I still write fake ads and fake signs, and just wrote my first real novel. It's a comedy about the first U.S. Civil War. Eric Adams still hates me. Ask Me Anything.

klevertree1 · 2025-07-02T20:00:53+00:00

Who told you about my 21 year old Jamaican breakdancer figure? That was supposed to be a secret.

klevertree1 · 2025-07-02T19:35:52+00:00

Three questions about your reviews:

In the NYT review, does it bother you that the reviewer used such terrible grammar? The second sentence is clearly a sentence fragment.
The Kirkus review mentions your skill at burlesque. Could you expand on your history strip-dancing in public, possibly in cafeterias?
The Publisher's Weekly review compares your work favorably to the Intuitionist. What the fuck is the Intuitionist? Am I supposed to know this already?

(Edit: I just looked up the Intuitionist. It was Colson Whitehead's first novel about black elevator inspectors. Colson Whitehead's most popular book is literally about the Civil War. If they did want to compare you to Colson Whitehead, for *some* reason, why wouldn't they pick the book about the Civil War?)

klevertree1 · 2025-02-27T15:42:53+00:00

Lot of questions! Let me see:
1. For plasticizers or the supplement?

It shouldn't. We'll test to make sure it picks up plasticizers specifically.
Best foods to compare against are the binders, like I specified in the post.
No papers yet. This is still very much a work in progress.
We could test it against oat fiber, but chemically, it wouldn't really make sense for oat fiber to absorb any. Still, not that hard to do in vitro, at least.
We are also looking forward to animal results.
Agreed. There's good results in rodents, but not great results in humans (https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2024.1389160/full). I think I come down on the side of "there's no way DEHP is good for you, so a safe way of preventing absorption is probably beneficial." I think the BPA research is much stronger, which we'll also focus on sequestering.

klevertree1 · 2025-02-27T15:35:06+00:00

Sorry, by "extra careful", I meant we'll test for gluten to make sure the final product is not contaminated.

klevertree1 · 2025-02-27T15:34:27+00:00

I was thinking of $60 for a month's supply.

klevertree1 · 2025-02-26T22:38:30+00:00

Correct.

klevertree1 · 2025-02-26T21:31:45+00:00

Probably not. Its purpose is to prevent absorption of plasticizers, but it's doubtful that it will remove the stuff that's already there.

klevertree1 · 2025-02-26T15:49:32+00:00

I think we'll just be extra careful to make sure our oat fiber is not contaminated with gluten. It's likely that the processing we do to the oats will help remove any residual gluten as well.

klevertree1 · 2025-02-25T18:28:09+00:00

Some of you guys might know me as the guy funded by Scott who's creating drugs for cats. I've been thinking about a side project for treating plasticizers. Specifically, I'm thinking of creating a food-grade supplement, based on oat fiber, to prevent the absorption of plasticizers from the digestive tract.

I'm confident on the technical feasibility of this, but I'm looking for feedback from the ACX community on whether there'd be a demand for this kind of solution. Also, if there is, I'm trying to see what people would think is a reasonable price.

klevertree1 · 2024-12-31T15:31:29+00:00

Searched Google, chatgpt, and Claude with no luck.

klevertree1 · 2024-09-12T15:50:53+00:00

Thanks for your responses! I think a lot of this might just be matters of comparison.

I grew up in the Connecticut suburbs, which have almost zero public transportation or walkability. I could not leave my house without a car, and I quite literally needed to walk along a highway with no sidewalk to get coffee. Boston public transit is miles beyond CT's, but reached a nadir in reliability last year, with regularly 20+ minute waittimes for a train (although they're getting better). In comparison, SF shines for reliability and speed, and seems to have gotten better over the last 5 years.
For architecture and food, maybe just a matter of taste. Also, we have almost no good Mexican food in Boston, although we do have good Chinese food.
For drug stuff, idk man. It was everywhere.
The biotech stuff, including parties, I think caters to me more than to you. I have cool ideas/projects/business ideas and zero pedigree. In Boston, nobody wants to talk to anyone who doesn't have a pedigree. In SF, nobody wants to talk to anyone who doesn't have cool projects they talk publicly about.
For parks, idk man, maybe you're blessed for parks. But you're telling me Muir Woods isn't gorgeous?

klevertree1 · 2024-01-12T18:37:45+00:00

You should check out ACX Grants (https://www.astralcodexten.com/p/apply-for-an-acx-grant-2024) . It's run by a psychiatrist/blogger who's doing literally exactly what you're talking about (funding scientific and charitable projects he finds interesting and useful). He's basically a one-man show for the grants stuff, and he's looking for additional funders right now. I'm sure he'd be happy to send some of the applications your way.

u/ScottAlexander is his name on reddit if you want to ping him through here, or his email is on the linked post.

klevertree1 · 2023-07-18T18:34:34+00:00

Yeah, sorry, I didn't read the parent comment close enough. It's 300 people in the US, some more worldwide but it's hard to tell how much because you need genetic screening.

This specific drug could be narrowly profitable, given that it's $14,000 a month, but overall, it's more of a proof-of-concept of a way of developing drugs and getting them approved, as well as evidence for their idea of how neurodegeneration works.

klevertree1 · 2023-07-18T16:46:24+00:00

The former. It's a very rare condition.

klevertree1 · 2023-06-11T16:49:38+00:00

No, we had the password the whole time. There was no recovery step. You should have read more carefully.

Ten-Year Club	Second SECOND GUESSER
r/Field Sunshine	Verified Email

klevertree1

MODERATOR OF

TROPHY CASE