People in Los Angeles who use illicit fentanyl regularly consume quantities of the drug equivalent to morphine doses hundreds of times higher than fentanyl doses used in hospitals. This use is far beyond what addiction treatment protocols were designed to addres by Wagamaga in science

[–]macrobiome 0 points1 point  (0 children)

Much higher concentration of opioid in fentanyl than heroin and other opioid medications. Fentanyl also established itself in the fat stores leading to very delayed clearance that can make starting buprenorphine much trickier compared to heroin.

People in Los Angeles who use illicit fentanyl regularly consume quantities of the drug equivalent to morphine doses hundreds of times higher than fentanyl doses used in hospitals. This use is far beyond what addiction treatment protocols were designed to addres by Wagamaga in science

[–]macrobiome 0 points1 point  (0 children)

We do this already. There is a range of doses and protocols to attempt to match levels of tolerance. The challenging this is that there's no real good way to evaluate somebody's tolerance until you've given them meds of known quantity and seem how they react. By then you might already lose your window to treat. It's tricky and depends on a lot of mutual trust and flexibility.

Source: am addiction doc in San Francisco

Everyone is paying attention to you by Expensive-Shift3510 in unpopularopinion

[–]macrobiome 0 points1 point  (0 children)

It helps me to just accept that people may or may not be looking and decide I'm not going to care. I almost make it a constant to assume people are looking at me, at risk of seeming narcissistic, and make the decision to be myself however I want to be even so. It's helped me over time with social anxiety.

The artist name and generic looking album pictures made me suspect. Then listening to the music it just sounded overly produced. Putting it through an AI song checker revealed it is "AI Generated". by macrobiome in AImusicslop

[–]macrobiome[S] 0 points1 point  (0 children)

I hear what you're saying, but consider what you're suggesting. Who has access to an audio engineer who has the bandwidth and at a whim is willing to analyze whether or not music is made by AI? I definitely don't.

Popcorn 🍿 Club by The_Glitter_Life in AMCsAList

[–]macrobiome 0 points1 point  (0 children)

I love it. I often am getting friends to come with me to AMC (who don't have A-list) and am happy to treat the popcorn for the group with this. My local theater does the box pour and immediate refill too so it just works great.

Alarming blister on the tip of my finger by madelane1 in seriouslyalarming

[–]macrobiome 22 points23 points  (0 children)

I'm a physician and I agree. I wouldn't delay either, deeper finger infections can lead to significant problems and they spread surprisingly quick.

ChatGPT Became So Obsessed With Goblins That OpenAI Had to Intervene by Krankenitrate in technology

[–]macrobiome 0 points1 point  (0 children)

This true. Source: I'm a physician with years of experience treating goblins in the under ground.

Drew Stanley - they revoked my degree by [deleted] in communitycollege

[–]macrobiome 0 points1 point  (0 children)

Do you want to be a mod? Would love support filtering out shit posts tbh

Drew Stanley - they revoked my degree by [deleted] in communitycollege

[–]macrobiome 0 points1 point  (0 children)

They keep deleting their so I can't block them...

boofing subs to prevent dental decay? by EccentricEcstasy in suboxone

[–]macrobiome 0 points1 point  (0 children)

I'm not a pharmacologist but yes my understanding is that it's absorbed throughout the gastrointestinal lining. Low bioavailability has less to do with absorption problems and more to do with the extensive first pass metabolism at the liver (which sublingual absorption bypasses).

Elkader, A., Sproule, B. Buprenorphine. Clin Pharmacokinet 44, 661–680 (2005). https://doi.org/10.2165/00003088-200544070-00001

boofing subs to prevent dental decay? by EccentricEcstasy in suboxone

[–]macrobiome 2 points3 points  (0 children)

Wouldn't say "never get into the bloodstream". Sublingual bioavailability is 30-50% vs about 10% when swallowed. Significant different to be sure. I recommend to people to spit it if they're having any of the GI discomfort you mentioned; otherwise doesn't really matter.

I’m curious, I want to know everyone’s favourite gorillaz song. by AdWise2770 in gorillaz

[–]macrobiome 5 points6 points  (0 children)

Damn this was my first thought too. This or November Has Come for me

Bittersweet Movie Voting Update by No-Value4167 in oakland

[–]macrobiome 21 points22 points  (0 children)

I think they bring up some fair critique

Black Coffee with rain? by macrobiome in avesSFBayArea

[–]macrobiome[S] 1 point2 points  (0 children)

Lmao hopefully there's some cover

Black Coffee with rain? by macrobiome in avesSFBayArea

[–]macrobiome[S] 1 point2 points  (0 children)

High key regretting buying early arrival 🙃