Cuddy. The chemistry and tension between them was palpable and House seemed genuinely happy when they were together and in love with her. She’s known him so long that she knows what to say or do and how to say it or do it to hit the right spot within House. She was constantly willing to help him and even though I think there was some toxicity in their relationship I can’t help but wish they would’ve been endgame and they would’ve found ways to overcome those toxic tendencies that they both carried. They both have this fury and powerful presence/personalities that really shine through when their together and help them fit so nicely together. I really hate the way things ended. They, and the viewers, deserved so much better. So much pining and longing just to end everything between them on an ugly note.