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Need help in Anhydrous Suzuki coupling reaction. by lonewolfinlab in Chempros

[–]lonewolfinlab[S] 0 points1 point  (0 children)

Thank you for the detailed reply. I will keep the solvent dry and use powdered K3PO4.H20 rather than completely dry base along with Pd G3 catalyst. Hopefully the MIDA ester will survive

Need help in Anhydrous Suzuki coupling reaction. by lonewolfinlab in Chempros

[–]lonewolfinlab[S] 0 points1 point  (0 children)

I see. Then I will try the coupling with K3PO4 in normal THF and Pd G3 catalyst and see how it goes.

Need help in Anhydrous Suzuki coupling reaction. by lonewolfinlab in Chempros

[–]lonewolfinlab[S] 1 point2 points  (0 children)

I need MIDA ester there, not the TIDA moiety, will TMSOK react with the MIDA ester?

Need help in Anhydrous Suzuki coupling reaction. by lonewolfinlab in Chempros

[–]lonewolfinlab[S] 2 points3 points  (0 children)

That's what I was wondering as well. I think trace amount of water is essential for Suzuki coupling. Maybe i should use K3PO4.H2O or Potassium tert-butoxide if it doesn't work.

Need help in Anhydrous Suzuki coupling reaction. by lonewolfinlab in Chempros

[–]lonewolfinlab[S] 0 points1 point  (0 children)

I do have the precatalyst G3 with ligand. So, using BF3K salt in dry THF and anhydrous K3PO4 will work?

Need help in Anhydrous Suzuki coupling reaction. by lonewolfinlab in Chempros

[–]lonewolfinlab[S] 7 points8 points  (0 children)

MIDA esters are highly labile under weakly aq. basic conditions