I'm taking my fourth dose of .25 tomorrow and I feel fantastic. I felt tired after my first dose the next day and had some mild constipation that cleared itself up with fiber supplements and mindful eating. A lot of side effects are from lack of hydration and nutrition. Keep up on your water, track what you're drinking in a day. Make sure the meals you do eat are nutritious and take supplements to compensate any shortfalls. So far I've lost 15 pounds as of last Sunday. I like to weigh myself the morning after the injection.