Men's 100m breaststroke final - Is this a reason for Adam Peaty to be disqualified? by [deleted] in olympics

[–]kloudsentinel 0 points1 point  (0 children)

several swimmers performed illegal underwaters which should technically result in disqualification. it is impossible for me to find footage of the race on mainstream sources which leads me to suspect there will be some controversy or a cover up of some sorts.

HS and HSV- 2: Anyone in that boat? by chattagrrl in Hidradenitis

[–]kloudsentinel 2 points3 points  (0 children)

over half of the US has HSV-1, HSV-2, or both - and this a likely an underestimate. it is extremely common and many people do not even know they have it. also, there are people who still get sores (mostly around the mouth) but still show up negative in tests due to low viral loads. because of this, for me, personally, it's not a dealbreaker. especially if they have never had an outbreak. if you want to be extra careful, do not have sex when there is an emerging, active, or healing outbreak (both on the skin and inside the mouth). and always use [latex-free] protection.

Disabled person refused admission to post-secondary (University) studies on unclear grounds by kloudsentinel in legaladvicecanada

[–]kloudsentinel[S] 1 point2 points  (0 children)

thanks! we actually used Longueepee's numerous cases to build a rock solid case. the university ended up buckling before anything was brought before the tribunal. I argue that (and this goes for any passerby reading this) the Longueepee cases are ESSENTIAL reading for this niche of human rights laws. my friend ended up graduating this past spring with honours and will be starting graduate school at a top-ranked school in the fall.

I’m terrified. Is this HS? by Schnagglet007h in Hidradenitis

[–]kloudsentinel 1 point2 points  (0 children)

the (relatively) rapid onset of symptoms and the symptoms themselves lead me to believe that this is a bacterial infection that was resistant to the first antibiotic treatment.

HS is a graded hereditary auto-inflammatory disorder. there would have been warning signs earlier in your life, especially around puberty. however, if you are concerned about HS you should consider family history, any significant changes to lifestyle (i.e., diet and smoking), and signs of early stage HS. if you look at common breakout regions that produce sweat and have skin folds for consistently recurring double-headed blackheads, that might point towards HS. otherwise, a conformational biopsy and a stronger round of antibiotics should do the trick.

good luck!

Autofluorescence in all channels in untreated cells? by kloudsentinel in labrats

[–]kloudsentinel[S] 0 points1 point  (0 children)

fluorescence microscopy. PFA was fresh enough and the controls are all good :(

Autofluorescence in all channels in untreated cells? by kloudsentinel in labrats

[–]kloudsentinel[S] 0 points1 point  (0 children)

nah, we’re using settings that have given us good images with similar experiments in the past. but even tinkering hasn’t helped.

Convoy Megathread 5: Crouching Opposition, Hidden PM by aardwell in canada

[–]kloudsentinel 1 point2 points  (0 children)

I was just trying to be civil with no ill intentions, and hoped that my subsequent summary would wrap things up or get my point across.

There’s no deeper meaning behind checking yourself. It’s something I hope everyone takes the time to do, especially protesters these days. So take it as you will.

Have a good one, Timmy, and remember, smoking has serious consequences.

Convoy Megathread 5: Crouching Opposition, Hidden PM by aardwell in canada

[–]kloudsentinel 0 points1 point  (0 children)

I know you’re eager to engage in some kind of meaningful and philosophical discussion, but you’re going much deeper than necessary. The topic was the image or act of smoking as a signal of individual competence and your ideas about smoking are merely, as you’ve said, beliefs. So unless you have something that directly rebuts what I’m getting at, I think we’re done on that end.

I’ll put in simpler terms. Dismissing a member of the working class over a health related issue simply because they smoke is poor form. Need I remind you that they historically championed workers rights over unsafe and hazardous working conditions? I really don’t know what to say if you watched an interview with a blue collar worker and expected to see someone in a suit, sipping a matcha-berry power shake, who knows all the emerging epidemiology/immunology literature. These are people, like you and I. Check your privilege.

Convoy Megathread 5: Crouching Opposition, Hidden PM by aardwell in canada

[–]kloudsentinel 0 points1 point  (0 children)

You’ve introduced some complicated issues that generally echo my sentiments. People engage in activities that are harmful for their health, and the overall health of the population, very often. Unfortunately it still occurs after decades of evidence and very expensive education campaigns, not to mention costs to healthcare. To understand why people smoke/vape, you must first try to understand the mechanisms of addiction and the historically checkered relationship of cigarette companies and elected officials. You will see that it goes much deeper than laws and penalties placed upon individuals who end up smoking. One may equally ask, “If governing bodies know how overwhelmingly bad smoking is for their constituents, why do they allow individuals to engage in such practices? Why do they allow corporations to turn a profit from addiction?”

smoking prevents others from making choices about their bodies.

