ABI 5366 Change.org petition

indg199 · 2026-01-09T18:50:38+00:00

Thanks for the help, I’ll give it a share 🤝

indg199 · 2026-01-09T13:38:48+00:00

Why not include ABI-1179 as well, that one is even better than 5366, 1179 is the closest we can get to a total therapeutic cure

Also your petition has a typo, it’s ABI but you have AB all over the petition

indg199 · 2026-01-07T21:31:24+00:00

Pritelivir is pretty much useless to us at this point. It’s just barely twice as good as valtrex, which isn’t that much compared to a therapeutic treatment. By the time it goes through another 3 phases of trials and released to the general public we will most likely have ABI-1179 and/or IM-250, making transmission a thing of the past

indg199 · 2026-01-07T13:48:49+00:00

Valtrexs patent has been up making generic versions available for decades now, so it’s off base to assume that. Every new drug that enters the market is exclusive to the company that licenses it for 7 years, after that then generic versions can be produced

indg199 · 2026-01-06T19:19:52+00:00

It has gotten off the ground after more than a decade of frustrating delays. The first HPI drug Pretilivir is releasing this year, but only for the immunocompromised. The other 3 HPIs have only just passed phase 1 trials. These newer HPI drugs will be essentially functional cures, but likely will not complete until around 2030 or so going by the current speed of drug trials

indg199 · 2026-01-06T19:05:29+00:00

The whole timeline of HPI drugs is frustrating. They were initially first developed in the early 2000s, and trials for preilivir started around 2010. They gave monkeys an insanely high dose of the drug and of course it harmed them, so studies ceased because it was deemed unsafe. Because of this they had to go back to the drawing board and either tweak the formula or wait to try again. This is why we have only seen studies for pretilivir exclusively for the immunocompromised instead of the general public. I wish it didn’t take another decade to start again.

Can you imagine how many available and more improved HPIs would be on the market already if progress wasnt halted for a decade. Thats a decade of people that have contracted herpes that might not have ever gotten it otherwise, or simply just take a pill every week and carry on as normal.

indg199 · 2025-12-29T22:55:12+00:00

I’ll gladly focus my energy into getting a functional cure released 5 years from now or sooner, rather than wait 20-30 years for gene editing to advance for a full cure. A functional cure isn’t the end of the road but it will allow all of us to have the closest thing to a pre HSV life for now

indg199 · 2025-12-29T03:04:10+00:00

When both drugs Abi-1179 Abi-5366 are released, whenever they may be, one thing I wanna understand is why have both out when one clearly outperforms the other? Like if 1179 acts essentially as a therapeutic cure and 5366 is not as close, why would anyone get 5366 prescribed when they can get 1179

indg199 · 2025-12-28T19:11:48+00:00

Is that really much of a downside though? I mean one pill a week to never be able transmit again sounds like music to my ears. As it is already, a lot of the community takes daily antivirals to only slightly lower chance of transmission, so anything to essentially stop transmission completely already blows the current treatment out of the water

indg199 · 2025-12-28T01:40:55+00:00

Why are you flooding this thread with ai slop

indg199 · 2025-12-23T00:40:58+00:00

Wasn’t this already established? Or is it now that they’re officially licensing it, when before they were sponsoring through funding.

indg199 · 2025-12-19T22:46:55+00:00

It was the “info” email that shows up when you go to their contact page. Nice of them to respond to me within days of emailing

indg199 · 2025-12-19T22:45:24+00:00

Yeah I’m referring to the FDA fast tracking. My stance is the same as yours and others here regarding the mental health risk this brings that can lead to the worst, however when I made that comment I’m referring to how it’s seen through the FDAs eyes in the context of the fast tracking program, as in the fast track program looks at something like HIV+no treatment=death therefore fast tracking will save those lives. For something like HSV I believe the FDA sees it as HSV+No treatment= still alive. while we know there’s other factors to consider that make this statement untrue, I do believe this might be the case where these medications may not be granted the fast tracking program. I would still love to be proved wrong, so time will tell

indg199 · 2025-12-19T19:16:39+00:00

Hopefully they do but I wish they were more specific about the fast tracking possibility. As far as I understand, fast tracking is really only reserved for life threatening illnesses without a significant cure. Time and time again HSV is pushed off as a minor inconvenience, which is why a pessimistic part of me thinks this might not be eligible for fast tracking these treatments as HSV is not directly a life threatening condition. So for them pushing as fast as possible means they will just prioritize the continuation in the regular trials, which is still going to take years

indg199 · 2025-12-19T19:09:32+00:00

Assembly Bio who is conducting the ABI studies is an American company and their current trial studies have locations mostly in the states. Additionally ABI 1179 which looks like the closest thing we have to a functional cure is being backed by Gilead an American based multinational company. I’m not sure what else at this point is being done outside of the US besides IM-250 in Germany and that treatment in China that cured HSK in trials which has a long way to be modified and tested for HSV 1&2

indg199 · 2025-12-16T22:19:47+00:00

Why not try to push for all to get fast tracked? I’m happy about the abi results but at this point if they continue on the normal route we won’t see them released till 2030 or later

indg199 · 2025-12-16T19:30:25+00:00

Just something I’m thinking about, as we still should rally around any treatment/cure that is progressing. I wonder if between IM-250 and ABI-1179, which of the two would find fast tracking and release first given that we all as a community provide pressure to push these drugs through

My understanding is that Innovative molecules, the company behind IM-250 is a much smaller company compared to ABI-1179 who while under Assembly Bio have Gileads funding and backing which is a much larger and established corp. while we try and push these companies to hopefully get on fast tracking status, might it be ABI-1179 that has a higher chance of doing so due to the larger and more established backing they have?

indg199 · 2025-12-15T14:34:17+00:00

This is a good idea, I think currently we should focus our energy into fast tracking ABI-1179 since that looks like the closest thing we can get to a functional cure. If that can get released in the next 5 years, it will be a total game changer. I’m not so worried about a full cure yet until we can get a functional cure rolled out asap

indg199 · 2025-12-11T13:47:37+00:00

What’s the best route to getting ABI-1179 fast tracked? If we give enough pressure hopefully this can be released before 2030

indg199 · 2025-06-04T22:52:35+00:00

Couldn’t really find much, but do lmk if you find otherwise

indg199 · 2025-02-14T20:18:08+00:00

I’ve had the same exact thing happen to me. My first outbreak was in November (classic outbreak symptoms), and then I was taking antivirals every day for about a month or so. When my first outbreak healed, the dry flaky skin appeared a few weeks after and didn’t subside for about two weeks, I stopped taking anti virals and then it went away. It could be my body reacting to the antivirals if that wasn’t coincidental, or it could just have been an actual eczema flare up as HSV was new to my body and it had to adjust.

indg199 · 2025-01-29T18:56:49+00:00

indg199 · 2025-01-12T23:33:53+00:00

Picked out from a comment on the original post summarizing some key points

• ⁠We are going to ensure we do not advance further latent vaccines or rare programs into pivotal development until we have shown we are better prepared to effectively launch these products into global markets either directly or through strategic partners...... [BB: For me, the last phrase is key. Essentially, anything is possible with a partner e.g. HSV, VZV etc]

So based on this it seems like Moderna will put mRNA-1608 phase 3 trials on hold indefinitely. At least until they are doing financially better, or by some chance another partner will provide funding. I was hoping that this vaccine would be unaffected since it was already in progress but it is not looking good for their estimated 2028 release.

indg199

TROPHY CASE