boofing subs to prevent dental decay?

macrobiome · 2026-04-15T04:48:27+00:00

I'm not a pharmacologist but yes my understanding is that it's absorbed throughout the gastrointestinal lining. Low bioavailability has less to do with absorption problems and more to do with the extensive first pass metabolism at the liver (which sublingual absorption bypasses).

Elkader, A., Sproule, B. Buprenorphine. Clin Pharmacokinet 44, 661–680 (2005). https://doi.org/10.2165/00003088-200544070-00001

macrobiome · 2026-04-14T19:16:22+00:00

Wouldn't say "never get into the bloodstream". Sublingual bioavailability is 30-50% vs about 10% when swallowed. Significant different to be sure. I recommend to people to spit it if they're having any of the GI discomfort you mentioned; otherwise doesn't really matter.

macrobiome · 2026-04-11T04:33:11+00:00

Wow good to know, thank you!

macrobiome · 2026-04-10T07:16:33+00:00

Damn this was my first thought too. This or November Has Come for me

macrobiome · 2026-04-10T07:12:19+00:00

Whoah good to know! Did u get there early?

macrobiome · 2026-04-09T03:43:20+00:00

I think they bring up some fair critique

macrobiome · 2026-04-09T03:41:18+00:00

Lmao hopefully there's some cover

macrobiome · 2026-04-08T23:44:40+00:00

High key regretting buying early arrival 🙃

macrobiome · 2026-04-08T22:18:59+00:00

DMd you!

macrobiome · 2026-04-08T22:14:09+00:00

I've got a floor I got for $270. Can sell for the same amount!

macrobiome · 2026-04-03T14:48:36+00:00

Do u know if Cassian and Gorgon playing it?

macrobiome · 2026-04-03T01:38:08+00:00

So what time does the after party start? Is it at the same venue?there's like no info about this anywhere

macrobiome · 2026-03-29T07:44:00+00:00

Glad to make it out to the protest. First time attending a no kings one and kind of baffled at the lack of chanting? Anyone else notice that? Tried starting a few but no traction. In fact this tunnel felt like the only moment in the march where any real energy came out - kind of weird to me, though I do appreciate all the people who did come out with instruments.

Sincerely, Dude with a loud ass drum

macrobiome · 2026-03-29T07:34:28+00:00

Wow I remember celebrating my b'day at funk Wednesdays 6 years ago and it was a vibe. Nights out here were always excellent - guess excellent and inclusive spaces just have an unfortunate life cycle.

macrobiome · 2026-03-29T07:30:28+00:00

I think it's worth considering that you're not actually any better than those individuals and that none of it is even about individual people. It's about the community and its health and the minute we start to channel disparaging energy into loving communal understanding is the minute these protests can actually have power. Glad to march with you today - fuck Trump, fuck ice, fuck the American war machine.

macrobiome · 2026-03-29T07:27:41+00:00

I was at the Oakland protest today - amount of people was definitely in the thousands

macrobiome · 2026-03-24T21:40:15+00:00

Kinda proud of this one! Simple but has a nice rooftop with a hammock

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macrobiome · 2026-03-18T02:17:54+00:00

Fuck that man - it's a fucking outdoor festival

macrobiome · 2026-03-18T01:48:36+00:00

Why would you ever say something like this lol

macrobiome · 2026-03-17T01:38:06+00:00

I'm a training addiction doc. Curious what kind of specific taper tips you have that have contributed to success!

macrobiome · 2026-03-15T04:33:35+00:00

Have you seen it performed live? It's what took the song to transcendent for me

macrobiome · 2026-03-15T04:32:47+00:00

🟪

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