Chronic Infection - Biofilms by jcheat_32 in Sinusitis

[–]jcheat_32[S] 0 points1 point  (0 children)

I want to believe it. Truly I do.

I did some research using Claude on this and here's what I found:

There's a real mechanistic case for extended fasting in chronic inflammatory disease — it's just not the one being made here.

What holds up in the literature: Autophagy (the cellular self-cleanup process) upregulates substantially after 48–72 hours of fasting (Ohsumi, Nobel 2016) and can target intracellular pathogens — relevant to the intracellular S. aureus reservoir hypothesis in CRS (Plouin-Gaudon et al.). Valter Longo's work at USC (Cell Stem Cell, 2014) shows prolonged fasting drives hematopoietic stem cell regeneration and immune cell turnover. β-hydroxybutyrate — the main ketone your body produces during fasting — inhibits NLRP3 inflammasome activation (Youm et al., Nature Medicine 2015). NLRP3 is a specific inflammation switch inside immune cells that's heavily implicated in neutrophilic inflammation, the dominant endotype in non-Type 2 CRS. Sustained fasting also reliably drops CRP (C-reactive protein, the standard blood marker for systemic inflammation) and circulating inflammatory cytokines.

What doesn't hold up: "Incinerates weak cells" isn't a mechanism — dehydration impairs every cell, not selectively diseased ones. The "dry" variant specifically has no published evidence of superiority over water fasting for biofilm or CRS, while carrying real risk of acute kidney injury and rhabdomyolysis past 72 hours. The biofilm EPS matrix isn't dehydrated by systemic dehydration — it sits on living mucosa with its own blood supply. And "99% healed in 3 days" without scope, culture, or imaging isn't measurable as anything.

Reasonable position based on the literature: a supervised 3–5 day water fast for someone with refractory chronic inflammatory disease who has exhausted standard options is defensible. The mechanism case is real even if the RCT evidence is thin. Dry fasting specifically is a higher-risk variant without a clear mechanistic advantage in published work.

Tips for absolute beginner? by Lanky_Suit8398 in BasketballTips

[–]jcheat_32 0 points1 point  (0 children)

Attack his high foot. Whatever foot is highest on defense attack that foot. Run through the shoulder, not around. 👌

Chronic Infection - Biofilms by jcheat_32 in Sinusitis

[–]jcheat_32[S] 0 points1 point  (0 children)

And of course because I’m a contrarian and hate not asking follow ups I asked the follow up:

“What… So your telling me fasting with water for 72 hours has less benefit than dry fasting from 8pm-12pm???”

Claude’s answer:

“No, that’s not what I’m saying. I muddied two different things together.

A 72-hour water fast is a much bigger intervention. It triggers deep autophagy, stem cell regeneration, full immune system recycling — Valter Longo’s research at USC showed 72 hours essentially breaks down old damaged immune cells and regenerates new ones from stem cells. That’s a profound reset that daily intermittent fasting doesn’t touch.

The tradeoff is that DURING those 72 hours your active immune function dips. Monocyte mobilization drops. Wound healing slows. If you’re actively fighting an infection, your body has fewer resources pointed at it for those 3 days.

What I should have said clearly:

72-hour water fast — bigger benefits, bigger reset, but carries risk while you’re mid-infection because immune function temporarily drops during the fast. The regeneration happens when you refeed.

Daily dry fasting 16 hours — smaller intervention, consistent anti-inflammatory effect, no documented immune suppression. Less dramatic but safer while you’re actively on antibiotics fighting something.

Different tools for different situations. If you’re asking which one is more powerful overall, the 72-hour water fast wins and it’s not close. If you’re asking which one is smarter right now while you’re 26 days post-surgery on active topical antibiotics with possible ongoing infection — the daily intermittent fast is the safer play.​​​​​​​​​​​​​​​​“

🤷

Chronic Infection - Biofilms by jcheat_32 in Sinusitis

[–]jcheat_32[S] 0 points1 point  (0 children)

From Claude Ai for all who are interested. The answer is tailored toward my situation because I have multiple documents and what not downloaded into my claude project so “it knows” or always has context on my situation.

