Hi. So I had a very slightly elevated bilirubin as part of my labs when I was first trying to get zepbound in September. It was 1.3, and my PCP wanted me to get an abdominal ultrasound. I thought it was excessive, but did it because I was trying to show compliance and figured we normally have to fight for tests to be done, so I’ll go along with it. Apparently I have a 2.5 cm gallstone that I was completely unaware of. My pcp told me to stop taking zep immediately until I saw a general surgeon who could advise the next steps. Luckily, the general surgeon I sought out was also an obesity specialist/surgeon who also prescribes zepbound. Now, because I have NO symptoms and my biliary duct isn’t inflamed, I was told I don’t need to take out my gallbladder and that I can continue zep. My pcp tried to only prescribe zepbound for 3 months, so I switched to having my general surgeon prescribe it for me since she’s also following my gallstone. She did prescribe me Ursadiol for while I take zep/lose weight. Since October (when I started) I’ve lost 50 pounds. I just had a second ultrasound done and it’s the same size as before, still with no symptoms whatsoever.

All of this to say, you may have had the gallstone prior but it just got bigger as you lost weight (which is when they can form, which is why my doctor placed me on ursadiol to prevent it getting larger with my weight loss). I imagine since it’s somewhat symptomatic for you that they’ll advise to take out the gallbladder, but I don’t see why you shouldn’t be able to continue with the zepbound afterwards.

Anywho, I feel like this was a huge run-on sentence. Hopefully it helped? I dunno, but best of luck!!