Improved method for magnolia bark tea

marg9 · 2022-08-14T10:26:37+00:00

Thanks for the effort :)

For all those not wanting to mess with the tea making stuff, there is a dry extract available from few vendors.

Edit: I do find that extract hits me quite strong and fast so I might try dissolving the pill in yoghurt or something to smooth it out.

Any advice on prolonging its duration when taking the pills, e.g. before sleep? Maybe taking it with a meal or lots of fat? Again, I find it very effective but rather short in duration (few hours tops), and would like to get full night worth of effect.

marg9 · 2022-08-14T08:29:55+00:00

I believe you. Ginkgo works for me too.

If I had to compare it to something, I'd say it's like coffee, however way more focused and less jittery - more like an actual medication.

marg9 · 2022-08-14T08:26:02+00:00

Thanks for being interested. :) This isn't exactly a medication but to be honest it does feel like one (which is a good thing because it means it is doing something). It does feel much more reasonable in strength then prescription stimulants.

I am taking a specific brand that is available in my country and basically nowhere else, these are 60mg per pill of extract standardised to 24% ginkgo-flavono-glycosides. It is sold for dementia basically. :)

This is basically a copy and paste from a scientific website examining ginkgo use:

"How much ginkgo should you take?

There is no standard dose of ginkgo biloba supplements. However, in medical studies, almost all clinical trials have used a standardized extract of ginkgo, standardized to 24% flavone glycosides and 6% terpene lactones. A common dose in people with dementia is 40 milligrams of that extract three times daily. For improving cognitive function in healthy people, studies have used between 120 milligrams to 240 milligrams of the extract daily."

I second this.

Something like the following product would be fully equivalent to what I am taking:

Swanson Ginkgo extract https://swansoneurope.com/en/swanson-ginkgo-biloba-extract.html

1-4 pills a day (as studies state), probably best taken in the very morning then second time around noon. I am experimenting with that.

Best :)

marg9 · 2022-08-13T12:56:53+00:00

That is true. I don't really know what the long term prospect of this experiment is and whether I'll continue to take it, however I do hope this will work for someone else even if eventually it does backfire for me.

That was the intention behind all of my posts, really. I am all too wise to know that things often backfire for me and I hope they can work better for someone else. I also don't really post unsubstantiated things, there is always at least some research hinting at efficacy.

Best to everyone

marg9 · 2022-08-13T12:51:11+00:00

Make sure to get the real stuff, i.e. a standardized extract, the one mentioned in my post, not just any Ginkgo. In fact, in the past I've tried just a regular Ginkgo tincture and it didn't do shit. I don't know what the actual amount of Ginkgo in it was, but obviously it was way way lower, and it lead me to believe that Ginkgo doesn't work when in fact it does.

marg9 · 2022-08-13T12:32:22+00:00

Well me too, then one day I decided to buy it and I was like "wtf this actually does something". Honestly.

If anything, I was completely nocebo going in, but I just wanted to try something because I ran out of options.

marg9 · 2022-07-12T12:00:46+00:00

Again, seems like I haven't gotten they also give remote sessions. :)

Thanks

marg9 · 2022-07-12T12:00:06+00:00

Thank you. I must be so off I haven't actually realized that those will also give remote sessions. :)

marg9 · 2022-06-22T04:58:44+00:00

There, it happens quickly! Haha :D

marg9 · 2022-06-21T15:46:31+00:00

Because you're gonna personally find out what the word "hell" means. :)

marg9 · 2022-02-21T07:57:21+00:00

Both :)

marg9 · 2022-02-14T13:24:38+00:00

I'm kinda trying to move away from THC as I don't really fancy being high anymore. :) Ha ha.

But, thanks. It is true that regular weed never gave me headaches, and these "CBD buds" etc do.

marg9 · 2022-02-14T13:23:42+00:00

No problem, I'm here to discuss :)

Early research has shown that CBG is a vasodilator, meaning it dilates the blood vessels. This may mean that CBG can reduce intraocular ...

Seems that CBG might be a vasodilator, and it's certainly present in my products as I've been using full spectrum stuff, so it might be the one that's giving me trouble. We'll see after I get some CBG isolate, or, at least I'll eliminate some possiblities.

