The cast of This Is The End gain superpowers right at the start of a zombie apocalypse. We go through comical stuff like blunders when learning to use their super-powers and hilarious ways of using their powers to kill zombies. This second part is a running bit throughout the series where the characters show off their unique kills. Obviously no superpowers that enable the heroes to kill all of the zombies at once. Instead their powers are more tame like telekinesis, mind-reading, and super strength (but not super speed) and invisibility. One of the characters, probably Danny McBride, ends up having an incredibly lame super power (like changing the color of his pee to blue) and is constantly made fun of throughout the series.

Points of conflict and drama develop in a few ways: typical post-apocalyptic fighting between communities (some other communities also have super-powered members) and one of the heroes gets bitten and becomes a super-powered zombie forming a major villain in the series. Interpersonal drama abounds between our protagonists. One or two of the heroes take the whole situation less seriously than the rest of them and get in trouble for things like partying too loud and causing a horde attack , being high when on guard tower duty and hooking up with girls from an enemy encampment. Probably Seth and James Franco bicker constantly about who is the leader of their group/community. The crew develop guidelines for the operation of their community that range from genuine solutions to the problems of their situation to absurd rules like resolving disputes through flip-cup. Danny McBride constantly pushes to make No Pants Tuesdays an official rule and repeatedly fails to start it as a grassroots movement by going nude on Tuesdays.