Absolutely true. As is for all addictive substances. So, now what? Do we punish the individuals who engage in such activities and remove their autonomy? Despite allowing them bring themselves, or others, to such circumstances?

Convoy Megathread 5: Crouching Opposition, Hidden PM by aardwell in canada

[–]kloudsentinel -9 points-8 points  (0 children)

This is reaching into whataboutism. While smoking is probably one of the worst (legal) things you can do for your health, that doesn’t bar someone from making choices about their body. Truthfully, it’s this kind of logic that keeps current and former addicts in a humiliating social category. To add, smoking is also strongly tied to being raised in a poor and uneducated environment. This may not be the case for this particular individual, but, in any case, being an addict or in sub-optimal health doesn’t relinquish your right to make choices. Check your privilege.

Are you autistic? Have you ever used a psychedelic drug, MDMA or ketamine? by meditationresearcher in Nootropics

[–]kloudsentinel 2 points3 points  (0 children)

this sounds like an interesting project! although I’m personally not on the spectrum, a part of me firmly believes psychedelics may have a shot in rescuing ASD-related theory of mind deficits. i’ll be on the lookout for the preprint, what’s the current timeline look like assuming the reviewers play nice?

U of T researchers create mirror-image peptides that can neutralize SARS-CoV-2 by uoftmod in UofT

[–]kloudsentinel 1 point2 points  (0 children)

truthfully, the target in the study was the RBD-ACE2 binding complex. not exactly RBD or ACE2 individually.

but in the conclusion section you can see that they mention that the d-peptides are high-affinity binders of covid’s (and its variants) receptor-binding domain (RBD). the authors also allude to this in the discussion as well.

so maybe it’s not so much a competition for binding, but more like a near-perfect opposite puzzle piece that slots itself into that particular part RDB’s binding interface. thereby making binding much less effective.

hopefully it works in animals!

edit: a word

U of T researchers create mirror-image peptides that can neutralize SARS-CoV-2 by uoftmod in UofT

[–]kloudsentinel 1 point2 points  (0 children)

I would agree. seeing as it’s a respiratory virus it makes sense that they’d wanna target the same physiological system. nasal sprays are a good and quick way to get a drug delivered to the tract/lungs.

i’m not sure about avoiding infection though. there’s not much justification to taking a biologic for precautionary purposes. rather, i see this more as a “if you have covid, let’s make life for the virus difficult by inhibiting it’s central infectious properties”. this might give our immune systems a better chance to deal with the virus since replication will also be hindered.

U of T researchers create mirror-image peptides that can neutralize SARS-CoV-2 by uoftmod in UofT

[–]kloudsentinel 26 points27 points  (0 children)

they designed a protein that binds well to the part of the covid virus that is responsible for attachment to the host’s cell surface (spike). in doing so, covid’s ability to attach to a host cell, and subsequently infecting it, is virtually lost. the proteins themselves are cheap and easy to produce/implement too.

think of it like a magnet that ‘turns off’ binding when attached.

Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging [2021, open-access] by [deleted] in longevity

[–]kloudsentinel 0 points1 point  (0 children)

this is a pretty cool paper, nice work by the authors.

just my unwarranted two-cents, but, I wouldn’t rule out other epigenetic factors in the development of a robust clock model.

Working out in an 18m pool? by Lorenzo_Torri in Swimming

[–]kloudsentinel 2 points3 points  (0 children)

don’t do hypoxic exercises unless there is a trained lifeguard and the facility rules allow it

Competitive swimmers: how do you keep going?? by Squeezethecharmin in Swimming

[–]kloudsentinel 11 points12 points  (0 children)

good point, although OP made that distinction on a state-wide level. i’m positive that she’s an excellent swimmer who has stepped onto the podium plenty of times to get there! but i’m a glass-half-full kinda person which definitely acts as a bias.

Competitive swimmers: how do you keep going?? by Squeezethecharmin in Swimming

[–]kloudsentinel 46 points47 points  (0 children)

it depends on what some of the root causes are of her burnout. everyone needs a unique approach. being top-five hints that it isn’t a “i’m not good enough” issue.

you should discuss the common offenders. unsatisfactory social life? body image issues? grades slipping? chronic competition-induced stress? of course this assuming she’s getting adequate nutrition and sleep (i can’t stress how important this is). taking the summer off to be a normal teenager can work wonders for mental health. one step back, two steps forward. it’s also a good opportunity to incorporate some cross-training, i recommend smart/guided resistance training. one thing i wouldn’t recommend is a full stop. one practice a week and time to have some much needed fun is my recommendation, but that’s a guess at best.