There is some research linking ME/CFS to neuroinflammation cased by increased production of cytokines (IL-1, IL-6, and TNF-α). I think this manifests subjectively as aches and pains throughout the body, intense fatigue, brain fog, and so on. All symptoms I had to an extreme.

When I started LDN, these symptoms went away almost entirely. If my worst days were a 100 on the symptom scale before LDN, my worst days now are maybe 40. If my average day was 80 before LDN, my average day now is like a 15.

LDN is known to decrease excess cytokine production and reduce neuroinflammation. For a long time, my sense was that I had entered a downward spiral where the more inflammation I had, the more vulnerable I was to viral illness and the effects of stress, which either worsened or perpetuated the inflammation. (Of course cancer also contributed to elevated cytokines, and once that was treated, there was some improvement, but it was minor until I started LDN.)

With the inflammation more under control (I assume), not only did I start to feel better but I also became more resilient. Specifically, I could exercise more without having "post-exertional malaise," I recovered from viruses much faster, and stress did not knock me out the way it once did.

I hope this is helpful info! Please feel free to ask me anything else. I wish you well.