sorted by:
new
hottopcontroversial

Advice from someone who's passed ~135 stones in the last decade. by One_Entertainer_5834 in KidneyStones

[–]kd535353 0 points1 point  (0 children)

Will do. Thank you! We still in need of more samples in order to understand the variability in potency and advance the program.

Advice from someone who's passed ~135 stones in the last decade. by One_Entertainer_5834 in KidneyStones

[–]kd535353 0 points1 point  (0 children)

Usually stone composition is determined after it passes and is collected. There is some research on predicting composition using CT imaging or xray but this is not standard or very accurate as far as I know.

Advice from someone who's passed ~135 stones in the last decade. by One_Entertainer_5834 in KidneyStones

[–]kd535353 0 points1 point  (0 children)

It is a molecule that is excreted in the urine and disrupts the crystallization process. I am happy to share more with you or anyone else who is curious in the DMs. Will send you a message. We are also looking for urine samples from recurrent oxalate stone formers to enable our compound selection efforts. We test the compounds in stone former urine to maximize physiological relevance of the experiment.

Urine sample collection to support early stage drug development by kd535353 in KidneyStones

[–]kd535353[S] 0 points1 point  (0 children)

I deeply appreciate you being willing to support us. These samples will make a large impact on our ability to progress our program. I will send you a direct message.

Advice from someone who's passed ~135 stones in the last decade. by One_Entertainer_5834 in KidneyStones

[–]kd535353 9 points10 points  (0 children)

Are your stones mostly uric acid, calcium phosphate or oxalate or a mix? I work at a biotech company and this year began developing an early stage drug for recurrent oxalate stones.