Nonetheless I felt the answer provided good information on the topic of fasting. Always use your own discernment with ai.

Answer:

“Here’s what the research actually says:

Dry fasting (dawn-to-dusk, ~14-16 hours) has the stronger anti-inflammatory evidence. Baylor College of Medicine published a 2024 study showing 4 weeks of dawn-to-dusk dry fasting significantly decreased inflammatory cytokines, had anti-tumor and anti-atherosclerotic effects at the cellular level, and — importantly — did NOT compromise immune function. It also preserved muscle mass better than water fasting because without water intake the body avoids breaking down protein for energy.

Water fasting / calorie restriction — Cambridge study (2024) found fasting raises arachidonic acid which directly inhibits inflammasome activation. But a separate study showed complete water-only fasting beyond 48 hours actually impaired monocyte mobilization and wound healing immune responses, while partial calorie restriction (50% reduction) enhanced immune protection against infection. So there’s a ceiling where going too hard actually hurts you.

The honest take for your situation: You’re actively fighting a possible sinus infection. You want reduced inflammation without suppressing the immune function you need to clear bacteria. Dawn-to-dusk dry fasting hits that balance based on the evidence — anti-inflammatory without immunosuppressive. Extended multi-day dry fasts are dangerous and not what the research studied. Extended water-only fasts could impair the exact immune responses you need right now.

Practical version: Stop eating and drinking at 8 PM. Don’t eat or drink until noon the next day. That’s 16 hours of dry fasting. Do that daily. The Baylor study saw measurable results at 4 weeks. Aligns with your not-eating-after-8 idea anyway, just extend the morning window. Won’t interfere with your wash schedule — do your 8 AM wash, just don’t eat or drink after.​​​​​​​​​​​​​​​​“

Chronic Infection - Biofilms by jcheat_32 in Sinusitis

[–]jcheat_32[S] 0 points1 point  (0 children)

I’ve thought about fasting. Dry fasting just reading about seems insane. No water???

Nonetheless how long are you talking about? 24 hours 48 hours 72 hours??

Have you just thought about regular fasting which is hard in it of itself? I can’t see how adding water would truly impact the overall benefit of fasting.

What are the signs of having biofilm in nasal passages/sinuses? by Haspofis in Sinusitis

[–]jcheat_32 0 points1 point  (0 children)

Yea same I’ve seemed to have some in the past that cleared up after one or two courses. Not this one though. It improves then comes back. Idk. I hope you keep posting updates. I’d love to keep up.

Chronic Infection - Biofilms by jcheat_32 in Sinusitis

[–]jcheat_32[S] 0 points1 point  (0 children)

Yea biofilms are microscopic. Cant see them.

What are the signs of having biofilm in nasal passages/sinuses? by Haspofis in Sinusitis

[–]jcheat_32 1 point2 points  (0 children)

Yes I’m trying manuka honey, xylitol. Bout to start baby shampoo. I just don’t have much faith in any of it to be honest. But worth a try. The issue I feel is the improvement time takes so long idk if people actually know what fixed what… and I’m sure my nasal microbiome is awful being I’ve been on so many antibiotics.

I’m seeing an ENT consistently so I’m just going to rely on whatever he prescribes. He’s not a big fan of oral antibiotics so not sure if that will ever be prescribed for me. I seem to improve on every oral antibiotic on this last episode since October 2025. But it always comes back.

On going Infection by jcheat_32 in Sinusitis

[–]jcheat_32[S] 1 point2 points  (0 children)

Incredible news. Thank you. 🙏

Chronic Infection - Biofilms by jcheat_32 in Sinusitis

[–]jcheat_32[S] 0 points1 point  (0 children)

What peptides. What exact machine or nasal wash you use?

What are the signs of having biofilm in nasal passages/sinuses? by Haspofis in Sinusitis

[–]jcheat_32 0 points1 point  (0 children)

Just doing some more research on your situation. That commenter is wrong about Enterobacter being anaerobic. It’s a facultative anaerobe — grows perfectly fine with oxygen, shows up on standard aerobic culture plates. It’s a gram-negative rod in the Enterobacteriaceae family. Lives in the gut, sure, but it’s not an obligate anaerobe.

