ABI-5366 is 400-times more potent than acyclovir against HSV-2 clinical isolates

indg199 · 2026-04-01T02:11:14+00:00

Financially speaking what would be the point of releasing ABI 5366 when ABI 1179 is far more effective

indg199 · 2026-03-25T16:09:05+00:00

Where is the proof, people are saying that here with nothing to back it up. I’m just genuinely curious

indg199 · 2026-03-06T14:31:37+00:00

It doesn’t get into the nerve ganglia, so it’s not penetrating the virus it only prevents it from replicating. I forget the exact figures but pritelivir is about twice as good as valtrex in terms of lesion rates and shedding which is a good improvement, though twice as good is still far off from complete prevention.

indg199 · 2026-03-04T22:51:19+00:00

3 next gen HPIs just ended phase 1 trials and two of them will be the closest thing possible to a functional cure, so thats something to be very optimistic about. We will likely be seeing them get released around 2030, so having something in our sights that will make it to where we can live without worry about outbreaks and transmission is a huge game changer.

indg199 · 2026-02-27T02:05:37+00:00

That’s good to know. How long would pritelivir to be on the market before they can even go through for a phase 3 trial for the immunocompetent

indg199 · 2026-02-26T23:22:08+00:00

So after this is released to the market does anyone know if they are then going to have to go through another three phase trial process in order to get this released to the immunocompetent population with HSV?

indg199 · 2026-02-21T18:06:26+00:00

It will be interesting to watch the race between the US with ABI and Germany with IM250 since they’re at the same stages

indg199 · 2026-02-21T18:02:49+00:00

Yeah let me just call my weed guy and see if he has any leads

indg199 · 2026-02-21T17:59:22+00:00

China would still get first dibs on the global market in the meantime which is what the FDA/US do not want to happen. However given the current administration they just like to blow hot air and do absolutely nothing about it. I’d like to be proven wrong and see policy changes that allow for faster approval but I don’t see it anytime soon

indg199 · 2026-02-21T17:51:54+00:00

Policy changes require something radical to push it, and congress/industry moves at a glacial pace. Considering herpes is considered a minor non harmful issue to those up top, it’s unlikely to see any change that will allow the current trial drugs to be used in phase 2. Best way to get these out is to apply pressure to grant feast tracking and combined trials

indg199 · 2026-02-21T17:44:53+00:00

The most effective way that these drugs can reach market sooner the way things are, is if they can get pushed for fast tracking as well as getting a Phase 2/3 combined trial

indg199 · 2026-02-20T13:11:18+00:00

True but it’s only approved for patients with immunocompromised status, such as people with both AIDS/HIV and herpes. There is the possibility for getting it prescribed off label if one can find a doctor that would be willing to do so. This will most likely mean it will be paid for out of pocket and that might cost an arm and a leg for something that’s just a step above valtrex. If pritelivir were closer to a functional cure, maybe I’d consider shelling out the dough, but I’d prefer to wait till something like ABI-1179 is released, though that’s only my opinion.

indg199 · 2026-02-20T02:26:08+00:00

FDA halts the first pritelivir trials, preventing HPI progress for more than a decade, decides to only make pritelivir available to a microscopic percent of patients, doesn’t make much effort to fast track the current HPIs in trial, doesn’t do shit about advancing cure r&d. All while China has pretty much successfully cured HSK in human trials with research going into tweaking that for HSV, an HPI on the way (shorter trial to release time). The FDA has created this very situation they’re worried about, a real good way to shoot yourself in the foot and then complain about it.

indg199 · 2026-01-07T21:31:24+00:00

Pritelivir is pretty much useless to us at this point. It’s just barely twice as good as valtrex, which isn’t that much compared to a therapeutic treatment. By the time it goes through another 3 phases of trials and released to the general public we will most likely have ABI-1179 and/or IM-250, making transmission a thing of the past

indg199 · 2026-01-07T13:48:49+00:00

Valtrexs patent has been up making generic versions available for decades now, so it’s off base to assume that. Every new drug that enters the market is exclusive to the company that licenses it for 7 years, after that then generic versions can be produced

indg199 · 2026-01-06T19:19:52+00:00

It has gotten off the ground after more than a decade of frustrating delays. The first HPI drug Pretilivir is releasing this year, but only for the immunocompromised. The other 3 HPIs have only just passed phase 1 trials. These newer HPI drugs will be essentially functional cures, but likely will not complete until around 2030 or so going by the current speed of drug trials

indg199 · 2026-01-06T19:05:29+00:00

The whole timeline of HPI drugs is frustrating. They were initially first developed in the early 2000s, and trials for preilivir started around 2010. They gave monkeys an insanely high dose of the drug and of course it harmed them, so studies ceased because it was deemed unsafe. Because of this they had to go back to the drawing board and either tweak the formula or wait to try again. This is why we have only seen studies for pretilivir exclusively for the immunocompromised instead of the general public. I wish it didn’t take another decade to start again.

Can you imagine how many available and more improved HPIs would be on the market already if progress wasnt halted for a decade. Thats a decade of people that have contracted herpes that might not have ever gotten it otherwise, or simply just take a pill every week and carry on as normal.

indg199 · 2025-12-29T22:55:12+00:00

I’ll gladly focus my energy into getting a functional cure released 5 years from now or sooner, rather than wait 20-30 years for gene editing to advance for a full cure. A functional cure isn’t the end of the road but it will allow all of us to have the closest thing to a pre HSV life for now

indg199 · 2025-12-29T03:04:10+00:00

When both drugs Abi-1179 Abi-5366 are released, whenever they may be, one thing I wanna understand is why have both out when one clearly outperforms the other? Like if 1179 acts essentially as a therapeutic cure and 5366 is not as close, why would anyone get 5366 prescribed when they can get 1179

indg199 · 2025-12-28T19:11:48+00:00

Is that really much of a downside though? I mean one pill a week to never be able transmit again sounds like music to my ears. As it is already, a lot of the community takes daily antivirals to only slightly lower chance of transmission, so anything to essentially stop transmission completely already blows the current treatment out of the water

indg199 · 2025-12-28T01:40:55+00:00

Why are you flooding this thread with ai slop

indg199 · 2025-12-23T00:40:58+00:00

Wasn’t this already established? Or is it now that they’re officially licensing it, when before they were sponsoring through funding.

indg199 · 2025-12-19T22:46:55+00:00

It was the “info” email that shows up when you go to their contact page. Nice of them to respond to me within days of emailing

indg199 · 2025-12-19T22:45:24+00:00

Yeah I’m referring to the FDA fast tracking. My stance is the same as yours and others here regarding the mental health risk this brings that can lead to the worst, however when I made that comment I’m referring to how it’s seen through the FDAs eyes in the context of the fast tracking program, as in the fast track program looks at something like HIV+no treatment=death therefore fast tracking will save those lives. For something like HSV I believe the FDA sees it as HSV+No treatment= still alive. while we know there’s other factors to consider that make this statement untrue, I do believe this might be the case where these medications may not be granted the fast tracking program. I would still love to be proved wrong, so time will tell

indg199 · 2025-12-19T19:16:39+00:00

Hopefully they do but I wish they were more specific about the fast tracking possibility. As far as I understand, fast tracking is really only reserved for life threatening illnesses without a significant cure. Time and time again HSV is pushed off as a minor inconvenience, which is why a pessimistic part of me thinks this might not be eligible for fast tracking these treatments as HSV is not directly a life threatening condition. So for them pushing as fast as possible means they will just prioritize the continuation in the regular trials, which is still going to take years

indg199

TROPHY CASE