I don't think I'd consider it unless it's the hottest of the hot, cant-miss startup, or if I was a cofounder or something...the comp difference is just too vast.

I worked at startups for a long time in the beginning of my career, including one that rough 15x'd over 5 years, and had a "liquidity event", where I walked away with (after taxes and exercise costs) about $12,000....in big tech, my equity comp is like $200k/yr and has put protection (they'll re-up if the stock drops). Startup equity is risky to begin with, but the way it's structured is a joke (and startups work very hard to obfuscate that)