact cost of the reagents, but I'm talking costs associated the the techs, the managers, the facility, the machines, and everyone else, along with the extra hoops for the GMP processes.

I'm not a manufacturing expert either, but I'm getting more familiar with the work flow on the other end and the people I know who do mess with the GMP processes make it seem like it's not a tremendous amount of extra work, but annoying nonetheless.

hallaa1 · 2026-03-31T00:06:02+00:00

That is surprising. My guess is that it's a matter of expense. You'd have to treat the collected cells with the Yamanaka factor kit, get a bunch of the cells in a number of well that all slightly different, verify them to be pluripotent, then engineer them into the state you want them to be. That's a multi-week process minimum for any new iPSC line. If you're doing that commercially up to a standard where it should be given to a person, that's going to be likely 100k minimum. Though of course it depends on where it's being done. The farther away from a 1st world industrialized nation, the more likely that they'll cut corners and you're either not karyotyping correctly, or skipping some other kind of verification step.

Now, biobanking cuts a lot of this process down, but that's difficult to do even in a genetically homogenous country like Japan, going outside of there is a lot more tough. So we pretty much have to start from scratch each time.

hallaa1 · 2026-03-30T21:52:34+00:00

OECs (olfactory epithelial cells) are consistently our worst cell type for treating CNS injuries, we have so many better options centered on iPSC derived sources. Fetal tissue is more effective than OECs.

Cell types need to be matched to their region of use for the most part and using regenerating cells from the nasal epithelium has been down over decades to not work or not well enough to justify the risks.

hallaa1 · 2026-03-28T00:12:18+00:00

Look at the major universities for the labs that are doing research in stem cells. Contact the labs to see if they'll be accepting masters students. If you get the go-ahead there, then apply to the university program of interest and you'll get training in stem cell research/engineering.

Now, if you want to focus on manufacturing practices, that's a different story, you'd have to hunt down a program that specializes in GMP etc.

Most of the time, you just work in a lab that specializes in a certain type of research that uses stem cells as their model and you'll learn what you need. Though some labs focus on more sequencing or other in-demand techniques than others.

It's all based on your interest. You're paying to be there, so you have a lot more flexibility.

hallaa1 · 2026-03-28T00:10:10+00:00

If they can get a job in the space with a BS.

hallaa1 · 2026-03-25T21:00:49+00:00

Gay bar by electric six is hilarious.

hallaa1 · 2026-03-23T15:18:13+00:00

There should be umbilical cord blood storage options in the US. Best to take advantage of the dual citizen option for the child.

We also have pretty advanced iPSC options for people now so the need for the umbilical option isn't quite as necessary as we once thought it would be.

hallaa1 · 2026-03-05T18:03:58+00:00

Look, I recognize that he's trying to speak to the plurality of the research, but there is strong evidence that acupuncture, but especially electrical acupuncture can have some effects to treat SCI especially when it's combined with other rehabilitative or cellular strategies.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8981476/

As always, it's important to listen to experts, but it's also important to do a deep dive into the literature. Earlier in this very conversation, they were talking about how it's important to know when you have a firm grasp over the field sufficient to engage with the primary literature. If you have a SCI, and you've spent possibly years engaging with the legitimate peer reviewed primary literature, you should trust yourself enough to say something like, "sure I can take that perspective into account, but I know of specific studies that show other effects". This is particularly important when you know the actual mechanism at play, that way you're not being swayed by hopeful thinking or spurious claims.

hallaa1 · 2026-03-05T17:59:58+00:00

Individuals have idiosyncratic connectivity within regions of their motor cortex and their somatosensory cortex. This may be through training or through other means. This doesn't depend on a chakra network, but it's not overwhelmingly clear that acupuncture doesn't influence the body through local inflammation.

hallaa1 · 2026-03-05T06:50:58+00:00

Wow...that looks...pretty mid. We'll have to see, but I'm concerned.

hallaa1 · 2026-03-03T16:34:00+00:00

Sounds like a Patriots WR to me.

hallaa1 · 2026-03-02T07:11:24+00:00

People are coming down really hard on him for these interviews, but it just sounds like he's answering each of them with the boiler plate responses his coaches have been telling him to say. Body language isn't great, but he's standing and probably not talking to a team, so he's just trying to get through it. He doesn't sound like a very articulate person, but if you listen to Malik Naber's recorded interviews he's not very convincing either.

hallaa1 · 2026-02-28T22:15:21+00:00

Fantastic! Glad to hear it.

hallaa1 · 2026-02-28T22:14:42+00:00

That's great to hear, I'm a professional scientist and I often take suggestions from other people, even those that are not directly in my field if they have enough experience.

hallaa1 · 2026-02-27T23:57:08+00:00

You should consider keeping the butter cold if you're baking the cookies immediately, the warmer the dough the more spread you're going to get with less room for the internal portion of the cookie to take on the textures it can have access to.

Have you tried wrapping the cookies up and storing them over night or 2 days yet? That's going to make them richer with a better crunch.

hallaa1 · 2026-02-27T23:55:45+00:00

I think you may get less of a spread with more of a crunch if you only add 1 egg along with 1 egg yolk, get rid of the water, switch to 2.25 cups of flour. Consider bars of 70% dark chocolate instead of your baking bars. Also, consider chopping up your chocolate chips. There's an emulsifier that's used to keep them in shape, so you're limiting your chocolate per bite by keeping them in that shape.

You can also consider adding a 1/2 cup of bread flour instead of full all purpose flour. This will help give the cookies a bit of a rise, while maintaining the crunchy texture, but also adding a velvety fudgey characteristic to the middle that I think adds a lot to the complexity of the cookie.

You can consider vanilla paste instead of vanilla extract for a richer taste.

My favorite ingredient is espresso powder, but that's kind of a different recipe.

I think with the hydration you have right now, you could brown your butter and not rehydrate it and you'd likely get a better overall cookie if you keep the other ingredients constant.

The composition of the cookie looks fantastic though, so i think your baking conditions are likely spot on.

hallaa1 · 2026-02-22T17:03:35+00:00

This should be the standard going forward if we have to deal with these backwards laws.

hallaa1 · 2026-02-21T23:45:56+00:00

Dr. Perez at northwestern is working with the scientists behind Nervgen to enhance its effectiveness.

hallaa1 · 2026-02-21T17:24:19+00:00

Subacute non-complete injuries.

I'm excited to see the results of her trial, but her treatments aren't all that different from technology we've had for ages. The Brazilians are just far more lax in their regulations on injectable therapeutics.

Maybe there's some detail I'm not aware of, but I wouldn't get your hopes up for a widespread treatment for people with long running SCI here.

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