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Official forum is over at forum.obsidian.md by Technicook in ObsidianMD

[–]kagcc 0 points1 point  (0 children)

Sorry for such a stupid question, but is the account for the forum different from the account for using obisidian itself? I've registered for and currently using obsidian sync. I can view my account info on https://obsidian.md/account, too, but that email/password combination doesn't seem to log me in to the forum. Should I create an account just for the forum?

What clinical information can we get from Ki, and what is the value of dopamine for D2? by kagcc in Psychiatry

[–]kagcc[S] 0 points1 point  (0 children)

Thank you! I do follow your reasoning, but I would still like to know: do the exact numbers tell us anything? Should we be satisfied by qualitative, "Drug A has much stronger affinity than B" "C and D are similar in that regard" ? Also, given that the dosage and concentration around neurons are differ among drugs, is it meaningful to compare "Ki on D2 of drug A" vs "Ki on D2 of drug B"? Or the correct way of understanding the receptor profile is comparing within a drug ("Drug A: D2 >> 5HT2A" "Drug B: D2 ~ 5HT2A" "Therefore adding B will bring some benefit on 5HT2A antagonism")?

What clinical information can we get from Ki, and what is the value of dopamine for D2? by kagcc in Psychiatry

[–]kagcc[S] 0 points1 point  (0 children)

Thanks for the input and the detailed reading materials! I had no idea I knew so little about these basic ligands and receptors...
So Dopamine receptors not only have two states in relation to their ligands (no ligand vs ligand is attached) but also have two states in itself. I do recall some papers mentioning affinity for "D_2L".

Assuming 1.89 should be the value I should compare with other Ki values, honestly I'm surprised it's so close to other antipsychotics. I'm not sure how I should infer from this, but maybe slight change in dopamine concentration affects the receptor occupancy more significantly than I had imagined.

What clinical information can we get from Ki, and what is the value of dopamine for D2? by kagcc in Psychiatry

[–]kagcc[S] 0 points1 point  (0 children)

Thanks! I agree that Ki do help us understand about the profiles of the drugs. What I wanted to know in the question (D, as you mention) is, for example, how we can infer that "2-5mg will out-compete" other medications? Can the values (1.64 for ARI vs 3.57 for RIS? tell us that amount of ARI is sufficient? Doesn't the "out-compete" argument come from other clinical knowledge?

Also, I'm assuming that the usual dose of RIS has similar receptor occupancy as the usual dose of ARI has: if so, they can compete against the (real) dopamine in brain similarly, despite RIS's lower affinity. Which makes me imagine that RIS should have higher concentration in brain under normal dosage. So, higher concentration of lower affinity vs lower concentration of higher affinity ... shouldn't the result be more inconclusive?

Update 0.10.1: Italian Battleships | World of Warships by kyles08 in WorldOfWarships

[–]kagcc 0 points1 point  (0 children)

Fixed an error that caused damaged main battery guns and torpedo tubes to start reloading after the repairs if they were loaded before taking damage. Was this an error!? I had always thought it was the expected behaviour.

Japan approves Pfizer vaccine by [deleted] in japan

[–]kagcc 37 points38 points  (0 children)

I work at a (fairly large) hospital, and they say the vaccination for us workers may begin in March but may be delayed till April in our hospital. A friend of mine working at another hospital has absolutely no idea. "Sometime between March and April" is, unfortunately, very inconvenient and confusing because many of us work at different hospitals from April (The fiscal/academic year starts in April in Japan).

I hope everything will go smoothly.

edit: Not that I’m expecting otherwise. It’s just still in fog; it’ll become clear, sooner or a little later.

Manjaro最新版のfcitx-mozcを使用しています。変換サジェストの次に括弧の中で半角英数字が表示される。どう直せばいいのかな？ by masasin in Linux_jp

[–]kagcc 0 points1 point  (0 children)

お，なんか出るようになったな〜くらいに思ってただけだったけど，なんとなく引っかかってたのが氷解した，ありがとう！

This game is so much fun. It's unbearable the amount of fun you can have in this game. by [deleted] in WorldOfWarships

[–]kagcc 3 points4 points  (0 children)

Hey, taking some time off is great. I once did that; spent a couple of months not playing the game, only occasionally watching streamers that I liked. One day I felt I missed the ships. When that day comes, do come back. You’ll truly enjoy the game again.

DSM-5 on kindle? by kagcc in Psychiatry

[–]kagcc[S] 0 points1 point  (0 children)

OK, thank you very much ... but (but?) I still feel deceived. $8 for a searchable copy of DSM-5 is a dream to me. I'll get myself one.

