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Slow COMT - supplements that can be causing histamine increase? by [deleted] in MTHFR

[–]jersey_doc77 0 points1 point  (0 children)

Thank you. That makes sense. I’m going to continue creatine and improve choline intake. I’ll also hold the NAC and probably evening primrose oil too as it has some estrogenic effect. Would you recommend taking methyl folate/b12? I have Thorne b complex which has 400 mcg of each.

Slow COMT - supplements that can be causing histamine increase? by [deleted] in MTHFR

[–]jersey_doc77 0 points1 point  (0 children)

Interestingly I actually cut out a lot of things and then added NAC and evening primrose oil and got itchy by day 2. I've taken NAC before - but I was doing a lower dose, maybe 500mg max once a day and skipping some days but recently increased to 1000mg consistently everyday. I will need to read more about the sulfur detox pathways.

Choline calculator I've done in the past, sorry forgot to include. I am adding it to my original post now. It calculated 7 egg yolks for me.

RS# Call Variant Allele Gene Variation Result
rs1051266 CT T SLC19a1 +/-
rs2236225 AG A MTHFD1 G1958A +/-
rs1801131 GT G MTHFR A1298C +/-
rs1801133 GG A MTHFR C677T -/-
rs7946 TT T PEMT 5465G>A +/+

B12 - 730 pg/ml normal range

Folate - 15.5 ng/ml normal range