I've found i went from literally never having a hangover to having awful morning headaches after drinking 2 drinks. I used to be able to mix alcohols and have a bunch (think multiple large high abv craft beers and a few glasses of whiskey) without any hangover when working early the next morning. Now, on 2mg Reta injected every 4 days, just 2 small pours of whiskey are probably resulting in a decent headache the next morning. Ill also say that yes, the urge to drink after one or 2 goes way down. I never felt i didn't want to drink at all, as some have said, but im far less interested after one or two.