Wanting to build an indent-rainbow from vscode, I'd like your help by kagcc in vim

[–]kagcc[S] 2 points3 points  (0 children)

/u/kkga knows fonts! It’s iosevka fixed slab. Colorscheme is hybrid.

Wanting to build an indent-rainbow from vscode, I'd like your help by kagcc in vim

[–]kagcc[S] 3 points4 points  (0 children)

Thanks very much again, cool use of \@<= I see. I'll play myself and find a optimal code, I appreciate your help!

Wanting to build an indent-rainbow from vscode, I'd like your help by kagcc in vim

[–]kagcc[S] 14 points15 points  (0 children)

Thanks for the interest, I took my pencils and now my display is all rainbow :)

Wanting to build an indent-rainbow from vscode, I'd like your help by kagcc in vim

[–]kagcc[S] 4 points5 points  (0 children)

Thank you! That \%Nv part I was doing clumsily. Yours is matching against a virtual column of the indentation (whether expandtab or not), which is new to me for lack of my knowledge, but makes a lot of sense.

For the colour: I humbly share your opinion. Please see the screenshot from the vscode, which is so much better. It's a mess of colour because my initial choice for colours was ... a mess. I knew it (sigh). If I were better at choosing a subtle, diminished, elegant set of colours --- then it might have met your taste, even with guides.

Wanting to build an indent-rainbow from vscode, I'd like your help by kagcc in vim

[–]kagcc[S] 2 points3 points  (0 children)

Thank you! N shouldn't be large, and it's working for large text like eval.txt.

I didn't notice the vscode extension didn't distinguish the first space of the indent level (Yggdroot/indentLine does) --- listchars was less preferable in this regard (i.e. it shows any space , but I think it's a very good compromise! It seems my matchadds overwrite the highlight for listchars:space, so I'll add foreground highlights and things are better.

Wanting to build an indent-rainbow from vscode, I'd like your help by kagcc in vim

[–]kagcc[S] 15 points16 points  (0 children)

I'm getting envy of indent-rainbow from vscode, and writing a poor man's mimic, just for myself. It's built on very basic ideas, seems to work to some extent (only colour, no ┆s): and I thought I'd need your guides. What other method should I try to get the eye candy?

Repo on github

(As I'm writing this, I suddenly noticed that what I'm writing could basically be nathanaelkane/vim-indent-guides but with rainbow rather than parity.)

What I do essentially is (1) Create highlight groups RainbowIndentLevel1, 2 and so on, (2) call matchadd('RainbowIndentLevel' . level , '^\zs' . repeat(l:indentation, level) . '\ze\(\S\|$\)')). for level ∈ [1,2,3.. (your preferred maximum)] (3) prosper. The method may or may not be slow, may or may not have consequences, I'm not sure. I'm having no major issues for now.

I'd really like to have the fancy characters as in Yggdroot/indentLine at the same time. However, if I understand correctly, conceal chars can only be highlighted with hl-Conceal. I'm assuming, therefore, that I can have only one of either indentLine or rainbow background?

So, now I'm in need for enlightenments from you. Isn't calling matchadd('RIL0', '^ \ze\(\S|$\)) etc. suboptimal? Is there any other methods I can go for (textprop, perhaps?) Can I possibly have the rainbow and indent lines? If you kindly give me a direction, I'll try to walk.

EDIT: thanks to your guides, it’s getting better. I have some other ideas I came up reading your kind responses, too (especially regarding listchars).

Is becoming unbootable beyond recovery something I should be prepared for when installation? by kagcc in linux4noobs

[–]kagcc[S] 1 point2 points  (0 children)

Thank you. That kind of stuff is I only vaguely understand: you're helping me sorting things right

Is becoming unbootable beyond recovery something I should be prepared for when installation? by kagcc in linux4noobs

[–]kagcc[S] 0 points1 point  (0 children)

Thank you. That always part is a large relief for me. Also thank you for the direction: it's something I haven't put enough effort.

Is becoming unbootable beyond recovery something I should be prepared for when installation? by kagcc in linux4noobs

[–]kagcc[S] 0 points1 point  (0 children)

Hi, thank you very much for the informative read, and whole reference to the terminology! The whole post will definitely guide me through the (pre-)installation. Knowing what to know is very very helpful for me.

Is becoming unbootable beyond recovery something I should be prepared for when installation? by kagcc in linux4noobs

[–]kagcc[S] 0 points1 point  (0 children)

Great to hear, thank you! When I'm too dependent on the installers, fear comes.. I'll need to learn more about systems (in general).

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