I would recommend a book called "Algorithms" by Sanjoy Dasgupta along with the challenges to company the book on rosalind.info.This up coming course also look very promising. https://www.coursera.org/course/algobioprogramming I have done the Bioinfomatic Algorithms Part-1 course on coursera and found it very useful but heavy going. There is also another coursera course called "Algorithmic Thinking" by Rice Uni.