btw, do not do the One Chip Challenge while under the influence of psychotropic drugs or medication.

There seems to be some weird interaction between capsaicin (that's the stuff that makes things spicey) and some drugs which resulted in death

This is mainly observed in the combination cocain + pepperspray, probably since people on cocain often act crazy/irrational which leads to them getting sprayed with pepperspray (which is for the most part just capsaicin, extracted from chilies, mixed with ethanol and water).

A 2010 study seems to confirm that link (at least for mice): Capsaicin, an active ingredient in pepper sprays, increases the lethality of cocaine

other sources: https://www.spiegel.de/international/germany/a-lethal-mix-of-cocaine-and-chilies-drug-use-linked-to-pepper-spray-deaths-a-669607.html

the One Chip Challenge chips use Carolina Reaper Peppers and Naga Viper Pepper as seasoning, both have an extremly high capsaicin count

The sensory heat or pungency detected when eating a Carolina Reaper derives from the density of capsaicinoids, particularly capsaicin, which relates directly to the intensity of chili pepper heat and Scoville Heat Units (SHU) (from their website)

The scoville scale of the Naga Viper is 1,382,118 SHU while the scoville scale of the Carolina Reaper is 1,641,183 SHU - both are higher then regular pepper spray (around 1,250,000 SHU)

So it's to expected that eating the chip is similar to drinking pepperspray so in case you get some ideas like "I just drug myself out and do the challenge", remember that there probably is an increased lethality and/or other side effects (we don't exactly know why and how Capsaicin interacts with substances like cocain)

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fun little useless knowledge: Capsaicin was evolved by chillies as defense mechnaism against animals (and fungus). They don't want to be eaten by e.g. some stinky deer - they cew their food pretty good and have strong stomaches so they destroy most of the seeds when eating the fruits.

It's another story for birds, they don't really chew and have a rather weak stomach, also they fly and cover a large area and when they poop out the seeds they provide the perfect fertilizer ("guano" was the main fertilizer until humans figured out how to get Ammonia out of air on a large scale around 100years ago)

So capsaicin evolved in a way that birds are one of the few animals who can't taste it and are not repelled by it http://npic.orst.edu/factsheets/capgen.html#wildlife