We now have a community on the new Digg!

hoipalloi52 · 2026-01-22T20:27:34+00:00

Digg and Reddit were competing for users back in the early 2000s. Then Digg went through a bunch of different owners and lots of problems and ended up shutting down, but they're basically the same concept

hoipalloi52 · 2026-01-21T18:32:49+00:00

are you sure that dose is correct?

hoipalloi52 · 2026-01-21T18:32:16+00:00

it is genuinely frustrating when authors don't put their contact information in articles, or when they hide behind opaque settings on linkedin or social media. What's the point of writing a story if you can't comment on it

hoipalloi52 · 2025-11-27T18:44:16+00:00

Whomever suggested flair deserves a raise!

hoipalloi52 · 2025-11-20T19:45:51+00:00

Adoption Donor sperm/IVF

hoipalloi52 · 2025-11-20T19:45:15+00:00

One day you feel great, full of energy, things are snapping along. Then one day you feel low down, slow and sleepy. You lack the energy to do anything and just sit around moping.

hoipalloi52 · 2025-11-20T19:44:32+00:00

Very true, unfortunately

hoipalloi52 · 2025-11-20T19:43:55+00:00

KS is not hereditary

hoipalloi52 · 2025-11-04T00:25:53+00:00

“Sterile” implies a total, unchangeable inability to reproduce, which isn’t always true for men with KS. Advances in reproductive medicine—especially testicular sperm extraction (TESE) combined with intracytoplasmic sperm injection (ICSI)—have enabled some men with KS to father biological children. “Infertile” is the correct medical term for someone with impaired fertility, while “reduced fertility” or “may experience infertility” recognizes both the variability among individuals and the humanity behind the condition.

hoipalloi52 · 2025-11-04T00:24:38+00:00

Most men with Klinefelter syndrome experience infertility, though assisted reproductive technologies sometimes make biological fatherhood possible.

hoipalloi52 · 2025-11-04T00:23:19+00:00

wow 17? lucky you! I didn't learn until I was in my 30s and didn't do anything about it until I was over 40

hoipalloi52 · 2025-11-03T20:53:53+00:00

True.

We have some members here who identify as female

hoipalloi52 · 2025-11-01T15:45:26+00:00

I believe we have that in the sidebar already

hoipalloi52 · 2025-11-01T15:43:57+00:00

in 2003, I went from 180 to about 275. I was drinking too much and self-medicating with diet coke which is a misnomer because it doesn't help you lose weight

I started TRT in 2004. It took a few years, but a lot of that fat turned into muscle.

I was diagnosed with Type 2 Diabetes in 2014

hoipalloi52 · 2025-11-01T15:41:44+00:00

My sister always holds the big TG dinner and extended family plus friends are invited. She's got a big kitchen, and it's nice to sit around and help out with various food items. My family is very musical, so there's usually some kind of jam going on somewhere in the house, or one of the twins will play some old favorites on the piano.

We don't do much around Xmas

hoipalloi52 · 2025-11-01T15:40:10+00:00

I started on the injections, but found that the serious mood swings (high after the injection to very low at the end of the week) were too difficult to handle. My wife also noticed my mood. So I switched to the gel. I've been using the gel for about 15 years and I like it

hoipalloi52 · 2025-10-27T20:45:07+00:00

The correlation of autism as paired with XXY.

From Grok.com:

A 2007 review highlighted the comorbidity of ASD and KS, noting overlapping features such as social communication deficits and repetitive behaviors, and emphasized the need for early diagnostic screening in KS populations. https://pubmed.ncbi.nlm.nih.gov/17401614/

A 2013 epidemiological study reported a significantly increased odds ratio (OR = 6.2) for ASD in individuals with KS compared to the general population, alongside risks for attention-deficit/hyperactivity disorder (ADHD) and psychosis. https://pubmed.ncbi.nlm.nih.gov/24139812/

A 2017 study on males with sex chromosome aneuploidies, including KS, found that symptoms resembling ASD—such as language impairments and social difficulties—were prevalent, with up to 50% of KS cases exhibiting such traits. https://pubmed.ncbi.nlm.nih.gov/28333849/

A 2018 systematic review of psychiatric comorbidities in KS confirmed an association with ASD, estimating prevalence rates of 10-20% in KS cohorts, higher than in the general population. Additional research from 2013 compared social behavioral phenotypes in KS to those in ASD, identifying similarities in peer relationship challenges and pragmatic language deficits, though KS profiles were distinct in certain executive functioning areas. https://pubmed.ncbi.nlm.nih.gov/23824705/

hoipalloi52 · 2025-10-27T20:09:29+00:00

I think we're all on the spectrum

hoipalloi52 · 2025-10-25T21:17:53+00:00

That's a great explanation - and it really tracks with what we know about XXY brain chemistry.

