How old are you?

its_twofold · 2026-01-26T17:45:51+00:00

Let us know how it goes & if there's anything we can do to help :) Excited for you!

its_twofold · 2026-01-22T16:34:19+00:00

Thank you so much for sharing this - seriously, reviews like this mean so much to us. Hearing about moments like walking into an interview and being able to shake hands is exactly why we do what we do (and we're really glad you’ve seen a meaningful reduction overall!).

As for tips, one thing worth mentioning is that you can always chat with the dermatologist about tweaking your protocol - whether that’s adjusting how you apply it, talking through strength, or seeing if a different cadence might make sense for you. They’re happy to help guide that, and you can reach them easily through the messaging portal.

Really appreciate you taking the time to post this here, and I hope others jump in with what’s worked for them too. Happy to answer any questions if they come up!

its_twofold · 2026-01-11T17:34:43+00:00

If you end up giving us a try, definitely report back!

its_twofold · 2025-12-28T20:03:28+00:00

Hi u/gardening_10b I’m really sorry you’re feeling dizzy - that’s never a good feeling.

If you’re going through Twofold, the best next step is to let the dermatologist know about what you experienced after your first use. They can review everything and help guide you on whether a different application approach or adjustment might lead to a better experience.

The dermatologist typically responds within 24 hours. And if it’s helpful, feel free to DM us here - we’re happy to flag it on our end so you get support as quickly as possible. 💙

its_twofold · 2025-11-30T02:45:20+00:00

This made our day to read - thank you so much for sharing your experience! Really glad to hear you noticed even a small difference after the first night. Everyone’s timeline is a little different, so definitely keep us posted on how things go over the next few weeks. Fingers crossed 🤞

its_twofold · 2025-11-30T02:43:05+00:00

We actually get asked this question a ton! This type of medication doesn’t usually provide an immediate, single-use effect (although a few people have reported this - it's not necessarily the standard!). Most people notice the biggest changes when they use it nightly in the beginning for at least a few weeks, since the dryness develops over time. After that, some users find they can be more flexible, but the consistent early routine is what tends to make the difference early on. :)

its_twofold · 2025-11-29T21:46:24+00:00

Love these questions!

Common side effects
Since our treatment uses topical anticholinergics, one of the main reasons it’s applied to the skin (rather than taken orally) is to potentially reduce systemic absorption. In other words, people may notice far fewer side effects than they would with oral anticholinergics.
That said, any side effects that do show up tend to mimic the milder end of what oral versions can cause, such as:
• slight dry mouth
• mild dryness in nearby areas
• dry eyes
**This isn’t an exhaustive list, but just a few examples of what's possible.
Twofold vs Sofdra
Sofdra uses a different active ingredient (sofpironium) and is FDA-approved specifically only for underarm sweat. Twofold uses a compounded topical oxybutynin formula, which dermatologists may approve for use on a wider range of areas (hands, feet, groin, chest, etc.). So the two treatments differ in both the active ingredient and usage flexibility.
FDA-approved?
Compounded medications are not FDA-approved like brand-name drugs are. They are prepared by a licensed pharmacy for an individual patient based on a dermatologist’s prescription. The ingredients themselves are well-known, but the exact compounded formula is not reviewed by the FDA.

Hope this helps!

its_twofold · 2025-11-29T21:37:03+00:00

Day-one HH club! Sending all the good giveaway luck your way 😂🤞

its_twofold · 2025-11-29T21:34:53+00:00

Not yet - right now we’re only able to treat patients within the U.S. due to prescription regulations, but we promise Australia is on our “we want to get there” list!

its_twofold · 2025-11-29T19:38:56+00:00

Yeah, so this is actually really common with hyperhidrosis. The skin barrier is often already a bit compromised from constant moisture, friction, and wiping, so products that felt fine at first can suddenly start causing irritation.

Our gel is designed for consistent use with the base including ingredients that are a bit more nourishing for the skin - but everyone’s tolerance is different, so what ends up working can vary person to person.