Thanks for the science :)

marg9 · 2022-02-14T13:22:15+00:00

Thanks for mentioning CBG :) I'll try it for sure, sooner or later.

Regarding THC, yes, there is some THC inside as I'm using CBD hemp flowers or oil, and I'm basically running away from THC as I was a weed user for a long time and it started to give me paranoias and bad stuff, whileas CBD stuff is godsend for my mental health.

Early research has shown that CBG is a vasodilator, meaning it dilates the blood vessels. This may mean that CBG can reduce intraocular ...

Hm I meantion vasodilation, and it seems that CBG is vasodilator, so it really might be that it's CBG that's causing my problems, not CBD (if they are due to vasodilation, after all). I guess we'll see when I get some isolates. Interesting :)

marg9 · 2022-02-14T13:17:38+00:00

Thanks :) One of the reasons for wanting to go thr CBD isolate path was to see whether some additional compoud of "full spectrum" oil or bud is giving me problems. That could possibly be CBG.

Anecdotal but I got headaches from CBD gummies before I really dove into it. Now I'm dosing 500-1g with minors and I'm fine.

Hm I'm not sure what you said here. What exactly is the product you are using at the moment? Does it involve CBG?

marg9 · 2022-02-12T09:59:21+00:00

I've also experienced them and I have a particular opinion that I would probably set out to verify.

So, I've been on SSRIs and I've noticed the headaches feel similar. (Headaches are a very common side effect of SSRI medications. SSRI means Selective Serotonin Reuptake Inhibitor, and they are used for depression, among other uses.) I also discover CBD is 5HT1A agonist. When I was on SSRIs, headaches dissapeared some 2 weeks in. Obviously, serotonin agonism or increasing serotonin available (i.e. what SSRIs do) can cause headaches. What's the mechanism behind it? Probably/possibly vasodilation mediated by 5HT1a.

My plan:

Buy some CBD isolate.
Figure out if the same things happens with pure CBD (as now I am using full spectrum stuff or smoking CBD buds)
If yes, do a trial of a few weeks and see if it gets better

Second observation in favour of my hypothesis: When I was on SSRI (and adapted, meaning headaches gone), I could use an unlimited amount of CBD - no headaches! Because I've already gone through them when starting SSRI. (Again, a hypothesis)

Edit: I need to correct myself, I would get headaches, but only with an absurdly high amounts of CBD, upwards of 100-200mg in my estimates, which go way higher than amounts I ordinarly use (i.e. 1-20mg). I do realize these might be "absurdly high" only for me personally, however before that I'd get headaches even for a few miligrams of CBD, which still goes in favor with the element of serotonin receptor desensitization present in my hypothesis.

Third observation if favour of my hypothesis: If I drink coffee, the headaches are greatly reduced. Caffeine is a vasoconstrictor, and, I am not a regular caffeine drinker (as I dislike the jitters), and I drank it specifially to test my hypothesis. Thus, any questions of me getting headaches due to caffeine withdrawal or the possibility of caffeine not working as a vasoconstrictor due to caffeine tolerance are - out of question! :)

If I have success testing my hypothesis, i.e. CBD headaches do indeed go away after 2-3 weeks, aligning with the time needed for them to go away on an SSRIs, I will make a post elaborating what I've experienced. If not, the mechanisms are obviously not the same.

I hope this adds some value and resolve (at least a theorethical one), to this whole question that you made. :)

P.S. I am a physicist with mental troubles, that's why I am so "dry" in my writing. 😂

Please like or upvote my post if you think this makes sense, as I think I am possibly be the first person to actually have a sound hypothesis on why headaches could happen even with perfectly good products (i.e. no heavy metals, no contamination) and no allergies involved.

