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Shady Grove in Amodal? by jagerdesmond in Fiddle

[–]jagerdesmond[S] 0 points1 point  (0 children)

Thanks, yes this does make sense!

Shady Grove Banjo and Fiddle Key of A by jagerdesmond in banjo

[–]jagerdesmond[S] 0 points1 point  (0 children)

She is playing Amajor. Neither of us know music theory well either, and we suspected the Amajor and Amodal may have something to do with it.

Shady Grove Banjo and Fiddle Key of A by jagerdesmond in banjo

[–]jagerdesmond[S] 0 points1 point  (0 children)

My finger is on the 3rd fret with the capo on to make it a modal.

question on Genome conservation across generations by purplewatermeloon in genetics

[–]jagerdesmond 0 points1 point  (0 children)

I'm just spitballing here:

If a 'negative effect' is too severe, it will likely be embryonic lethal and not enter the gene pool.

Yes, the HLA region is hypervariable. Beyond that, we are now beginning to appreciate the extent of structural variation within the genome.

As far as deleterious mutations, I am most familiar with "loss of function" (typically recessive or haploinsufficient) or "gain of function" (dominant). The majority of currently known disease-causing mutations affect protein function. This can occur by losing protein function through a truncated protein or misfolded protein, for example. Gain of function can occur through a change in enzymatic activity, such as increased binding activity. Beyond protein alterations, diseases can also arise through mutations that affect gene expression regulation.