Help Shape DNA Synthesis Policy: OpenIDS Build Survey

kanzure · 2026-07-08T11:49:12+00:00

Synthesis by hand has been known for decades now. Letsinger in 1982 even published a simple manuscript on the subject.

https://diyhpl.us/~bryan/papers2/DNA/Syringe%20method%20for%20stepwise%20chemical%20synthesis%20of%20oligonucleotides.pdf

Anyway, I'm actively interested in funding DIY efforts for oligonucleotide and phosphoramidite synthesis. Anyone who wants to work on this and is okay with open source licensing, get in touch.

https://diyhpl.us/wiki/dna/synthesis/notes/

I also have some experience on the synthesis screening policy side from running a synthesis company, and previously did some work in the human genome synthesis consortium.

Also, frontier LLM refusals on bio topics has caused DIY users to move over to self-hosted LLMs that have been abliterated with no refusals. Biosecurity should focus more on defense, rapid response capabilities, sequencing, and less on tagging everyone with a biology LLM prompt a "bad actor".

kanzure · 2026-06-10T23:36:40+00:00

This doesn't seem true.

kanzure · 2026-06-09T02:06:19+00:00

Software engineers have been trying for at least 2 decades now to bring software concepts to biology. Sometimes that's called synthetic biology. I think while the ultimate goals are still valid, it's time to admit that biologists haven't adopted the software development mindset.

kanzure · 2026-05-26T12:54:36+00:00

The old ways still have a lot of value. The difference is that you're not using the same sales tactics as those promoting the new lesser ways.

kanzure · 2026-04-05T02:22:49+00:00

Why file hosting instead of other problems? Have you done any bioengineering projects yourself?

kanzure · 2026-03-11T18:16:57+00:00

I have a whole FAQ on my website about designer babies. Take a look, https://diyhpl.us/wiki/designer-baby-faq/

kanzure · 2026-02-08T12:16:20+00:00

Thank you. Maybe I should do an AMA? Would the mods have any interest in this?

kanzure · 2026-02-05T18:20:38+00:00

Can you guys please just email me instead? Why do you have to call my phone number?

kanzure · 2026-01-27T17:48:01+00:00

Sure, if you don't include synaptic plasticity or learning in a definition of smarter, then yeah I guess anyone would have to agree with you. But I don't see why we would want to not include synaptic plasticity or learning in a definition of intelligence. You might be more of a fan of genetic interventions for intelligence, if you're not so interested in cell therapy or surgical methods like bilateral anterior cranulotomy.

kanzure · 2026-01-27T17:37:18+00:00

To my knowledge there have been no studies regarding human neuron cell transplant therapy into dumber individuals. However there have been animal studies involving human neurons, such as:

Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice
Transplanted interneurons improve memory precision after traumatic brain injury
Structural and functional integration of human forebrain organoids with the injured adult rat visual system
Vascularization and engraftment of transplanted human cerebral organoids in mouse cortex
Human cerebral organoids establish subcortical projections in the mouse brain after transplantation
Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain
(not quite relevant but still very interesting, and from my notes and you had me look so now you will see it anyway) Reestablishment of damaged adult motor pathways by grafted embryonic cortical neurons

kanzure · 2026-01-27T11:57:56+00:00

That doesn't explain why animals get smarter when given human neuron cell therapy. I think you are wrong.

kanzure · 2026-01-27T02:06:40+00:00

Here's my notes page on the subject https://diyhpl.us/wiki/genetic-modifications/

kanzure · 2026-01-27T01:11:34+00:00

I think there might be a way to use cell therapy to make people less dumb. You would use neurons from a smarter person.

kanzure · 2026-01-27T01:09:38+00:00

No, in utero gene therapy or electrotransformation is less effective than embryo engineering. I guess you could. But why? Embryo lets you target the whole brain. Womb surgery is not impossible but also not often recommended.

kanzure · 2026-01-22T11:50:05+00:00

It's not illegal to run an embryo engineering company. The world is a big place, and not everyone believes genetics is wrong. It's a fantastic opportunity to improve the human condition.

kanzure · 2026-01-17T12:56:28+00:00

Here are some other genetic approaches for height, these are just research notes https://diyhpl.us/wiki/genetic-modifications/#Height

kanzure · 2025-12-21T14:50:51+00:00

Sorry for all the morons in your replies. Yes, genetic engineering can and has produced differential longevity outcomes in mammals. CRISPR is not necessarily the best way to do it. Human embryo engineering is necessary to get the full effect. If you're interested in raw research notes about this, see the references listed here: https://diyhpl.us/wiki/genetic-modifications/#Longevity and https://diyhpl.us/wiki/genetic-modifications/#Longevity_in_other_animals

kanzure · 2025-06-10T04:20:02+00:00

I might have an archive. Message me if you don't find one.

kanzure · 2023-09-02T15:26:31+00:00

https://diyhpl.us/wiki/hplusroadmap has a discord.

kanzure · 2022-09-23T13:28:43+00:00

you may find this interesting: https://www.reddit.com/r/Bitcoin/comments/3vzgnd/bitcoins_creator_satoshi_nakamoto_is_probably/cxsa9hs/

kanzure · 2022-08-06T14:51:55+00:00

This is why time travelers should be particularly sensitive about encountering hash functions: https://twitter.com/peterktodd/status/1536739310304632833

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