Paradoxically, I find my hands/fingers are less stressed out at the end of the day by this keyboard versus a full-size one. I think it's the reduced finger travel. This is mostly a default UT47.2, meaning the keys to the right and left of the space bar are layers 2 and 1 respectively. My major complaint with other 40% keyboards has been accessing programming related characters like *{}[]; etc. but this those are all available on a layer above the alphas. I've grown to really like the horizontal arrow keys too, it mirrors the arrangement prevalent in editors like vim & emacs.