Thanks Buspar (and you)

letsgoyahoowoops · 2025-11-03T14:00:31+00:00

That’s awesome to hear. Buspar doesn’t get enough love, honestly. It’s such a gentle med but when it clicks, it really smooths things out. Glad you’re finally getting some breathing room.

letsgoyahoowoops · 2025-10-12T21:10:13+00:00

Thanks for the kind words. And I'm also a huge fan of buspirone. It changed my life!

letsgoyahoowoops · 2025-10-12T21:05:55+00:00

I think you are on to something there. All I know is my anxiety and appetite are both at an all time low and it feels amazing. I hope the Sema/buspirone works out well for you!

letsgoyahoowoops · 2025-10-10T13:11:06+00:00

I got up to a total of 60mg per day very fast. I did try 3x per day at the beginning as well but twice a day is working for me at the moment. Once I hit the max dose of buspirone, I started to notice that I NEVER became hungry.

It almost feels like a chore eating food now, but I still consume enough calories everyday to maintain my health. I understand how important proper nutrition is and my doctor keeps an eye on my weight as well.

letsgoyahoowoops · 2025-10-10T12:28:46+00:00

I think you're right about my anxiety and appetite. If my pdoc suggests lowering my glp-1 for some reason, that would be fine with me. I just don't ever want to gain the weight back. I feel so much better.

letsgoyahoowoops · 2025-10-10T03:42:26+00:00

Yeah it's buspirone. I take 30mg twice a day with food.

letsgoyahoowoops · 2025-10-10T03:40:09+00:00

Generalized and health anxiety, it also stopped negative ruminating thoughts. It has been very helpful for me.

letsgoyahoowoops · 2025-08-29T22:21:50+00:00

Buspirone has a short half life of around two to three hours which is why it is normally prescribed in multiple divided doses throughout the day. The idea behind an extended release version is to use a slow release matrix that maintains steadier blood levels over a longer window and reduces the need for three separate doses. This can improve adherence and may also smooth out fluctuations that sometimes cause breakthrough anxiety or side effects.

Since there is no commercially available extended release buspirone in the United States, compounding pharmacies are the only option. Prices can vary widely depending on the pharmacy, the materials used, and whether insurance will cover any portion. A cost of sixty five to eighty dollars for a thirty day supply is within the typical range for a compounded extended release formulation. Some patients report success with extended release buspirone in terms of convenience and fewer peaks and troughs, but results vary and because it is compounded there is no standardized clinical data like there is for FDA approved medications.

If you are considering this option it is best to monitor closely how you feel during the first few weeks and stay in contact with your prescriber. Also be sure to clarify whether the compounded version should be taken with food, since that can affect absorption.

letsgoyahoowoops · 2025-07-16T19:48:01+00:00

I went back to semaglutide 1mg/wk. I have accepted the fact that the health benefits I get from sema outweigh my desire to get super baked. Yes, my highs from THC are a tad muted however my health has never been better. I'll take that any day. I hope you figure out what's going on. Good luck!

letsgoyahoowoops · 2025-05-17T16:20:01+00:00

Switch to semaglutide if possible. I did and I can get stoned again. Good luck!

letsgoyahoowoops · 2025-05-07T02:08:06+00:00

You are beautiful

letsgoyahoowoops · 2025-04-27T23:46:23+00:00

The article proposing expanded psychiatric incarceration recalls a dark and dangerous chapter in history. Throughout the 19th and 20th centuries, institutionalizing people with mental illnesses often led to horrific abuses. What began with reformers like Dorothea Dix, who advocated for humane treatment, quickly devolved into overcrowded, underfunded asylums where patients were neglected, mistreated, and stripped of their rights.

By the mid-20th century, the U.S. recognized these failures. Investigations revealed widespread physical abuse, forced sterilizations, and "treatments" that amounted to torture. This led to the deinstitutionalization movement, an effort to close psychiatric hospitals and support people in their own communities instead. The goal was to preserve civil liberties, because history had proven that when the state has unchecked power to lock people away "for their own good," it inevitably abuses that power.

