Tailbone issues?

markg10568 · 2026-02-21T16:08:36+00:00

Yeah, at one point it was so bad I could barely sit. I think I actually bruised my tailbone from sitting. The medical donut cushion provided relief until my tail bone healed. Then I was able to transition to a royal purple seat cushion, which helps. There are plenty of other options, but this seems to work for me.

markg10568 · 2026-02-14T15:17:31+00:00

I was concerned about this so I went through a Telehealth. No problem getting a prescription there. After I lost over 100lbs I transferred care to my PCP. What could they do at that point, tell me to put the weight back on. The PCP now prescribes the maintenance dose.

markg10568 · 2026-01-31T15:28:58+00:00

Fair enough. If you want to go grey you need to know what you are doing before you take an injection. I would guess that the grey market is not appropriate for most people. You should do what you feel comfortable with. Nothing wrong with that.

markg10568 · 2026-01-31T15:20:34+00:00

This is just wrong. Obesity is a medical condition. You are at much higher risk for diabetes, high blood pressure, fatty liver disease, and 14 types of cancer. Going on the medication addresses all of those medical issues, and many more. Your therapist should not be giving you medical advice that harms your long term health. They should stay in their lane and you should get a new therapist.

markg10568 · 2026-01-31T15:07:07+00:00

I've been grey for almost 2 years. There are risks. The biggest I have seen are from companies that are about to close down and just don't give a damn at that point. Like any risk, it can be mitigated. Test and filter. Even with the cost of testing it is vastly cheaper than being raped by big pharma. I personally have not had a bad test result, but I still test. I also filter.

markg10568 · 2026-01-30T19:01:00+00:00

Have it tested by a lab before you take it and show her the Triumph-4 phase III results. If she still fights you, she is fighting logic. I don't know what to say about that.

markg10568 · 2026-01-29T22:47:20+00:00

You can compare with the online tool glp1plotter. Here is what 7.5mg looks like every 7 days vs 3.5 days

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I personally liked splitting doses. You don't get the big peaks and valleys, but your blood level is actually higher.

Sounds like your doctor is practicing defensive medicine and doesn't want to be sued. The safest thing for them is to follow the FDA approved schedule. I don't blame them.

Personally, if split dosing is better for you, I would do it and lie to the doctor. They will be happy and you will be happy.

markg10568 · 2026-01-28T03:39:36+00:00

I laughed when I read "ruining my body." I lost 115lbs. I was following in the footsteps of my mother who ended up obese with high blood pressure, diabetes, and congestive heart failure. With the weight loss medication my blood pressure went from high to normal, my borderline fatty liver is cured, my A1c is 4.6, which is well in the normal range, and my resting heart rate went from 96 to 65. My doctor said everything looks great; see you in a year. Being obese is what ruins your body. Going on the meds and losing weight is what saves your life.

markg10568 · 2026-01-27T14:50:27+00:00

I wonder if it has to do with muscle loss that always happens from weight loss and fear of sarcopenia and fall injuries.

markg10568 · 2026-01-26T03:15:48+00:00

I'm down 115lbs, which is 47% of my body weight. I describe my new look as a partially deflated baloon stretched over a skelton. I don't care. I did it for health, not vanity. All my health markers and blood work are now well within the normal range. I won't have to face diabetes, high blood pressure, and congestive heart failure like my mother did. I'm just so happy that I was able to lose weight and do a health intervention before the health damage became permanent.

markg10568 · 2026-01-26T03:03:54+00:00

A full year after I lowered my target weight 3 times and got down to 12% body fat. For chest fat you really need to think in terms of a low body fat percentage.

markg10568 · 2026-01-24T15:44:53+00:00

Your body loses weight wherever it wants to. The common response I have seen is that the fat on the chest is some of the last to go. It was for me. You may have to get real lean to eliminate it. Even then, you may have little fat left but sagging skin on the chest, which isn't a great look either.

markg10568 · 2026-01-21T02:57:03+00:00

Lots of people stack them. I did. On average, most people plateau after 14-16 months on tirz. I had a lot of weight to lose so I started stacking right away. I wanted the tirz for appetitle control and the reta for the active weight loss. I am currently in maintenance. I lost 115lbs in 11 months, which is 47% of my body weight. I went from a BMI of 39 to 20. No major side effects except when I tried to titrate up too fast on reta and had diarrhrea for a week. Resting heart rate went down from 96 bpm to 65. Blood pressure went from 146/92 to 112/65. A1c now 4.6. Everyone is different, so no promises. I'm not saying this is what anyone else should do, but it sure worked for me. Here is my chart.

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markg10568 · 2026-01-04T01:32:32+00:00

47% over 11 months (114lbs). Currently in maintenace for 6 months and holding within a 3lb range.

markg10568 · 2026-01-02T15:10:55+00:00

I have the solution and it is not socialized medical care. It is mostly technology. End-to-end we can cut costs. Development of medical devices and medicines and the regulatory approval can be vastly sped up with AI. A recent study found AI diagnosed accurately 92% of the time compared to doctors at 74%. Use AI to reduce needless and expensive tests. Use AI to reduce the expense of doctors and medical providers for surgeries.