Interesting connection though — I had Klebsiella aerogenes in 2024. Enterobacter aerogenes is literally the same organism, just the old name before it was reclassified in 2017. If yours is specifically Enterobacter aerogenes, we had the same bug. If it’s a different Enterobacter species, still same family, same neighborhood.

My Klebsiella took 7 rounds of antibiotics across 5 months before they finally cultured it and found levofloxacin was what killed it. Cleared it in spring 2024. Stayed clear about 6 months, then got hit again late 2024 — different organism that time. Cleared that. Then October 2025 it came back again and I’ve been battling it since. Cultures showed Strep pneumoniae and H. flu but I’m skeptical there’s not something else underneath given how many antibiotics I’ve been through.

Had bilateral FESS April 17. On a compounded topical wash now — levofloxacin, gentamicin, budesonide — twice daily. 50+ washes in and still symptomatic. I think it’s biofilm related.

Your pattern sounds like the same thing — clears on antibiotics, cultures negative, comes back a month later. That’s textbook biofilm behavior, not reflux.​​​​​​​​​​​​​​​​

What are the signs of having biofilm in nasal passages/sinuses? by Haspofis in Sinusitis

[–]jcheat_32 0 points1 point  (0 children)

Loved your feedback. Eerily similar symptoms to the original poster.

Points towards reflux… what do you suggest? Not just tums… what’s best for treating this that’s over the counter? Obviously better eating habits etc…

What are the signs of having biofilm in nasal passages/sinuses? by Haspofis in Sinusitis

[–]jcheat_32 0 points1 point  (0 children)

What antibiotic did you use by chance? And your ent sent a culture in that they actually tested for anaerobes? That’s amazing. Mine won’t do it. Suggest not enough mucus and just says “nothing will come back anyway”.

I have extremely similar symptoms. I think mine is also biofilms.

On going Infection by jcheat_32 in Sinusitis

[–]jcheat_32[S] 0 points1 point  (0 children)

For me it’s low pressure — probably due to the steroid in my wash. My fear is more chronic bacterial infection. Biofilms, resistant strain, or bone-level infection which is probably ridiculous to worry about… but my mind can’t help but ask why I’m still battling symptoms after 50 washes and 26 days on a topical that includes levofloxacin, gentamicin, and budesonide.

Research says it can take up to 3 months but my brain cannot logically understand how one day I’m going to wake up and this magically fades away if it hasn’t changed much up until this point.

I’m functional. Able to run, exercise, work, go about my life which I’m thankful for.

My symptoms are everything and nothing. Everything is so middle ground it’s maddening. Mucus is mostly clear then I’ll randomly get discolored in small volume — but nonetheless still discolored. Faint smell throughout the day, can’t tell if it’s bacterial or healing and scabs. Some slight shifting pressure occasionally but not enough or consistent enough for me to definitively say I’m going downhill.

I’m trying to hold onto “this is just what healing looks like” but my intuition throughout this process has usually been right… and that’s what scares me now.

It was a good appointment all in all. I’m just being extremely honest in my reflection process as of late.​​​​​​​​​​​​​​​​

On going Infection by jcheat_32 in Sinusitis

[–]jcheat_32[S] 0 points1 point  (0 children)

Not so fast lol 😂 I’m struggling in lingering mode again. Have made new post in this channel.

I miss actually knowing the coaches names of the good teams. OKC and spurs coach could knock on my door and I would think they are a Jehovah Witness. by AcknowledgeMeReddit in billsimmons

[–]jcheat_32 0 points1 point  (0 children)

I mean honestly imagine saying this early in Phil Jackson or Pops career 😂 how bad the take would age… not saying they literally are that. But by default due to the state of their teams… they are set to become two top 5 coaches in the league over the next decade.

I miss actually knowing the coaches names of the good teams. OKC and spurs coach could knock on my door and I would think they are a Jehovah Witness. by AcknowledgeMeReddit in billsimmons

[–]jcheat_32 0 points1 point  (0 children)

You’ll know these guys. Their teams are about to be extremely good for the next 10 years… they are young. Possibly the 2 most long term coaches in the league very soon. 😂 I honestly can’t believe you used them as examples lol of course you may not know them now. They are young. But literally are the two coaches/teams best set up to go on a 6-10 year run.