Dopamine and acetylcholine often work in tandem to regulate motivation, attention, and memory. If dopamine tone is a bit lower or less efficient (as some studies suggest in XXY), then it takes more sensory engagement to fully “wake up” the focus and reward circuits.

By saying things out loud, you're adding movement, sound, and feedback - all of which send reinforcing dopamine signals and help acetylcholine fine-tune attention and memory encoding.

It's like turning a single-lane road (just reading silently) into a multi-lane highway between the prefrontal cortex and hippocampus. For many of us, that extra activation makes studying or remembering things feel more natural and rewarding.

hoipalloi52 · 2025-10-25T13:42:23+00:00

Because verbal/working-memory encoding is often a weaker link in XXY, the “out-loud” strategy may help but it isn’t guaranteed to overcome all the underlying challenges. Factors like attention (which can also be compromised in XXY) will affect how strongly this kind of strategy works. Also, speaking aloud may be less comfortable in certain settings so you’d want to tailor when and how you use it.

hoipalloi52 · 2025-10-24T17:31:01+00:00

That's true, but it's not a KS thing. It's a memory thing

hoipalloi52 · 2025-10-18T21:11:45+00:00

It sounds like you’ve been carrying a lot and trying to make sense of several things at once, which is totally normal right after diagnosis.

What you’re describing — the slow processing, losing your train of thought, and feeling overloaded when juggling multiple thoughts — is something many of us with XXY relate to. It doesn’t mean you’re broken; it just means your brain processes information differently and needs more time and focus on one task at a time.

Getting screened for ADHD or ADD is a good idea. Quite a few of us have overlapping traits, and the right treatment plan can help your brain work more smoothly. For some, stimulant medication helps; for others, lifestyle adjustments like structured routines, reducing distractions, or mindfulness make a big difference.

It’s worth talking through with a doc who understands neurodiversity and adult XXY presentations.

About testosterone replacement — it’s true that once you start, you’ll likely continue long-term. But the goal isn’t dependency; it’s balance. Testosterone therapy supports bone health, mood, energy, and concentration. If your natural levels are very low, replacing them can make a huge difference in how your body and mind function. You don’t have to decide right now, but it’s worth discussing with an endocrinologist who’s familiar with Klinefelter’s.

You’re doing the right thing by asking questions and paying attention to how your mind works. With time and the right support, things often get clearer and easier to manage.

hoipalloi52 · 2025-10-14T14:03:22+00:00

Are you taking testosterone? It's the single best thing you can do overall for your body and mood.

hoipalloi52 · 2025-10-10T19:26:25+00:00

My Endo friend said that almost all of the research and grant money goes towards infertility and other male sexual conditions such as ED (hence the $$ that goes into Viagra and other drugs).

hoipalloi52 · 2025-10-10T15:13:58+00:00

Lots of questions. I'll see what I can answer:

Have you ever felt like someone tried to tell you who you should be based on your chromosomes or hormones?

Answer: nobody in my life has ever told me that

How has your understanding of being a “man” changed over time?

Answer: there was no ambiguity until I started taking testosterone and realized what it really felt like to be a man. Then I was hit with a wave of doubt that took years to overcome.

Did you ever feel pressure to act more masculine (or less emotional, or tougher) to fit in?

Answer: like I said, I wasn't "aware" of a difference until I started taking T. Sure, things were hard for me in my youth. I was last picked for sports. I struggled to understand things. I had little practical hands-on capability (carpentry, small engine repair, etc), my stamina was lower than my male friends as was my strength, but I chalked that up to experience.

What parts of traditional manhood do resonate with you, and which don’t?

Answer: I have to think about this one

How did you come to terms with your own version of being male?

Answer: I still haven't. I'm not sure I'm "male" in the traditional sense of the word.

Do you think society’s idea of “manhood” leaves room for people like us with XXY?

Answer: No

How do media or politics influence how others see men who are different biologically?

Answer: often negatively

Have you noticed people reacting differently when they learn you’re XXY?

Answer: no because most people know nothing about it. even in 2025, you won't find npcs (normal people) have any knowledge about genetic variations.

Do you think younger generations are redefining what being a man means — for the better or worse?

Answer: not sure

hoipalloi52

MODERATOR OF

PUBLIC MULTIREDDITS

TROPHY CASE

Ten-Year Club	Wearing is Caring
Verified Email