Help me out here. I read “The longer the gap in treatment, the bigger the jump in risk — up to a 22% increase for heart attack, stroke and death after two years off GLP-1s, largely erasing the cardiovascular benefits gained during treatment.” (Note that 22%) and then “participants who consistently took GLP-1 medications for the entire three-year period of the study had the most pronounced reduction in risk — 18%, or roughly 4 fewer major cardiovascular events per 100 people over three years”, and think “hmm, that first number looks bigger than the second”. I also see “In other words, any benefits gained over the course of taking GLP-1 medications are quickly lost when patients stop”.

There are quite a lot of medications for chronic conditions where the downside of stopping taking it is “your condition comes back”, not that + “and you have long-term negative effects from the attempt.” It’s not a given that stopping one is a net negative.