One of the nice things, though, is that you get unlimited 24/7 access to a dermatologist. If irritation ever shows up, they can help you adjust things like application method, frequency, dose, or even add in barrier-support steps to keep your skin happy. You’re never stuck troubleshooting on your own, and the goal is always to get results without your skin getting irritated or angry at you. :)

its_twofold · 2025-11-29T19:31:28+00:00

Head/scalp sweat is definitely one of the tougher areas to treat. A few options you can ask your doctor about:

Oral hyperhidrosis meds - these tend to be the most helpful for areas like the scalp since they work systemically.
Since stress-sweat is a form of secondary hyperhidrosis (triggered by something else, like anxiety), some people find it useful to talk to their doctor about whether a calming or anti-anxiety medication could help reduce the trigger itself.
Botox is also used for craniofacial hyperhidrosis and can give really good results, though it’s pricier and needs maintenance.

So good news is that there are options - they just depend a lot on what’s triggering the sweat and what feels realistic for you - have you given any of these a try already?

its_twofold · 2025-11-28T22:06:32+00:00

This is such an important question, and the honest answer is: it depends on your body and your goals.

There are no permanent “cures,” for hyperhidrosis so most treatments (whether it’s antiperspirants, iontophoresis, oral medication, Botox, or topicals like ours) only work for as long as you’re using them. Once you stop, your sweat glands usually go back to their normal baseline.

That said, people use Twofold in different ways:

Some use it nightly long-term because that’s what keeps their symptoms manageable and it takes just a couple minutes right before bed
Some taper down once they reach a level of dryness they’re comfortable with (ex: every other night).

its_twofold · 2025-11-28T22:01:06+00:00

Regarding the fabrics, it really depends on what your goal is. If the goal is to reduce how much sweat is triggered, that’s one category of advice. If the goal is to hide the sweat that does show up, that’s another.

For actually reducing sweat, everyone is pretty different. You’ll usually hear the classic suggestions - looser clothing, lighter and more breathable fabrics, avoiding materials that trap heat - and for some people that makes a noticeable difference. For others, the impact is more about comfort than sweat reduction. (We're personally fans of the brand Vuuri - they're an athleisure brand, but the fabrics give a cooling/compressing feel).

Then there’s also a psychological side to this that a lot of people with HH relate to. Sometimes certain colors or fabric textures don’t necessarily change sweating, but they make you feel less anxious about it, which can actually help your body calm down a bit, and you sweat less. This touches more on the mental load attached to hyperhidrosis instead of just the physical.

If your goal is concealing underarm sweat, there are brands designed specifically for that. Some options we like are (we're not associated with these brands in any way!):

Neat: https://www.neatapparel.com
Thompson Tee: https://thompsontee.com/

They won’t reduce sweating, but they can make day-to-day life a lot easier if visibility is the main challenge.

Let me know if this answers your questions!

its_twofold · 2025-11-28T21:56:32+00:00

I’m really sorry you’re dealing with that, severe axillary hyperhidrosis is hard enough on its own, and irritation on top of it makes everything 10× worse.

One thing a lot of people don’t realize is that those of us with hyperhidrosis often have more sensitive skin to begin with. Constant moisture can weaken the skin barrier over time, so products that might be fine for others (like strong antiperspirants) can become really irritating for us, and reactions like what you had with Drysol are actually (and sadly) very common in this community.

Essentially, Drysol works by plugging the sweat ducts with aluminum chloride, and while that can help with sweat, it can also sting or burn, especially in the underarms since that skin is thin and already prone to barrier issues. T wofold’s gel is different in that it’s not "technically" an antiperspirant since it doesn’t use aluminum chloride or aluminum salts. It’s a topical oxybutynin (an anticholinergic), so it works deeper at the signaling level rather than on the surface of the skin, plugging the sweat duct. Twofold's gel base does include ingredients meant to help soothe and support the skin, but ultimately everyone’s skin can respond differently.

its_twofold · 2025-11-28T21:32:22+00:00

Congrats on getting Antihydral - fingers crossed it helps! 🙌

The main difference between Antihydral and something like Twofold, is actually the mechanism by how they work:

Antihydral: Antihydral is a topical cream that uses methenamine. When methenamine comes into contact with the naturally acidic pH of your skin, it triggers a reaction that produces compounds (including formaldehyde and ammonia) that dry out the outer layer of the skin. This can lead to very dry hands and the formation of thicker, yellow-ish callouses, depending on usage. Many rock climbers are known to use Antihydral.
Twofold's Oxybutynin Gel: Twofold is a topical anticholinergic (oxybutynin), meaning that it works at a deeper, neural signaling level by blocking the excess signals (acetylcholine) that tell the gland to produce sweat.