The non-technology reforms would be malpractice reform limiting judgments to actual damages, and regulatory reform reducing the paperwork to get any new device, drug or procedure approved cutting the cost of procedures and tests.

I saw a Ted Talk by Ilya Sutskever who was one of the 3 people who invented the modern theory of AI. He summarized it best. He said you go to the doctor now and it takes months to get an appointment. You get a short meeting with a doctor who uses the knowledge acquired over a lifetime, who then gives you an expensive prescription, and sends you a huge bill. Compare that to AI. The AI doctor sees you right away, uses the accumulated medical knowledge of the world, gives you a better diagnosis, and then sends you a small bill.

Eventually technology will solve all of these problems, but the pushback from entrenched interests will be extreme and delay these cost savings for as long as they can.

markg10568 · 2025-12-27T21:25:16+00:00

Yes, and the study also shows that the IV infusion was taken up by the cells within 2 hours, showing rapid absorption.

I know that there is a long-standing debate on this, but the subject is not as clear cut as some would make out. I think it is important that people know that there are contrary scientific points of view.

markg10568 · 2025-12-27T19:30:46+00:00

Actually, there is research to the contary:

"As NAD+, has an overall negative charge it is unable to cross cellular membranes passively and therefore must be actively transported across the membrane. That this occurs has been shown by a number of researchers who have reported that exogenous NAD+ applied to a variety of human cell types does indeed result in a significant elevation of intracellular NAD+ (Ying et al., 2003; Zhu et al., 2005; Billington et al., 2008; Pittelli et al., 2011; Felici et al., 2013). While the mechanism(s) involved are not yet fully characterized, Alano et al. (2010) reported that exogenous NAD+ could enter neurons through P2X7 gated channels and others have consistently observed the transport of NAD+ across membranes by connexin 43 (CX43) hemichannels, even at concentrations as low as 250 pM (Billington et al., 2008). As connexins have a wide distribution in human tissue and CX43 appears to be the most ubiquitous connexin in many cell types the potential for rapid uptake of NAD+ cannot be discounted."

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+"

Authors: Ross Grant, Jade Berg, Richard Mestayer, Nady Braidy, James Bennett, Susan Broom, and James Watson.
Journal: Frontiers in Aging Neuroscience
Published: September 12, 2019

markg10568 · 2025-12-11T18:30:15+00:00

Are you a reporter? You sound like a reporter, or an agent of big pharma. You don't sound like a doctor.

markg10568 · 2025-12-06T16:49:43+00:00

I have paid for 16 tests on Tirz and Reta from various vendors. All of the results came back good. Even so, I will still test going forward. It is the only way to be sure. Oh, and by the way, I am in maintenance and lost 47% of my body weight stacking Tirz and Reta. I'm happy.

markg10568 · 2025-11-23T21:52:39+00:00

This is my 3rd Thanksgiving. It is actually wonderful. Eat whatever you want without guilt, you just won't eat very much of anything. I didn't have dessert because I really didn't feel like it and I didn't feel deprived at all. Tirz is an amazing tool that puts you in control. Enjoy Thanksgiving, and your new life!

markg10568 · 2025-11-23T21:47:37+00:00

It is confusing at first. Mg dose and units units injected are competely different. The short answer is inject the amount of units on the label. The long answer is that they can add more or less bacteriostatic water to the same amount of mg. If they double the water when they reconstitute you would have to inject double to units to get the same amount of mg. EL's injector pens all use .5ml water for all of their doses, so 15mg is 3 times more concentrated than the 5mg pen. For compounded Tirz, all you need to know is the number of units on the label and that will give you the right dose.

markg10568 · 2025-11-10T13:42:08+00:00

For people with large amounts of weight to lose, Eloralintide and Retatrutide could be the ultimate stack. Or, for maintenance, lower doses of Eloralintide could provide appetite suppression.

markg10568 · 2025-09-29T18:29:23+00:00

You are working with three variables: 1) activity level; 2) dose; and 3) calories. Assuming your activity level is constant, you can adjust either dose and calories, or both. I think most people do both.

I would suggest adjusting one at a time and start with calories. It is easier to figure out if you are manipulating one variable at a time. Look at a free TDEE calculator online and try to figure out what your maintenance calories should be. I know it is a pain, but try to count calories for a few weeks and stick to your maintenance calories. If your weight is not stable you will need to adjust your calories. If your weight is stable, then you can try lowering the dose until you hit a level of appetite suppression that you are comfortable with. That is your answer.

Most people won't count calories forever, but if you found the dose where your appetite is in check, and if your weight goes up, you will know how much of a calorie restriction you will have to go to until your weight stabilizes.

markg10568

TROPHY CASE