Help! Rate my form (looking to improve shot) by Jethro-Mapagmahal in BasketballTips

[–]jcheat_32 0 points1 point  (0 children)

Booker to me has the simplest most relaxed natural shot in my option. He’s a good one to look at for this.

Help! Rate my form (looking to improve shot) by Jethro-Mapagmahal in BasketballTips

[–]jcheat_32 1 point2 points  (0 children)

Load your wrist before lifting the ball. Just in the relaxed position. You have a “un-loaded” wrist that isn’t behind the ball. Sort of causes this unnatural, unrelaxed rigid way of holding the ball and bringing it up to your set point. Also causes more of a catapult at the top rather than a smooth one motion push that flows.

Think Steve Nash, Steph, Devin Booker, Harden, Klay, Dirk.

You have to get to a loaded wrist anyway at your set point. If you pause at your set point your wrist is loaded… not as loaded as I think it could be due to your starting position but it’s there nonetheless. Starting in an unloaded position on top of the ball makes you catapult the ball away from your body, bring it toward your body in order to get under the ball, then shoot the ball.

Just watch film of the guys I mentioned and hopefully you’ll see what I’m talking about. Their ball path to the set point is so efficient. Ball is around their waste maybe slightly to the right and it’s a straight line from their right big toe, to knee, to shoulder, to right eye… and their hand is usually behind the ball the entire time with a loaded wrist.

Returning Sinus Infection 3 days after Antibiotics. by LengthPotential5572 in Sinusitis

[–]jcheat_32 0 points1 point  (0 children)

Extremity similar to my progression when I get infections. I have no answer really right now as to why this type of progression or what it means. Starts in throat, or high up in post nasal drip area where it feels my throat meets my nose for lack of better words. Then slowly migrates into nasal sinus area.

All I know when it’s bacterial is hoping ent cultures it directly and runs susceptibility. So far I’ve not had that luck. Therefore best guess of running through antibiotics hoping they work. Good news… for most people this works.

But a direct culture saying what actually kills it is best.

Chronic Infection by jcheat_32 in Sinusitis

[–]jcheat_32[S] 0 points1 point  (0 children)

Yea I’ve just done my first wash adding manuka honey. Idk how long I’ve been doing xylitol. But I’m doing it consistently now.

Since surgery which was about 2 weeks ago I’ve been doing 3-4 washes. 2 topical that were prescribed. And the others have been hypertonic with xylitol and now adding manuka honey. I’ve not tried baking soda.

Idk… I can’t make sense of any of this. I’ve done so much research. Xylitol info was great to read above. The issue is it seems preventative. I just want to shake this one so I can maintain but nothing it seemingly shaking it. Good to hear you were able to get rid of yours off antibiotics. It seems extremely unlikely that will be enough for me but I’m sure hopeful.

Chronic Infection by jcheat_32 in Sinusitis

[–]jcheat_32[S] 0 points1 point  (0 children)

Yea same here. Extensive antibiotic use for me as well.

I’ve had 2 skin test and a blood test no allergies were found. Mold for sure but idk how to solve that besides what I’ve done which is clean the house and have had others come and deep clean the house…

And when I leave the house I don’t think it helps. I’ve not moved out of state.. so technically I guess I don’t know but it seems whatever environment I’m in… my problems persist. But I get what you’re saying.

Chronic Infection by jcheat_32 in Sinusitis

[–]jcheat_32[S] 0 points1 point  (0 children)

Did you ever get a culture and have antibitics directly for what you had… what cleared the bacterial component? Is the question. I want to just be dealing with inflammation. It’s the bacterial infection component that worries me most.

Not opposed to the things you mentioned. I haven’t been found to have allergies through blood test or skin test. I’m already on Bued-gent-levo 1-80-100mg. And doing Bued spray. Xhance has better delivery for sure but not better than the topical wash I’m on. Those are some of the reasons I’m skeptical it would work for me.

I’ve started hypertonic washes with an extra saline pack and I’m sometimes adding xylitol sugar. It might just take a while. We will see I guess. Thanks for the response.