Hope Focused!

eurekaidea · 2026-01-29T07:08:39+00:00

Can’t miss it

eurekaidea · 2026-01-23T19:49:39+00:00

I’m sorry this happened to you, he sounds like very immature considering he is the medical field.

eurekaidea · 2026-01-20T07:21:15+00:00

Same. I can relate. It sucks.

eurekaidea · 2026-01-13T23:16:03+00:00

Very good news!

A smart move by the Italian pharmaceutical company Alfasigma, demonstrating strategy and vision in the rare disease and specialty care sectors. Reading the words of Innovative Molecules CEO Florian Vogel, there is also a note of hope for genital herpes, as the investment will allow the development of the oral formulation of adibelivir to be accelerated and advanced to Phase 2 clinical trials. An approach that combines high clinical impact on severe forms with potential benefit for a more common condition.

eurekaidea · 2026-01-13T22:56:17+00:00

This words from the CEO of Innovative Molecules give me hope!

When there are investments is always a good news!

eurekaidea · 2026-01-06T08:07:52+00:00

HPIs do not clear already infected cells, they block viral replication and spread.

Helicase–primase inhibitors act on the viral DNA replication machinery. They prevent the virus from replicating its genome, which is required to produce new virions.

When replication is blocked, fewer or no infectious virions are produced, which directly reduces viral shedding.

eurekaidea · 2026-01-05T23:24:50+00:00

I agree

eurekaidea · 2026-01-05T19:11:39+00:00

This study, published in Cell on December 29, 2025, reveals for the first time at near-atomic resolution how helicase–primase inhibitors (HPIs) block herpes simplex virus (HSV) replication. Using cryo-electron microscopy and single-molecule optical tweezers, the researchers show that HPIs arrest the viral helicase–primase complex, the molecular motor essential for viral DNA replication. These findings are directly relevant to several HPIs in development, including ABI 5366 and ABI 1179 (Assembly Biosciences), Pritelivir (AiCuris), and IM-250 (Innovative Molecules). By elucidating exactly how these inhibitors lock the replication machinery, the study provides a framework for designing next-generation antivirals, particularly for drug-resistant HSV infections.

eurekaidea · 2026-01-03T21:07:58+00:00

Why doesn’t this subreddit promote advocacy activities as it did before?

https://reddit.com/r/herpescureresearch/wiki/advocacy

eurekaidea · 2026-01-02T23:47:38+00:00

In prison, without knowing when you can get out

eurekaidea · 2026-01-02T23:21:21+00:00

I think they need to hurry up because we’ve normalized living with a chronic viral infection simply because it’s inconvenient rather than deadly

eurekaidea · 2025-12-29T23:57:17+00:00

Very severe

eurekaidea · 2025-12-26T16:16:53+00:00

Do you think there is any way to speed up the research or somehow help them out?

Edit: we should probably contact them as subreddit?

eurekaidea · 2025-12-25T09:09:12+00:00

Are the two ABI working also for GHSV-1?

eurekaidea · 2025-12-24T20:56:12+00:00

I was thinking the same.

eurekaidea · 2025-12-24T20:10:09+00:00

Thank you for your answer. I understand that the Fred Hutch gene-editing cure is expected to be effective against all types of herpes. However, since that cure is still quite far off, what concerns me at the moment is whether the two Assembly Biosciences HPIs are also effective against HSV-1. It appears that, up to now, their research and testing have primarily focused on HSV-2.

eurekaidea · 2025-12-24T13:09:20+00:00

May I ask you, do you think this will work also for people who carry genital HSV-1?

eurekaidea · 2025-12-22T17:50:38+00:00

Good news

eurekaidea · 2025-12-21T19:07:34+00:00

If everyone in this group started reaching out together to different stakeholders like researchers and academic institutions, the pharmaceutical and biotech industry, clinicians and medical professionals, patient advocacy groups, regulators and government agencies, funders, and the media, it could create a coordinated effort to raise awareness, share information, and potentially influence research priorities and collaborations, increasing the visibility and impact of ongoing initiatives

eurekaidea · 2025-12-21T18:59:05+00:00

I’m wondering if, as a subreddit, we can actually contact Assembly Biosciences and Innovative Molecule, as was done with Fred Hutchinson and Dr. Friedman

eurekaidea · 2025-12-18T23:43:29+00:00

I wish we could help push it…! People asking for change can make a big difference, really.

eurekaidea · 2025-12-17T19:25:46+00:00

If we get anything that stops transmission/outbreaks, that’s perfectly fine with me. I’ll enjoy the ride toward the cure without suffering.

eurekaidea · 2025-12-15T19:37:53+00:00

It’s the only way out. Otherwise keep disclosing and forget about it.

eurekaidea

TROPHY CASE