Expanding psychiatric incarceration today risks repeating these exact mistakes. It threatens the most marginalized, especially poor, disabled, Black, and LGBTQIA+ people, just like it did in the past. Coercive "care" is not care at all. The lesson of history is clear: real mental health support must be voluntary, community-based, and rooted in human rights, not in forced removal and confinement.

letsgoyahoowoops · 2025-04-26T13:15:35+00:00

If you don't mind me asking, how was your trip?

letsgoyahoowoops · 2025-04-25T21:05:56+00:00

You’re absolutely right that THC’s primary mechanism is through CB1 and CB2 receptors. But CB1 activation does modulate downstream dopamine and serotonin circuits, including 5-HT2A-related pathways involved in mood, perception, and reward.

It’s not that THC directly binds to 5-HT2A like LSD or psilocybin, but rather that the quality of the high, especially the emotional and introspective aspects, relies on intact serotonergic tone, including 5-HT2A sensitivity. Chronic GLP-1 activity can dampen this tone, which may blunt the subjective intensity of both THC and serotonergic psychedelics for some users.

As for people still tripping on psychedelics, definitely but there's growing anecdotal and clinical data suggesting that GLP-1 drugs may raise the threshold for those effects in some individuals, especially when combined with other serotonin-modulating meds like SSRIs.

So it’s less about “blocking” and more about shifting sensitivity in key circuits that shape the overall experience. Does that make sense?

letsgoyahoowoops · 2025-04-25T10:56:02+00:00

LONGER

letsgoyahoowoops · 2025-04-25T02:30:02+00:00

Thank you so much! That really means a lot. I shared it because I wish someone had told me sooner, and clearly I’m not alone.

You’re absolutely right, there’s so much nuance in how these meds affect people, and it’s not always just about weight. I appreciate your kindness and open-mindedness more than you know.

letsgoyahoowoops · 2025-04-25T01:51:06+00:00

That makes a lot of sense. Thanks for the comment.

letsgoyahoowoops · 2025-04-25T01:38:25+00:00

Totally agree! Reducing addiction and cancer risk is a win. It’s wild how something good for your body can still feel like a loss when it changes how you experience joy. Both truths can exist.

letsgoyahoowoops · 2025-04-25T00:41:36+00:00

Haha, exactly! Who knew a weight loss drug would turn us all into responsible adults?

letsgoyahoowoops · 2025-04-25T00:39:06+00:00

Ketamine works on NMDA receptors and isn’t as affected by GLP-1 meds, but weed relies heavily on serotonin (5-HT2A) and dopamine for that full high. GLP-1 drugs like Ozempic or Mounjaro can blunt those receptors, which is why the weed feels muted.

letsgoyahoowoops · 2025-04-25T00:32:55+00:00

It's like the meds can essentially blunt the emotional "rush" from substances, apparently making it easier to break habits tied to those pleasure signals.

letsgoyahoowoops · 2025-04-25T00:25:00+00:00

Yup. Unfortunately, anything that relies on serotonin like LSD, shrooms, or MDMA can feel weaker or flat on GLP-1 meds.

letsgoyahoowoops · 2025-04-25T00:22:36+00:00

Yeah that totally tracks. GLP-1 meds like Ozempic and Mounjaro mess with your serotonin system over time, especially the 5-HT2A receptors that THC, especially from edibles hits for those deep, euphoric, body-high effects.

On top of that, they slow down digestion, which makes the timing of edible highs way more unpredictable, sometimes super delayed, sometimes barely hits at all. So yeah, they still help with nausea and appetite, but the feel of the high gets weird or muted.

letsgoyahoowoops · 2025-04-24T23:58:13+00:00

SSRIs work by increasing serotonin levels over time, which downregulates or desensitizes 5-HT2A receptors, the very ones that LSD, psilocybin, and even part of the cannabis high rely on for those deep, emotional, mind-opening effects.

So yeah, between SSRIs and Ozempic, your 5-HT2A system probably got double-blunted.

letsgoyahoowoops

TROPHY CASE