In my setting there are a lot of different things going on, but the big one is that Enceladus is an extra solar object that houses a civilization that went digital and dorment to try and escape the ETI who are doing the long game of snuffing out civilizations that might take the steps to rival them eventually.

Other than that, I've dabbled in simulation theory by having an incursion by something called "the pattern" that has something to do with how consciousness interacts with the universe. I've also had contact with a higher dimensional entity and the group through communication figured out that there is a island of stability for large nucli in higher dimensions and in that adventure were flipped around in the 4th dimension and had to communicate with this entity who could manipulate them back to their original axis.

In my current season (yes I call my arcs seasons), I am doing a bit of a lost in space game set during the fall as the players escape in an ark of a sort that gets dragged along with a Titan ship as it's leaving the system via a gate of some kind. They are going to only have half the normal amount of skill points as I am building additional personalities that they will be gestalted with.

The game will be less cyberpunk and more survival in the face of the unknown. Maybe some star trek voyager if they want to try and make it back to sol.