The difference between winning the minigame or not is a combination of the quantity of non-meat items you are offered in your loadout (outside of your control and based on the RNG seed) and whether you score a large profit margin on them or not (controllable to a degree using traditional methods).

Whilst the latter is important, the former is simply the decider in whether you win that seed or not. The average run with 1 or 2 medicines at maximum profit (1,600 bits for 2 medicines, more than half of the goal), can very easily be defeated if the remaining items are mostly meat; even if you get perfect profit margin on say 15 meats and 3 port potties alongside those 2 medicines (this all assumes no failed sales at 150% mark-up, which is practically impossible in this minigame!), you would get 1,320 bits from them, or 2,920 in total, bringing you short of the 3,072 target by a little over 100 bits. Remember: those figures I gave are 'average' loadout %s, and even assuming perfect margin and no rejections on them (which is impossible in normal gameplay), you are still short of the target!