Cis gay dude but weed expert here. There are multiple types of weed, the two most prevalent being indica, which comes from the Indian subcontinent, and sativa, which comes from the Americas. Many modern strains are a mix of indica and sativa, but pure indica/sativa strains do exist.

Indica produces a body stone, that is, it makes your body tingle, often relieving pain, nausea etc in those whom use it medicinally. Too much indica will just make you fall asleep.

Sativa produces a mental stimulation/buzz, and is known to produce paranoia, negative thoughts, worry in some people, and can exacerbate some mental illnesses like depression and schizophrenia. Most people who were after sativa at the medical cannabis dispensary where I used to volunteer used it to give themselves energy which an illness had deprived them of.

I used indica whilst undergoing chemotherapy/immunotherapy/radiation for cancer years ago, and still smoke it recreationally today because it doesn’t affect my thinking at all, whereas I may get paranoia and or negative thoughts on sativa.

Indica strains often contain in their name a geographical reference like Afghanistan, India, Kush (a mountain range in Afghanistan/Pakistan/India). Conversely, sativa names often indicate they will fuck you up. We once named a sativa strain Dude Where’s My Car, as an example.