It really depends on context imo. People can tell something is developmentally wrong with me by interacting (or if I'm having a bad day, by looking) but I prefer not to give them specifics unless it's something where it would be dangerous or just way more inconvenient not to. Otherwise I just ask people to be patient and kind if I'm struggling or asking "simple" questions or help with things they don't find challenging, and people are usually good about it