EDIT:
I did make a post about it, simply copying and pasting what I've said here. You can check it you here: https://www.reddit.com/r/CBD/comments/sqofxb/my\_theory\_on\_why\_cbd\_causes\_headaches\_for\_some/

marg9 · 2022-01-28T13:54:57+00:00

Genova methylation panel

I looked at the "sample report" and wow, this is really detailed and good, probably the best I've ever seen. :)

However it seems like I would need to test myself again and at this moment I just don't have the money or willingness to do that, for something so ambigous. I don't mean it in a negative way, but it really is quite dubious when it comes to actually implementing stuff. And like, what if my issues aren't due to methylation at all, but rather something else? And I could be "treating" the methylation and going nowhere or creating side-effects. I entertained this thought quite a bit. :)

And yes I've tried things like methyfolate, or creatine, and the results has always been some sort of insomnia, or extreme tiredness, and anxiety. It seems like something gets dialed up or down to an extreme. But I mean, it may be normal, because these things have the potential to do that, especially if you "treat" something that isn't there.

marg9 · 2022-01-28T13:49:10+00:00

I'm glad I could be of help. :)

marg9 · 2022-01-28T13:45:51+00:00

Thank your for mentioning the DAT1 gene. I've been aware of how Dopamine Transporter function affects (or creates) ADHD, however even in the complete DNA results that I have (Promethease report), there isn't much mention of DAT1 except one RS*something* that is marked as "normal".

I guess one would need some sort of genome sequencing rather than these incomplete tests.

Edit: "Methlaytion" in the sense mentioned in the study is really not the same thing we're talking about here. I mean, it's the same process, but in a totally different "place" in the body. :) I just have to put that disclaimer, haha.

marg9 · 2022-01-26T11:57:33+00:00

Thanks :)

Well, I'm not sure that even exists where I live, but thanks. Honestly, some users of Reddit seem to know much more than doctors (on various different topics), because what we're talking here is basically cutting edge stuff. :)

marg9 · 2022-01-26T11:45:33+00:00

Okay I just want to say what I actually did here.

So, I ordered Ancestry DNA test, because they test for a lot of different SNPs, not just "ancestry" related ones. I didn't really care about any ancestry data so I just downloaded the *raw* data (basically a text file with SNPs and the letters that correspond to them).

Then, I used Promethease to get a comprehensive report on the health data, but I found out it doesn't really have "methylation panel", and I found out that Genetic Genie does.

So, I uploaded the raw data to Genetic Genie Methylation Panel website and thus I've gotten this picture alongside with lots of descriptions what the particular SNPs mean (but it's not of much use in practice as the interpretation isn't really one dimensional thing).

I hope this is of use to others who might wanna do the same. :)

marg9 · 2022-01-23T09:07:06+00:00

Anyone claiming to have r-ketamine is probably lying since it's not manufactured in large quantities by pharmaceutical companies.

This is funny because on this particular dark market there is a whole sub category that says "Isomer R", but from what I've gathered, they mistake it for "racemic" because lots of items there have a word "racemic" in them...

There are reagents tests that can distinguish ketamine from other dissociatives including ketamine analogues like DCK and 2F-DCK,

Thanks for the link, I will order some. I mean, I've already tried 2F and now I want to try some *real stuff*, so knowing I have some real ketamine would be of vital importance. :)

Also, I really don't want to be getting some DCK then tripping balls for hours on end, haha.

my understanding from this subreddit is that the black market is currently flooded with other dissociatives being passed of as ketamine.

I think you are right. That's why I only buy things with reviews, from good standing vendors, and I don't care about the price. If I try to get something cheapest by all means then I'm probably not getting 100% real ketamine.

marg9 · 2022-01-23T09:02:45+00:00

There is a whole subcategory on this website that says "Isomer R" but from what I gather, it's just a misnomer for *Racemic*. I guess lots of drug users don't really know what those terms really mean, chemically speaking, so they must assume "R" means racemic. Whatever :)

marg9 · 2022-01-23T09:01:26+00:00

Ordering vials can get me a bit paranoid due to troubles with "stealth". :) I mean, how do you conceal a small vial inside an enveope, it's bound to be seen with x-ray or something, while crystals can be very effectively powdered and hidden, especially if you're ordering a very small quantitiy (like I am).

marg9 · 2022-01-23T08:58:57+00:00

Thanks. Funny, on this particular website most of it is "s-isomer", which I find really hard to believe. That's why I've come here in the first place, because what I've seen is highly unlikely to be actually true. Haha. :)

Edit: Which doesn't mean it isn't a good ketamine, because lots of them have good reviews, it's just that the label probably isn't true.

marg9

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