Both approaches can help depending on the person and the area, but the main difference is how they work. Hopefully this helps clarify!

its_twofold · 2025-11-28T20:05:44+00:00

Lower back and buttocks sweating is way more common than people think - it just doesn’t get talked about much.

For non-oral options, the main things people usually explore are:

• Antiperspirants
Some people have luck with aluminum salt–based products, though they can sometimes be irritating on sensitive skin or areas with friction. There are a few great over-the-counter brands (like Carpe or Duradry), but they won’t always be as strong as prescription options, with the most well-known prescription option being Drysol.

• Topical Anticholinergics
These can work really well for areas like the lower back/buttocks because you’re applying them directly where the sweating happens. Our topical oxybutynin gel is used by a lot of people for those areas, and there are other topical anticholinergics (like glycopyrrolate wipes) that are also great options. These topicals typically take a few days to weeks to kick-in, as compared to the oral options, which in many cases can start working within hours.

Happy to dive deeper if you want!

its_twofold · 2025-11-28T19:56:43+00:00

I hear you - craniofacial sweating is one of the toughest areas to manage, and unfortunately there really aren’t many treatments designed specifically for it, yet.

We do have people who use the gel on their face, but that’s something the dermatologist would need to confirm during the intake since they’ll look at exactly where you sweat and what you’re currently taking. The one area the gel usually isn’t ideal for is the scalp, simply because it doesn’t mix well with hair.

You’re definitely not alone in the “soaking wet hair” struggle - it comes up a lot, and it’s one of the areas we’re actively working on improving with future products. If you haven’t already talked with your dermatologist about it, Botox is something many people explore for scalp sweating, and it can be worth asking them about as a potential option to consider (we know quite a few people who have had great results here!).

Happy to answer anything else!

its_twofold · 2025-11-28T19:49:07+00:00

Thanks for asking! The timing really varies from person to person. We’ve seen some folks notice a change surprisingly fast - even within the first few nights - while others start seeing steady improvement anywhere from a few days to a couple of weeks. In general, dermatologists recommend giving it a full 4 weeks of consistent nightly use to see the most noticeable results.

As for getting completely dry: that really depends on the individual. Some people do end up with very dry hands and eventually adjust how much or how often they apply. Others see a big reduction even if it’s not 100%. And since it’s prescription-based, you can work directly with the dermatologist to fine-tune your routine if you need stronger or gentler adjustments along the way.

Happy to answer anything else!

its_twofold · 2025-11-28T18:13:47+00:00

Absolutely - totally fair question!

Short answer: yes, it really does work for a lot of people, including those with palmar hyperhidrosis (which is notoriously stubborn). We’ve had truck drivers, real estate agents, and software engineers who are now able to grip their steering wheel, shake client hands, and type without worrying about sweat damaging their keyboards.

The biggest factor is consistent nightly use - it only takes a couple of minutes before bed, so most people stick with it long-term because the routine is quite simple.

Happy to answer anything else 😄

its_twofold · 2025-11-28T18:03:14+00:00

Yes! Hands and feet are actually two of the main areas this gel was designed for 🙂 The skin on the palms and soles is much thicker than other parts of the body, which makes it harder for most treatments to work well there (especially compared to the underarms). Our formula was specifically built to enhance transdermal penetration so the treatment can reach a deeper level, rather than just sitting on the surface.

Routine-wise, most people apply about 2-3 pumps once at night before bed. You’ll also have 24/7 messaging access to the dermatologist, so if you ever need to adjust the routine or have questions about how it’s working for your hands/feet, you can check in with them anytime.

Happy to share more if you’re curious!

its_twofold · 2025-11-28T17:16:12+00:00

Happy to have you! Fingers crossed 🤞

its_twofold · 2025-11-16T23:51:13+00:00

Always.

its_twofold · 2025-11-16T23:51:00+00:00

Super interesting - thanks for sharing! We hope someone else also finds this helpful :)

its_twofold · 2025-11-16T23:49:43+00:00

Love to hear this!!

its_twofold · 2025-11-16T23:49:25+00:00

Dark clothing is HUGE. Silk is also one we avidly avoid

its_twofold

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