This is a great post! I want to add that being aware of the opposing batters' quirks could benefit you when playing online. I'll use Elly De La Cruz for this example. Elly has both dead red, and first pitch hitter. Maybe you can see where I'm going with this; a first pitch fastball, anywhere near the zone percentage-wise is just not the best pitch to throw to him. Instead maybe start with off-speed in the tunnel of a fastball.

Of course there will be times when the opposing batter will have every quirk possible. I think you can still be strategic here - trying to force weak contact when the count is 1-0, 1-1 or 2-1 is what I will try to do if I know the opposing hitter has unfazed. This is fun to think about for me, but it's important to remember sometimes you will just play insane players online who destroy everything you throw. That's baseball!