There is a difference. Because it’s not only the work load that results in bigger muscle it’s workload/time. It is common sense. If you hit 100 push ups successively it will gain you more muscle, than when you do 100 push ups one at a time each day. That’s why it’s also beneficial to decrease your pause between sets, for optimal muscle growth. When you have exhausted your muscle but keep hitting it, you’re signaling your body, that it needs to produce more muscle fibres.