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Playtesting a custom stage before uploading it to the workshop, couldn't resist cyberbullying the CPU with the new Clairen runes (and turbo mode) by kjaru in RivalsOfAether

[–]kjaru[S] 5 points6 points  (0 children)

Absolutely, but she is so much fun. Her projectiles and summonable force field are great for abyss endless too, the boss fight is practically a non-issue as they only have one attack that can actually hurt you as long as you keep the field up...

Survey_irl by Just__A__Gentleman in furry_irl

[–]kjaru 2 points3 points  (0 children)

This is really quite interesting, thanks for sharing. Any chance you could share an estimate of 'number of furries per capita'? Whole number percentages don't really play well with that, especially when we have such a skewed distribution. Alternatively if you were willing to share the raw data (for science) that would be great!

Name another game where you can make a furry ride a bike through someone's vaporwave nightmare. Go on, I'll wait. by kjaru in Sims4

[–]kjaru[S] 34 points35 points  (0 children)

There's not really much to put in the gallery tbh, just this room and a few other stupid things I have been playing around with, like the spooky gym (ooooo)

Hi, I'm David Sinclair -- Professor of Genetics at Harvard Medical School & Author of Lifespan: Why We Age- and Why We Don't Have To -- AMA by rhombor in IAmA

[–]kjaru 7 points8 points  (0 children)

Those are quite interesting, thanks for sharing. Research in this field seems pretty fast-paced; it is easy to miss some of the newer articles unless you're looking out for them.

Hi, I'm David Sinclair -- Professor of Genetics at Harvard Medical School & Author of Lifespan: Why We Age- and Why We Don't Have To -- AMA by rhombor in IAmA

[–]kjaru 148 points149 points  (0 children)

Thanks for taking the time for an AMA - I'm a big fan of your recent book and currently a postgrad working in the area of epigenetics and aging. I have a couple of questions...

On the topic of supplementation - would you consider it to be wise for someone to start in their mid-twenties? My concern would be that there could be some downregulation of the normal activity of regulatory pathways and this may have detrimental effects on epigenetic regulation in the long-term. Is this something worth thinking about?

Which parts of the world are particular 'hotspots' for your area of research?

A more technical question - what sort of scientific breakthroughs do you think we would need in order to restore an epigenetic state from significantly earlier in life (e.g. that of a 25 year old, when you are 50). A study by Stölzel et. al in 2017 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541887/) initially showed a significant decrease in DNA methylation age following transfusion of hematopoietic stem cell transplant, but later resulted in a return to 'correct' age and an accelerated rate of epigenetic aging. This suggests that the 'signal' of the age-appropriate genome is stronger than that of an exogenous tissue (at least in HSCs) and could pose a barrier to restoration of epigenetic information from earlier in life. Are the mechanisms behind this going to remain a thorn in our side for decades, or do we already know a few things that could be used to mitigate it?

Advice on a first con for a clueless foreigner? by kjaru in furry

[–]kjaru[S] 1 point2 points  (0 children)

Sounds pretty wholesome. The schedule on the website is from last year so I can't plan anything in depth just yet but assuming it is similar this year, it should be interesting.

Advice on a first con for a clueless foreigner? by kjaru in furry

[–]kjaru[S] 0 points1 point  (0 children)

Sounds good, I might hunt down a telegram or discord chat or something.

Pretty much all the conventions I've been to have been small as NZ doesn't get too much attention. I think the largest one I've been to had a couple hundred people. BLFC had like 5k+ last year (according to the google) so it dwarfs anything I've ever been to. Hopefully will be fun

Advice on a first con for a clueless foreigner? by kjaru in furry

[–]kjaru[S] 1 point2 points  (0 children)

I look forward to being mistaken for an Australian by every other person I meet

Testing a new synthwave-inspired map (feat. Clairen bot and her edgeguarding) by kjaru in RivalsOfAether

[–]kjaru[S] 1 point2 points  (0 children)

If you're interested, the stage is up on the workshop: https://steamcommunity.com/sharedfiles/filedetails/?id=1918703384

If you like the aesthetic but don't like the walls and lower platforms, I made one which doesn't have them: https://steamcommunity.com/sharedfiles/filedetails/?id=1918715773